159622-10-3

• 常用中文名：(1R,2S)-1-叔丁氧羰基氨基-2-乙烯基环丙烷甲酸
• 常用英文名：(1R,2S)-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylic acid
• CAS号：159622-10-3
• 分子式：C₁₁H₁₇NO₄
• 分子量：227.257
• 相关类别： 生物化工 氨基酸及其衍生物 其他氨基酸衍生物
• 发布时间：2018-10-11 13:57:19
• 更新时间：2026-07-01 19:33:46

名称

• 中文名: (1R,2S)-1-叔丁氧羰基氨基-2-乙烯基环丙烷甲酸
• 英文名: (1R,2S)-1-tert-Butoxycarbonylamino-2-vinylcyclopropanecarboxylic acid
• 中文别名: 丙肝药物中间体; (1R,2S)-1 - [ [(1,1-二甲基乙氧基)羰基]氨基] - 2-乙烯基-环丙烷甲酸; (1R,2S)-1-[(叔丁氧羰基)氨基]-2-乙烯基环丙烷甲酸*5; (1R,2S)-1-(叔丁氧基羰基氨基)-2-乙烯基环丙烷羧酸; 阿拉匹韦中间体5; (1R,2S)-1-(BOC-氨基)-2-乙烯基环丙烷甲酸; 阿那匹韦中间体V; (1R,2S)-1-叔丁氧羰基氨基-烯基环丙烷甲酸; 1-叔丁氧羰基氨基-2-乙烯基环丙烷甲酸; (1R,2S)-1-[(叔丁氧羰基)氨基]-2-乙烯基环丙烷甲酸; (1R,2S)-1-{[(叔-丁氧基)羰基]氨基}-2-乙烯基环丙烷-1-羧酸
• 英文别名: 2-vinylcyclopropanecboxylic acid; (1R,2S)-1-tert-Butoxycbonylamino-2-vinylcyclopropanecboxylicaci; (1R,2S)-1-((tert-butoxycbonyl)amino)-2-vinylcyclopropane-1-cboxylicacid; (1R,2S)-2-ethenyl-1-[(2-methylpropan-2-yl)oxycarbonylamino]cyclopropane-1-carboxylic acid; (1R,2S)-1-(tert-butoxycbonyl)-2-vinylcyclopropanecboxylic acid; (1R,2S)-1-(Boc-amino)-2-vinylcyclopropanecboxylic Acid; (1R,2S)-1-[(tert-butoxycarbonyl)amino]-2-ethenylcyclopropanecarboxylic acid; (1R,2S)-1-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-2-vinylcyclopropanecarboxylic acid; (1R,2S)-N-tert-Butoxycbonyl-1-amino-2-vinylcyclopropanecboxylic acid; (1R,2R)-1-((tert-butoxycbonyl)amino)-2-vinylcyclopropanecboxylic acid; (1R,2S)-1-[(tert-Butoxycbonyl)amino]-2-vinylcyclopropanecboxylic Acid; (1R,2S)-1-{[(tert-Butoxy)carbonyl]amino}-2-ethenylcyclopropane-1-cboxylic acid; (1R,2S)-1-[(tert-Butoxycbonyl)amino]-2-ethenylcyclopropanecboxylic acid; VINYL ACCA A.K.A (1R,2S) N-BOC-1-AMINO-2-VINYL CYC; 1R,2S)-1-[(tert-Butoxycbonyl)amino]-2-vinylcyclopropanecboxylic acid; VINYL ACCA; EOS-61403; VINYL ACCA //BP; Cyclopropanecboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, (1R,2S); 1-diMethylethoxy)carbonyl]amino]-2-ethenyl; (1R,2S)-1-Boc-2-vinylcyclopropanecboxylic acid; (1R,2S)-1-[[(1,1-diMethylethoxy)carbonyl]amino]-2-ethenyl-Cyclopropanecboxylic acid; (1R,2S)-1-[(tert-butoxycarbonyl)amino]-2-vinylcyclopropanecarboxylic acid

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 361.0±42.0 °C at 760 mmHg
• 分子式: C₁₁H₁₇NO₄
• 分子量: 227.257
• 闪点: 172.1±27.9 °C
• 精确质量: 227.115753
• PSA: 75.63000
• LogP: 1.33
• 外观性状: 固体;White to Light yellow to Light orange powder to crystal
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.508
• 储存条件: 0-10°C;存放于惰性气体之中;避免空气,加热

安全

• 危害码 (欧洲): Xi

合成路线

159622-09-0 ~99% 159622-10-3

文献：Gilead Sciences, Inc. Patent: US2009/47252 A1, 2009 ; Location in patent: Page/Page column 33-34 ;

1265883-97-3 ~99% 159622-10-3

文献：IDENIX PHARMACEUTICALS, INC.; PARSY, Christophe Claude; ALEXANDRE, Francois-Rene; LEROY, Frederic; CONVARD, Thierry; SURLERAUX, Dominique Patent: WO2011/17389 A1, 2011 ; Location in patent: Page/Page column 130 ; WO 2011/017389 A1

259217-95-3 ~96% 159622-10-3

文献：REF PHARMA, LLC.; COATS, Steven, J. Patent: WO2013/106689 A1, 2013 ; Location in patent: Page/Page column 24 ;

24424-99-5 1221174-69-1 ~71% 159622-10-3

文献：Kaneka Corporation Patent: EP2345633 A1, 2011 ; Location in patent: Page/Page column 12-13 ;

17447-60-8 ~% 159622-10-3

文献：Synthetic Communications, , vol. 24, # 20 p. 2873 - 2876

159622-08-9 ~% 159622-10-3

文献：Synthetic Communications, , vol. 24, # 20 p. 2873 - 2876

159700-59-1 ~% 159622-10-3

文献：Synthetic Communications, , vol. 24, # 20 p. 2873 - 2876

1221174-65-7 ~% 159622-10-3

文献：EP2345633 A1, ;

上下游产品

上游产品  6
159622-09-0 259217-95-3 24424-99-5 1221174-69-1
17447-60-8 1221174-65-7
下游产品  1
630421-48-6