80758-83-4

• 常用中文名：(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
• 常用英文名：(S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
• CAS号：80758-83-4
• 分子式：C₂₁H₁₆N₂O₅
• 分子量：376.36200
• 发布时间：2017-10-08 06:39:08
• 更新时间：2024-01-02 17:06:49

名称

• 英文名: camptothecin-7-aldehyde
• 英文别名: camptothecin-7-carbaldehyde; 7-formyl CPT; coptothecin-7-carbaldehyde; (S)-11-Formy-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; (20S)-camptothecin-7-carboxaldehyde; 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde,4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-,(S); 7-formyl camptothecin; (S)-4-Ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-11-carboxaldehyde

物化性质

• 密度: 1.54g/cm3
• 沸点: 817ºC at 760 mmHg
• 分子式: C₂₁H₁₆N₂O₅
• 分子量: 376.36200
• 闪点: 447.9ºC
• 精确质量: 376.10600
• PSA: 98.49000
• LogP: 1.89210
• 折射率: 1.744

合成路线

67-56-1 7689-03-4 ~% 80758-83-4

文献：SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. Patent: WO2009/16068 A1, 2009 ; Location in patent: Page/Page column 8 ;

80735-03-1 ~68% 80758-83-4

文献：Miyasaka, Tadashi; Sawada, Seigo; Nokata, Ken-ichiro Heterocycles, 1981 , vol. 16, # 10 p. 1719 - 1721

78287-14-6 103-80-0 ~19% 80758-83-4 78287-22-6

文献：Sawada; Nokata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2574 - 2580

84018-01-9 ~90% 80758-83-4

文献：Sawada; Nokata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2574 - 2580

7689-03-4 ~% 80758-83-4

文献：Sawada; Nokata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2574 - 2580

78287-14-6 ~67% 80758-83-4

文献：Sawada; Nokata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2574 - 2580

78287-14-6 64-19-7 ~68% 80758-83-4 78287-15-7

文献：Sawada; Nokata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2574 - 2580

84017-99-2 ~% 80758-83-4

文献：Ricci, Antonio; Marinello, Jessica; Bortolus, Marco; Sanchez, Albert; Grandas, Anna; Pedroso, Enrique; Pommier, Yves; Capranico, Giovanni; Maniero, Anna Lisa; Zagotto, Giuseppe Journal of Medicinal Chemistry, 2011 , vol. 54, # 4 p. 1003 - 1009

上下游产品

上游产品  8
67-56-1 7689-03-4 80735-03-1 78287-14-6
103-80-0 84018-01-9 64-19-7 84017-99-2
下游产品  1
84017-99-2