25376-45-8

• 常用中文名：2,4/2,6-二氨基甲苯
• 常用英文名：2,4/2,6-Diaminotoluene
• CAS号：25376-45-8
• 分子式：C₁₄H₂₀N₄
• 分子量：244.33500
• 发布时间：2018-03-07 08:00:00
• 更新时间：2024-01-06 10:15:22
• 1. 主要用作合成TDI的原料和聚醚起始剂。以TDA为起始剂合成的聚醚多元醇，制成的泡沫均匀细致，可以提高泡沫的隔热性能及低温尺寸性能。 2. 用作环氧树脂固化剂、染料中间体。 3. 合成用于聚氨酯弹性体以及环氧树脂的芳香族二胺固化剂：二甲硫基甲苯二胺DMTDA、二乙基甲苯二胺DETDA。

名称

• 中文名: 2,4/2,6-二氨基甲苯
• 英文名: 2,4/2,6-Diaminotoluene
• 英文别名: Methylphenylenediamine; 2,4-DICHLORO-2'-PIPERIDINOMETHYL BENZOPHENONE; ar-Methylbenzenediamine; NA-1709; ar-Methyl-1,3-benzenediamine; Benzenediamine,ar-methyl

物化性质

• 密度: 1.098g/cm3
• 沸点: 258.8ºC at 760 mmHg
• 熔点: 64ºC
• 分子式: C₁₄H₂₀N₄
• 分子量: 244.33500
• 闪点: 127.1ºC
• 精确质量: 244.16900
• PSA: 104.08000
• LogP: 4.64360
• 蒸汽压: 0.0134mmHg at 25°C
• 折射率: 1.64
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:2

  3.氢键受体数量:2

  4.可旋转化学键数量:0

  5.互变异构体数量:无

  6.拓扑分子极性表面积:52

  7.重原子数量:9

  8.表面电荷:0

  9.复杂度:92.9

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XS9445000 CHEMICAL NAME : Toluenediamine CAS REGISTRY NUMBER : 25376-45-8 LAST UPDATED : 199712 DATA ITEMS CITED : 13 MOLECULAR FORMULA : C7-H10-N2 MOLECULAR WEIGHT : 122.19 WISWESSER LINE NOTATION : ZR XZ X1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 270 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 29,395,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 463 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Lungs, Thorax, or Respiration - cyanosis Kidney, Ureter, Bladder - other changes in urine composition REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0544321 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 230 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 29,395,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 29,395,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 29,395,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 240 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 29,395,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 29,395,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2689 No. of Facilities: 15 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 29 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2689 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 413 (estimated)

安全

• 危险品运输编码: UN 2811
• 包装等级: III
• 危险类别: 6.1(b)