201809-22-5

• 常用中文名：6-[4-(叔丁氧羰酰)哌嗪-1-YL]烟酸
• 常用英文名：4-(5-CARBOXY-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS号：201809-22-5
• 分子式：C₁₅H₂₁N₃O₄
• 分子量：307.34500
• 发布时间：2018-06-13 22:35:18
• 更新时间：2026-07-29 12:57:48

名称

• 中文名: 6-[4-(叔丁氧羰酰)哌嗪-1-YL]烟酸
• 英文名: 6-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]pyridine-3-carboxylic acid
• 中文别名: 6-(4-叔-1-哌嗪基)吡啶-3-羧酸; 6-(4-(叔丁氧基羰基)哌嗪-1-基)烟酸; 4-(5-羧基-吡啶-2-基)-哌嗪-1-羧酸叔丁酯; 4-(5-羧基-吡啶-2-基)-哌嗪-1-甲酸叔丁酯; 6-{4-[((叔丁氧基)羰基]哌嗪-1-基}吡啶-3-羧酸; 4-(5-羧基-2-吡啶)-1-BOC-哌嗪
• 英文别名: 2-(4-BOC-Piperazino)pyridine-5-cboxylic acid; 4-(5-Cboxy-pyridin-2-yl)-piperazine-1-cboxylic acid tert-butyl ester; 4-(5-Carboxy-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester; 6-[4-(TERT-BUTOXYCBONYL)PIPERAZIN-1-YL]NICOTINIC ACID; 6-(4-Boc-piperazin-1-yl)pyridine-3-cboxylic acid; N4-BOC-6-PIPERAZIN-1-YLNICOTINIC ACID; 6-[4-(tert-Butoxycbonyl)piperazin-1-yl]nicotinicacid; 6-(4-Boc-1-piperazinyl)pyridine-3-cboxylic acid; 6-[4-(tert-Butoxycbonyl)piperazin-1-yl]pyridine-3-cboxylic acid; 1-(1,1-Dimethylethyl) 4-(5-cboxy-2-pyridinyl)-1-piperazinecboxylate; 1-Piperazinecboxylicacid, 4-(5-cboxy-2-pyridinyl)-, 1-(1,1-dimethylethyl) ester; 6-Piperazin-1-ylnicotinic acid, N4-BOC protected; Boc-piperazine-pyridine-COOH; 6-[4-(tert-butoxycarbonyl)piperazin-1-yl]nicotinic acid; 6-[4-(PIPERAZIN-1-YL)]NICOTINIC ACID, N4-BOC PROTECTED; 6-[4-(tert-butoxycbonyl)piperazino]nicotinic acid

物化性质

• 密度: 1.148g/cm3
• 沸点: 497.4ºC at 760 mmHg
• 熔点: 198ºC
• 分子式: C₁₅H₂₁N₃O₄
• 分子量: 307.34500
• 闪点: 254.6ºC
• 精确质量: 307.15300
• PSA: 82.97000
• LogP: 1.83980
• 折射率: 1.507
• 储存条件: 室温

安全

• 危害码 (欧洲): Xi

合成路线

201809-20-3 ~% 201809-22-5

文献：WO2009/55077 A1, ; Page/Page column 374-375 ;

5326-23-8 57260-71-6 ~% 201809-22-5

文献：US2012/184520 A1, ; Page/Page column 20 ;

73781-91-6 57260-71-6 ~% 201809-22-5

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 17 p. 5205 - 5208

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