56243-25-5

• 常用中文名：1-苄基-4-氰基-4-苯基哌啶盐酸盐
• 常用英文名：1-Benzyl-4-phenylpiperidine-4-carbonitrile
• CAS号：56243-25-5
• 分子式：C₁₉H₂₁ClN₂
• 分子量：312.83600
• 发布时间：2018-12-25 22:06:59
• 更新时间：2024-01-03 18:09:08

名称

• 中文名: 1-苄基-4-氰基-4-苯基哌啶盐酸盐
• 英文名: 1-Benzyl-4-Cyano-4-Phenylpiperidine Hydrochloride
• 中文别名: 1-苯甲基-4-氰-4-苯基哌啶; 1-苯甲基-4-氰-4-苯基哌啶盐酸盐
• 英文别名: 1-benzyl-4-phenylpiperidine-4-carbonitrile; MFCD00044826

物化性质

• 密度: 1.12g/cm3
• 沸点: 430.4ºC at 760mmHg
• 熔点: 250-259ºC
• 分子式: C₁₉H₂₁ClN₂
• 分子量: 312.83600
• 闪点: 184.3ºC
• 精确质量: 312.13900
• PSA: 27.03000
• LogP: 4.48388
• 储存条件: 室温，干燥

MSDS

Name: 1-Benzyl-4-Cyano-4-Phenylpiperidine Hydrochloride 99+% Material Safety Data Sheet Synonym: 4-Phenyl-1-(Phenylmethyl)-4-Piperidinecarbonitrile CAS: 56243-25-5 Section 1 - Chemical Product MSDS Name:1-Benzyl-4-Cyano-4-Phenylpiperidine Hydrochloride 99+% Material Safety Data Sheet Synonym:4-Phenyl-1-(Phenylmethyl)-4-Piperidinecarbonitrile Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 56243-25-5 1-Benzyl-4-Cyano-4-Phenylpiperidine Hy 99+ unlisted Hazard Symbols: XN Risk Phrases: 20/21/22 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Harmful by inhalation, in contact with skin and if swallowed.The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration. Ingestion: May cause irritation of the digestive tract. May cause cardiac disturbances. The toxicological properties of this substance have not been fully investigated. May cause central nervous system depression. Metabolism may release cyanide, which may result in headache, dizziness, weakness, collapse, unconsciousness and possible death. Ingestion may result in symptoms similar to cyanide poisoning which is characterized by asphyxiation. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May cause cardiac abnormalities. May be metabolized to cyanide which in turns act by inhibiting cytochrome oxidase impairing cellular respiration. Inhalation may result in symptoms similar to cyanide poisoning which include tachypnea, hyperpnea (abnormally rapid or deep breathing), and dyspnea (labored breathing) followed rapidly by respiratory depression. Pulmonary edema may occur. Inhalation at high concentrations may cause CNS depression and asphixiation. Chronic: No information found. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration. Chronic exposure to cyanide solutions may lead to the development of a "cyanide" rash, characterized by itching, and by macular, papular, and vesicular eruptions, and may be accompanied by secondary infections. Exposure to small amounts of cyanide compounds over long periods of time is reported to cause loss of appetite, headache, weakness, nausea, dizziness, and symptoms of irritation of the upper respiratory tract and eyes. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. Notes to Physician: May be partially metabolized to cyanide in the body. Antidote: Always have a cyanide antidote kit on hand when working with cyanide compounds. Get medical advice to use. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. Extinguishing Media: Use agent most appropriate to extinguish fire. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels. Exposure Limits CAS# 56243-25-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: very light beige Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 250.00 - 259.00 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C19H20N2.HCl Molecular Weight: 312.83 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, excess heat, strong oxidants. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 56243-25-5 unlisted. LD50/LC50: Not available. Carcinogenicity: 1-Benzyl-4-Cyano-4-Phenylpiperidine Hydrochloride - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.* Hazard Class: 6.1 UN Number: 2811 Packing Group: III IMO Shipping Name: TOXIC SOLID, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: 2811 Packing Group: III RID/ADR Shipping Name: TOXIC SOLID, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: 2811 Packing group: III Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 56243-25-5: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 56243-25-5 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 56243-25-5 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 风险声明 (欧洲): 20/21/22
• 安全声明 (欧洲): S45
• 海关编码: 2933399090

合成路线

55-51-6 140-29-4 ~86% 56243-25-5

文献：Thompson, Doug; Reeves, Perry C. Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 771 - 772

40481-13-8 100-39-0 ~% 56243-25-5

文献：US5968953 A1, ;

100-39-0 51304-58-6 ~% 56243-25-5

文献：US5861417 A1, ; US 5861417 A

40481-13-8 ~% 56243-25-5

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 5 p. 1160 - 1162

100119-73-1 100-46-9 ~% 56243-25-5

文献：DE882403 , ; DRP/DRBP Org.Chem. US2398575 , ;

10469-27-9 ~% 56243-25-5

文献：US2398575 , ;

101-32-6 ~% 56243-25-5

文献：Chemische Berichte, , vol. 74, p. 1433,1449

上下游产品

上游产品  9
55-51-6 140-29-4 40481-13-8 100-39-0
51304-58-6 100119-73-1 100-46-9 10469-27-9
101-32-6
下游产品  8
26979-21-5 77-17-8 59084-08-1 83898-31-1
84176-76-1 84176-77-2 61886-17-7 40481-13-8

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%