122795-43-1

• 常用中文名：钆双胺一水物
• 常用英文名：Gadodiamide
• CAS号：122795-43-1
• 分子式：C₁₆H₂₈GdN₅O₉
• 分子量：591.67200
• 相关类别： 原料药 诊断用药 影象检查用药
• 发布时间：2018-03-06 08:00:00
• 更新时间：2026-07-13 18:02:10
• Gadodiamide是造影剂,用于MR中血管成像。

名称

• 中文名: 钆双胺一水物
• 英文名: gadodiamide hydrate
• 中文别名: 5,8-双(羧基甲基)-11-[2- (甲氨基)-2-氧乙基]-3-氧-2,5,8,11-四氮杂十三烷-13-酸]钆X水合物; 钆双胺水合物; 5,8-双(羧甲基)-2-[2-(甲胺基)-2-氧乙基]-10-氧代-2,5,8,11-四氮杂癸烷-1-羧酸钆一水物; 钆双胺一水合物
• 英文别名: Gadolinium 5,8-bis(cboxylatomethyl)-2-[2-(methylamino)-2-oxoethyl]-10-oxo-2,5,8,11-tetraazadodecane-1-cboxylate hydrate; Omniscan; Gadolinium, aqua[5,8-bis(cboxymethyl)-11-[2-(methylamino)-2-oxoethyl]-3-oxo-2,5,8,11-tetraazatridecan-13-oato(3-)]-, hydrate; 5,8-Bis(cboxymethyl)-11-[2-(methylamino)-2-oxoethyl]-3-oxo-2,5,8,11-tetraazatridecan-13-oato]Gadolinium xhydrate; (TPS-9-156428397)-aqua[rel-(5R,11S)-5,8-bis[(cboxy-κO)methyl]-11-[2-(methylamino)-2-(oxo-κO)ethyl]-3-(oxo-κO)-2,5,8,11-tetraazatridecan-13-oato(3-)-κN5,κN8,κN11,κO13]-gadolinium,hydrate (1:x); 2-[bis[2-[[2-(methylamino)-2-oxoethyl]-(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate; 2-[bis[2-[[2-keto-2-(methylamino)ethyl]-(2-keto-2-oxido-ethyl)amino]ethyl]amino]acetate; Gadodiamide //BP; 2-[bis[2-[[2-(methylamino)-2-oxo-ethyl]-(2-oxidanidyl-2-oxo-ethyl)amino]ethyl]amino]ethanoate; Gadodiamide, >=; Gadodiamide hydrate; 2-[bis[2-[carboxylatomethyl-[2-(methylamino)-2-oxoethyl]amino]ethyl]amino]acetate,gadolinium(3+),hydrate; GadodiaMide(OMniscan)

物化性质

• 沸点: 769.1ºC at 760mmHg
• 分子式: C₁₆H₂₈GdN₅O₉
• 分子量: 591.67200
• 闪点: 419ºC
• 精确质量: 592.11300
• PSA: 156.05000
• 外观性状: 粉末
• 储存条件: -20℃

生物活性

• 描述: Gadodiamide是造影剂,用于MR中血管成像。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
• 参考文献:

  [1]. Canavese, C., et al., Gadolinium-associated nephrogenic systemic fibrosis: the need for nephrologists' awareness. J Nephrol, 2008. 21(3): p. 324-36.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LW3937500 CHEMICAL NAME : Gadolinium, aqua(5,8-bis(carboxymethyl)-11-(2-(methylamino)-2-oxo ethyl)- 3-oxo-2,5,8,11-tetraazatridecan-13-oato(3-))-, hydrate CAS REGISTRY NUMBER : 122795-43-1 LAST UPDATED : 199607 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C16-H28-Gd-N5-O9.xH2-O MOLECULAR WEIGHT : 717.88 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 16269 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - biochemical and metabolic REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 14,78,1994