Gadodiamide

Modify Date: 2024-01-08 00:42:15

Gadodiamide Structure
Gadodiamide structure
Common Name Gadodiamide
CAS Number 122795-43-1 Molecular Weight 591.67200
Density N/A Boiling Point 769.1ºC at 760mmHg
Molecular Formula C16H28GdN5O9 Melting Point N/A
MSDS N/A Flash Point 419ºC

 Use of Gadodiamide


Gadodiamide is a gadolinium-based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. Target: OthersGadodiamide(Omniscan) is a gadolinium-based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. Gadodiamide is a contrast medium for cranial and spinal magnetic resonance imaging (MRI) and for general MRI of the body after intravenous administration. The product provides contrast enhancement and facilitates visualisation of abnormal structures or lesions in various parts of the body including the central nervous system (CNS). A recent review takes the question of toxicity caused by loss of gadolinium from the complex. "The challenge for nephrologists includes (a) evidence of transmetallation, such as gadolinium deposits in bone, increased urinary zinc excretion, iron-transferrin dissociation or 'spurious hypocalcemia' in exposed people" [1].

 Names

Name gadodiamide hydrate
Synonym More Synonyms

 Gadodiamide Biological Activity

Description Gadodiamide is a gadolinium-based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. Target: OthersGadodiamide(Omniscan) is a gadolinium-based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. Gadodiamide is a contrast medium for cranial and spinal magnetic resonance imaging (MRI) and for general MRI of the body after intravenous administration. The product provides contrast enhancement and facilitates visualisation of abnormal structures or lesions in various parts of the body including the central nervous system (CNS). A recent review takes the question of toxicity caused by loss of gadolinium from the complex. "The challenge for nephrologists includes (a) evidence of transmetallation, such as gadolinium deposits in bone, increased urinary zinc excretion, iron-transferrin dissociation or 'spurious hypocalcemia' in exposed people" [1].
Related Catalog
References

[1]. Canavese, C., et al., Gadolinium-associated nephrogenic systemic fibrosis: the need for nephrologists' awareness. J Nephrol, 2008. 21(3): p. 324-36.

 Chemical & Physical Properties

Boiling Point 769.1ºC at 760mmHg
Molecular Formula C16H28GdN5O9
Molecular Weight 591.67200
Flash Point 419ºC
Exact Mass 592.11300
PSA 156.05000
Storage condition -20℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LW3937500
CHEMICAL NAME :
Gadolinium, aqua(5,8-bis(carboxymethyl)-11-(2-(methylamino)-2-oxo ethyl)- 3-oxo-2,5,8,11-tetraazatridecan-13-oato(3-))-, hydrate
CAS REGISTRY NUMBER :
122795-43-1
LAST UPDATED :
199607
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H28-Gd-N5-O9.xH2-O
MOLECULAR WEIGHT :
717.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
16269 mg/kg
SEX/DURATION :
female 7-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 14,78,1994

 Synonyms

Gadodiamide hydrate
Omniscan
2-[bis[2-[carboxylatomethyl-[2-(methylamino)-2-oxoethyl]amino]ethyl]amino]acetate,gadolinium(3+),hydrate
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