177-11-7

• 常用中文名：4-哌啶酮缩乙二醇
• 常用英文名：4-Piperidone-ethylene ketal
• CAS号：177-11-7
• 分子式：C₇H₁₃NO₂
• 分子量：143.18
• 发布时间：2018-03-31 08:00:00
• 更新时间：2025-08-24 08:56:36
• 1,4-二恶-8-氮杂螺[4.5]癸烷是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

名称

• 中文名: 4-哌啶酮缩乙二醇
• 英文名: 1,4-Dioxa-8-azaspiro[4.5]decane
• 中文别名: 4-哌啶酮乙烯缩酮; 1,4-二叠氮-8-壬烯
• 英文别名: piperidin-4-one ethylene ketal; 4-PIPERIDONE ETHYL HEMIKETAL; EINECS 205-868-6; 4-Piperidone ethylene acetal; 1,4-Dioxa-8-azaspiro(4.5)decane; 4-Piperidone-ethylene ketal; 4-Piperidinone ethyl ketal; Piperidone-4-ethyleneketal; 4,4-ethylenedioxypiperidine; 1,4-Dioxa-8-azaspiro[4.5]decane; MFCD00005976; 4-piperidone ethylene ketal; 1,4-dioxa-8-azaspirodecane; 4-Piperidoneethyleneketal; 1,4-dioxa-8-azaspiro[4,5]decane

物化性质

• 密度: 1.117
• 沸点: 108-110 ºC (26 mmHg)
• 分子式: C₇H₁₃NO₂
• 分子量: 143.18
• 闪点: 81 ºC
• 精确质量: 143.094635
• PSA: 30.49000
• LogP: 0.09
• 外观性状: 无色至黄色液体
• 蒸汽压: 0.2±0.4 mmHg at 25°C
• 折射率: 1.499
• 储存条件: 存放于惰性气体之中;避免湿气 (分解)
• 水溶解性: 水溶性：完全混溶；混溶：丙酮,乙醇
• 分子结构:

  1、 摩尔折射率：37.51

  2、 摩尔体积（cm³/mol）：127.8

  3、 等张比容（90.2K）：316.5

  4、 表面张力（dyne/cm）: 37.6

  5、 介电常数：无可用

  6、 偶极距（10 ^-24cm ³）：无可用

  7、 极化率：14.87

• 计算化学:

  1.疏水参数计算参考值（XlogP）:-0.3

  2.氢键供体数量:1

  3.氢键受体数量:3

  4.可旋转化学键数量:0

  5.互变异构体数量:无

  6.拓扑分子极性表面积30.5

  7.重原子数量:10

  8.表面电荷:0

  9.复杂度:113

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 密度（g/mL,25/4℃）：1.117g/mLat 20°C(lit.)

  2. 沸点（ºC,常压）： 108-111°C26mm Hg(lit.)

  3. 折射率：n20/D 1.4819(lit.)

  4. 闪点（ºC）：179°F

生物活性

• 描述: 1,4-二恶-8-氮杂螺[4.5]癸烷是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。
• 相关类别:
  研究领域 >> 其他
• 体外研究: 4-哌啶酮乙烯缩酮用于合成 1,4-二氧-8-氮杂螺[4,5]十碳螺环三磷腈

MSDS

Name: 1 4-Dioxa-8-azaspiro(4.5)decane 98% Material Safety Data Sheet Synonym: 4-Piperidone ethylene keta CAS: 177-11-7 Section 1 - Chemical Product MSDS Name:1 4-Dioxa-8-azaspiro(4.5)decane 98% Material Safety Data Sheet Synonym:4-Piperidone ethylene keta Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 177-11-7 1,4-Dioxa-8-azaspiro[4.5]decane 98 205-868-6 Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. May cause chemical conjunctivitis and corneal damage. Skin: Causes skin irritation. May cause dermatitis. May cause cyanosis of the extremities. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Inhalation: Causes respiratory tract irritation. Aspiration may lead to pulmonary edema. Inhalation at high concentrations may cause CNS depression and asphixiation. Chronic: Effects may be delayed. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible liquid. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated. Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust. Use a spark-proof tool. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels. Exposure Limits CAS# 177-11-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Clear liquid Color: colorless to yellow Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: 108.0 - 110.0 deg C @ 26.00mm Freezing/Melting Point: Not available. Autoignition Temperature: Not applicable. Flash Point: 81 deg C ( 177.80 deg F) Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Not available. Solubility in water: Not available. Specific Gravity/Density: 1.1170g/cm3 Molecular Formula: C7H13NO2 Molecular Weight: 143.19 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Incompatible materials, ignition sources, excess heat, strong oxidants. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 177-11-7 unlisted. LD50/LC50: Not available. Carcinogenicity: 1,4-Dioxa-8-azaspiro[4.5]decane - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 177-11-7: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 177-11-7 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 177-11-7 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi:Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S36-S24/25
• WGK德国: 3
• 海关编码: 29349990

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海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%