4461-39-6

• 常用中文名：2-羟乙胺丙胺
• 常用英文名：N-(2-Hydroxyethyl)-1,3-propanediamine
• CAS号：4461-39-6
• 分子式：C₅H₁₄N₂O
• 分子量：118.177
• 发布时间：2018-12-17 09:51:32
• 更新时间：2024-01-02 19:18:19
• 下载msds

名称

• 中文名: 2-羟乙胺丙胺
• 英文名: 2-(3-Aminopropylamino)ethanol
• 中文别名: N-羟乙基-1,3-丙二胺; N-(2-羟乙基)-1,3-丙二胺
• 英文别名: 2-[(3-Aminopropyl)amino]ethanol; Ethanol, 2-[(3-aminopropyl)amino]-; MFCD00025617; N-(2-Hydroxyethyl)-1,3-Propanediamine; 1,3-DIAMINO-N-(2-HYDROXYETHYL)-PROPANE; 2-((3-Aminopropyl)amino)ethanol; EINECS 224-718-0

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 240.7±15.0 °C at 760 mmHg
• 熔点: 15-19 °C
• 分子式: C₅H₁₄N₂O
• 分子量: 118.177
• 闪点: 99.4±20.4 °C
• 精确质量: 118.110611
• PSA: 58.28000
• LogP: -1.32
• 外观性状: 透明无色液体
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.472
• 储存条件:

  避光，通风干燥处，密封保存

• 稳定性:

  常温常压下稳定，浅色透明液体，易溶于水。

• 水溶解性: miscible
• 分子结构:

  1、 摩尔折射率：33.87

  2、 摩尔体积（m³/mol）：121.0

  3、 等张比容（90.2K）：304.8

  4、 表面张力（dyne/cm）：40.1

  5、 极化率（10 ^-24cm ³）：13.43

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：-1.5.

  2、 氢键供体数量：3

  3、 氢键受体数量：3

  4、 可旋转化学键数量：5

  5、 拓扑分子极性表面积（TPSA）：58.3

  6、 重原子数量：8

  7、 表面电荷：0

  8、 复杂度：41.4

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：0

  11、 不确定原子立构中心数量：0

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：1

• 更多:

  1. 性状：不确定

  2. 密度：不确定

  3. 相对蒸汽密度（g/mL,空气=1）：不确定

  4. 熔点（ºC）：不确定

  5. 沸点（ºC,常压）：不确定

  6. 沸点（ºC,0.9mmHg）：不确定

  7. 折射率：不确定

  8. 闪点（ºC）：不确定

  9. 比旋光度（º）：不确定

  10. 自燃点或引燃温度（ºC）：不确定

  11. 蒸气压（kPa,25ºC）：不确定

  12. 饱和蒸气压（kPa,60ºC）：不确定

  13. 燃烧热（KJ/mol）：不确定

  14. 临界温度（ºC）：不确定

  15. 临界压力（KPa）：不确定

  16. 油水（辛醇/水）分配系数的对数值：不确定

  17. 爆炸上限（%,V/V）：不确定

  18. 爆炸下限（%,V/V）：不确定

  19. 溶解性：不确定

MSDS

Name: N-(2-Hydroxyethyl)-1 3-propanediamine 97+% Material Safety Data Sheet Synonym: None known CAS: 4461-39-6 Section 1 - Chemical Product MSDS Name:N-(2-Hydroxyethyl)-1 3-propanediamine 97+% Material Safety Data Sheet Synonym:None known Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 4461-39-6 N-(2-Hydroxyethyl)-1,3-propanediamine 97+ 224-718-0 Hazard Symbols: C Risk Phrases: 35 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Causes severe burns.Corrosive.The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: Causes eye burns. May cause chemical conjunctivitis and corneal damage. Skin: Causes skin burns. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color. Ingestion: May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. The toxicological properties of this substance have not been fully investigated. May cause systemic effects. Inhalation: Causes chemical burns to the respiratory tract. The toxicological properties of this substance have not been fully investigated. May cause systemic effects. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Get medical aid. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes). Skin: Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes. Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated. Extinguishing Media: Use foam, dry chemical, or carbon dioxide. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Avoid contact with eyes, skin, and clothing. Do not breathe dust, vapor, mist, or gas. Keep container tightly closed. Avoid ingestion and inhalation. Do not ingest or inhale. Use only in a chemical fume hood. Discard contaminated shoes. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 4461-39-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Liquid Color: clear, colorless Odor: None reported. pH: 11-12 (20g/L aq. soln) Vapor Pressure: <0.1 mbar @ 20 Viscosity: 164 mPas 20 deg C Boiling Point: 255 deg C @ 760.00mm Hg Freezing/Melting Point: 15-19 deg C Autoignition Temperature: 325 deg C ( 617.00 deg F) Flash Point: 152 deg C ( 305.60 deg F) Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: >250 deg C Solubility in water: miscible Specific Gravity/Density: 1.0070g/cm3 Molecular Formula: C5H14N2O Molecular Weight: 118.20 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Moisture, excess heat. Incompatibilities with Other Materials: Acidic conditions, acids, strong oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides (NOx) and ammonia (NH3). Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 4461-39-6 unlisted. LD50/LC50: Not available. Carcinogenicity: N-(2-Hydroxyethyl)-1,3-propanediamine - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: POLYAMINES, LIQUID, CORROSIVE, N.O.S.* Hazard Class: 8 UN Number: 2735 Packing Group: II IMO Shipping Name: POLYAMINES, LIQUID, CORROSIVE, N.O.S. Hazard Class: 8 UN Number: 2735 Packing Group: II RID/ADR Shipping Name: POLYAMINES, LIQUID, CORROSIVE, N.O.S. Hazard Class: 8 UN Number: 2735 Packing group: II Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: C Risk Phrases: R 35 Causes severe burns. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 4461-39-6: 2 Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 4461-39-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 4461-39-6 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 通常对水是不危害的，若无政府许可，勿将材料排入周围环境

安全

• 符号: GHS05
• 信号词: Danger
• 危害声明: H314
• 警示性声明: P280-P305 + P351 + P338-P310
• 个人防护装备: Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
• 危害码 (欧洲): C:Corrosive;
• 风险声明 (欧洲): R35
• 安全声明 (欧洲): S26-S36/37/39-S45
• 危险品运输编码: UN 2735 8/PG 3
• WGK德国: 3
• 包装等级: III
• 危险类别: 8
• 海关编码: 29221980

合成路线

33759-44-3 ~% 4461-39-6

文献：Surrey; Hammer Journal of the American Chemical Society, 1950 , vol. 72, p. 1814

75-21-8 109-76-2 ~60% 4461-39-6 10563-27-6

文献：Oiry, J.; Pue, J. Y.; Laval, J. D.; Fatome, M.; Imbach, J. L. European Journal of Medicinal Chemistry, 1995 , vol. 30, # 1 p. 47 - 52

503-29-7 141-43-5 ~% 4461-39-6

文献：Bobylev, V. A.; Veselkov, N. Yu.; Dalin, A. R.; Sharikov, F. Yu. J. Gen. Chem. USSR (Engl. Transl.), 1991 , vol. 61, # 8.2 p. 1841 - 1856,1700 - 1713

上下游产品

上游产品  5
33759-44-3 75-21-8 109-76-2 503-29-7
141-43-5
下游产品  5
505-66-8 23545-42-8 37020-26-1 5418-53-1
5451-44-5

海关

海关编码	2922199090
中文概述	2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%