前往化源商城

7411-49-6

7411-49-6结构式
7411-49-6结构式

化源商城直购

中文名 3,3'-二氨基联苯胺四盐酸盐
英文名 3,3',4,4'-Biphenyltetramine tetrahydrochloride
中文别名 3,3'-二氨基联苯氨四盐酸盐
3,3''-二氨基联苯胺四盐酸盐
3,3’-二氨基联苯胺,盐酸盐
英文别名 DAB TABLET
DAB SUBSTRATE
DAB-HCL
Biphenyl-3,3',4,4'-tetramine tetrahydrochloride
DAB TETRAHYDROCHLORIDE
DAB
3,3',4,4'-Biphenyltetramine tetrahydrochloride
DAB,tetrahydrochloride3
3,3`-Diaminobenzidine tetrahydrochloride
DAB EASY tablets
DAB anhydrous
MFCD00012969
[1,1'-Biphenyl]-3,3',4,4'-tetramine, hydrochloride (1:4)
DAB 4HCL
EINECS 231-018-9
DAB WITH METAL ENHANCER
描述 3,3'-Diaminobenzidine(DAB)是有机化合物,具有化学和热力学稳定性,可用于核酸和蛋白的免疫组化染色。
相关类别
参考文献

[1]. Hannetz Roschzttardtz, et al. Plant Cell Nucleolus as a Hot Spot for Iron.

沸点 481.7ºC at 760 mmHg
熔点 300°C
分子式 C12H18Cl4N4
分子量 360.110
闪点 282.7ºC
精确质量 358.028564
PSA 104.08000
LogP 7.21520
外观性状 灰色至紫色-棕色粉末
储存条件

密封于2-8℃阴凉干燥环境。

稳定性

如果遵照规格使用和储存则不会分解。

水溶解性 Soluble
分子结构

1、摩尔折射率:无可用

2、 摩尔体积(cm3/mol): 无可用

3、 等张比容(90.2K):无可用

4、 表面张力(dyne/cm):无可用

5、 极化率:无可用

计算化学

1、 疏水参数计算参考值(XlogP):无可用

2、 氢键供体数量:8

3、 氢键受体数量:4

4、 可旋转化学键数量:1

5、 拓扑分子极性表面积(TPSA):104

6、 重原子数量:20

7、 表面电荷:0

8、 复杂度:209

9、 同位素原子数量:0

10、 确定原子立构中心数量:0

11、 不确定原子立构中心数量:0

12、 确定化学键立构中心数量:0

13、 不确定化学键立构中心数量:0

14、 共价键单元数量:5

更多

1. 性状:无可用

2. 密度(g/mL,25/4℃): 无可用

3. 相对蒸汽密度(g/mL,空气=1):无可用

4. 熔点(ºC):125

5. 沸点(ºC,常压):无可用

6. 沸点(ºC,5.2kPa): 无可用

7. 折射率: 无可用

8. 闪点(ºC): 无可用

9. 比旋光度(º):无可用

10. 自燃点或引燃温度(ºC):无可用

11. 蒸气压(kPa,25ºC):无可用

12. 饱和蒸气压(kPa,60ºC):无可用

13. 燃烧热(KJ/mol):无可用

14. 临界温度(ºC):无可用

15. 临界压力(KPa):无可用

16. 油水(辛醇/水)分配系数的对数值:无可用

17. 爆炸上限(%,V/V):无可用

18. 爆炸下限(%,V/V): 无可用

19. 溶解性:可溶于水

Name: 3 3 -Diaminobenzidine tetrahydrochloride dihydrate 98% Material Safety Data Sheet
Synonym: 3,3',4,4'-Biphenyltetramine tetrahydrochloride; 3,3',4,4'-Tetraaminobiphenyl tetrahydrochloride
CAS: 7411-49-6
Section 1 - Chemical Product MSDS Name:3 3 -Diaminobenzidine tetrahydrochloride dihydrate 98% Material Safety Data Sheet
Synonym:3,3',4,4'-Biphenyltetramine tetrahydrochloride; 3,3',4,4'-Tetraaminobiphenyl tetrahydrochloride

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
7411-49-6 3,3'-Diaminobenzidine tetrahydrochlori 98 231-018-9
Hazard Symbols: XI
Risk Phrases: 33 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Danger of cumulative effects. Irritating to eyes, respiratory system and skin.Cancer suspect agent.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed. Animal studies have reported the development of tumors. Potential cancer hazard.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Minimize dust generation and accumulation.
Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4C/39F.)

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 7411-49-6: United States OSHA: (Cancer suspect agent - see 29 CFR 1910.1010) (listed under Benzidine).
France - VME: (listed as benzidine): 0.001 ppm VME; 0.008 mg/m3 V Germany: (listed as benzidine): 0.001 ppm VME; 0.008 mg/m3 VME Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: off-white to gray
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 280 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C12H14N4.4HCl.2H2O
Molecular Weight: 396.14

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, strong oxidants, strong oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 7411-49-6: DV8753000 LD50/LC50:
Not available.
Carcinogenicity:
3,3'-Diaminobenzidine tetrahydrochloride - California: carcinogen, initial date 2/27/87 (listed as Benzidine).
NTP: Known carcinogen (listed as Benzidine).
IARC: Group 1 carcinogen (listed as Benzidine).
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 33 Danger of cumulative effects.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 22 Do not breathe dust.
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 7411-49-6: No information available.
Canada
CAS# 7411-49-6 is listed on Canada's DSL List.
CAS# 7411-49-6 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 7411-49-6 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

毒理学数据:

1 。
试验方法:口服
摄入剂量: 260 mg/kg/78W-C
测试对象:啮齿动物-鼠
毒性类型:瘤
毒性作用: 1.模棱两可瘤代理RTECS标准
2.肝脏肿瘤
2 。
试验方法:口服
摄入剂量: 260 mg/kg/78W-C
测试对象:啮齿动物-鼠
毒性类型:瘤
毒性作用: 1.肿瘤

2.肺 ,胸部或呼吸-肿瘤

3 。
试验方法:口服
摄入剂量: 520 mg/kg/78W-C
测试对象:啮齿动物-鼠
毒性类型:瘤
毒性作用: 1. 肿瘤

2.肺,胸部或呼吸-肿瘤

4 。
试验方法:腹腔
摄入剂量: 330毫克/千克
测试对象:啮齿动物-鼠
毒性类型:急性
毒性作用: 详细的毒副作用没有报告以外的其他致死剂量值

生态学数据:

该物质对环境可能有危害,对水体应给予特别注意。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DV8753000
CHEMICAL NAME :
3,3',4,4'-Biphenyltetramine, tetrahydrochloride
CAS REGISTRY NUMBER :
7411-49-6
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C12-H14-N4.4Cl-H
MOLECULAR WEIGHT :
360.14
WISWESSER LINE NOTATION :
ZR BZ DR CZ DZ &GH 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
330 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCIBR* Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial Ave., Cambridge, MA 02141) Volume(issue)/page/year: NCI-E-68-1311,1973 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
260 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
260 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
520 gm/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 2(2),325,1978

符号 GHS07 GHS08
GHS07, GHS08
信号词 Danger
危害声明 H302-H319-H341-H350
警示性声明 P201-P280-P301 + P312 + P330-P305 + P351 + P338-P308 + P313-P337 + P313
危害码 (欧洲) Xn:Harmful;
风险声明 (欧洲) R22;R36/37/38;R40
安全声明 (欧洲) S7-S16-S24-S33-S36/37-S45-S24/25-S22
危险品运输编码 UN 3316 9/PG 2
WGK德国 3
RTECS号 DV8753000
危险类别 9.0