524-14-1

524-14-1结构式

中文名	丙二酰辅酶A·钠盐 MALONY-COA
英文名	malonyl-CoA
中文别名	猪丙二酰辅酶A(MALONYLCOA)ELISA试剂盒 2,6-二氧代环己烷甲醛鸡丙二酰辅酶A(MALONYCOA)ELISA试剂盒丙二酰辅酶A-钠盐丙二酰辅酶A(钠盐或锂盐)
英文别名	Malonyl Coenzyme A S-(hydrogen malonyl)coenzyme A Malonyl-CoA-sodium-salt Adenosine 5'-[diphosphoric acid β-[(R)-4-[[2-[[2-(cboxyacetylthio)ethyl]cbamoyl]ethyl]amino]-4-oxo-3-hydroxy-2,2-dimethylbutyl]]3'-phosphoric acid 3-[2-[3-[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]aminopropanoylamino]ethylsulfanyl]-3-oxo-propanoic acid 2,6-Dioxo-cyclohexancarbaldehyd 2-formyl-1,3-cyclohexanedione 3-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-3-oxopropanoicacid malony-coa coenzyme A malonyl derivative, tetralithium salt S-(HYDROGEN MALONYL)COENZYME A 2,6-dioxo-cyclohexanecarbaldehyde S-Malonyl-CoA S-(Cboxyacetyl)coenzyme A Malonyl-CoA Coenzyme A, S-(hydrogen propanedioate)

描述	丙二酰辅酶a是脂肪酸生物合成的底物和脂肪酸氧化的抑制剂。丙二酰辅酶a也是线粒体肉碱棕榈酰转移酶(CPT)的可逆抑制剂[1][2]。
相关类别	研究领域 >> 代谢疾病
靶点	Human Endogenous Metabolite
体外研究	丙二酰辅酶A(20μM,6分钟) 抑制 MCF-7型细胞每分钟1次活性 (降低 75%)[2]. 丙二酰辅酶A(0-3μM)抑制雌性大鼠肝线粒体中的每分钟1次活性[3].
参考文献	[1]. Folmes CD, et L. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc Res. 2007 Jan 15;73(2):278-87. [2]. Thupari JN, et al. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun. 2001 Jul 13;285(2):217-23. [3]. Zammit VA. Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro. Biochem J. 1983 Mar 15;210(3):953-6.