524-14-1

524-14-1结构式

英文名	malonyl-CoA
英文别名	2,6-Dioxo-cyclohexancarbaldehyd 2-formyl-1,3-cyclohexanedione 2,6-dioxo-cyclohexanecarbaldehyde S-(HYDROGEN MALONYL)COENZYME A 3-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-3-oxopropanoicacid S-(HYDROGEN MALONYL)COENZYME A

描述	丙二酰辅酶a是脂肪酸生物合成的底物和脂肪酸氧化的抑制剂。丙二酰辅酶a也是线粒体肉碱棕榈酰转移酶(CPT)的可逆抑制剂[1][2]。
相关类别	研究领域 >> 代谢疾病
靶点	Human Endogenous Metabolite
体外研究	丙二酰辅酶A(20μM,6分钟) 抑制 MCF-7型细胞每分钟1次活性 (降低 75%)[2]. 丙二酰辅酶A(0-3μM)抑制雌性大鼠肝线粒体中的每分钟1次活性[3].
参考文献	[1]. Folmes CD, et L. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc Res. 2007 Jan 15;73(2):278-87. [2]. Thupari JN, et al. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun. 2001 Jul 13;285(2):217-23. [3]. Zammit VA. Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro. Biochem J. 1983 Mar 15;210(3):953-6.