Malonyl CoA

Modify Date: 2025-08-23 16:57:41

Malonyl CoA structure	Common Name	Malonyl CoA
	CAS Number	524-14-1	Molecular Weight	853.58000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₈N₇O₁₉P₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Malonyl CoA

Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1[1][2].

Name	malonyl-CoA
Synonym	More Synonyms

Description	Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1[1][2].
Related Catalog	Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	丙二酰辅酶A (20 μM，6分钟) 抑制 MCF-7 细胞 CPT1 活性 (降低 75%)[2]. 丙二酰辅酶A (0-3 μM) 抑制雌性大鼠肝线粒体中的 CPT1 活性[3].
References	[1]. Folmes CD, et L. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc Res. 2007 Jan 15;73(2):278-87. [2]. Thupari JN, et al. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun. 2001 Jul 13;285(2):217-23. [3]. Zammit VA. Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro. Biochem J. 1983 Mar 15;210(3):953-6.

Molecular Formula	C₂₄H₃₈N₇O₁₉P₃S
Molecular Weight	853.58000
Exact Mass	853.11600
PSA	455.66000

Precursor 0
DownStream 10
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2,6-Dioxo-cyclohexancarbaldehyd

2-formyl-1,3-cyclohexanedione

2,6-dioxo-cyclohexanecarbaldehyde

S-(HYDROGEN MALONYL)COENZYME A

3-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-3-oxopropanoicacid

S-(HYDROGEN MALONYL)COENZYME A

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Malonyl CoA

Use of Malonyl CoA

Names

Malonyl CoA Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.