306-52-5

• 常用中文名：磷酸三氯乙酯
• 常用英文名：triclofos
• CAS号：306-52-5
• 分子式：C₂H₄Cl₃O₄P
• 分子量：229.38400
• 相关类别： 有机原料 无机酸酯
• 发布时间：2018-05-14 08:00:00
• 更新时间：2024-01-13 15:09:00
• 三氯磷是一种有效的口服镇静药。三氯磷在体内迅速水解为三氯乙醇(TCEOH)和磷酸单钠,有助于镇静[1]。

名称

• 中文名: 磷酸三氯乙酯
• 英文名: 2,2,2-trichloroethyl dihydrogen phosphate
• 中文别名: 三氯福司
• 英文别名: Triclofosum [INN-Latin]; phosphoric acid mono-(2,2,2-trichloro-ethyl) ester; O-2,2,2-trichloroethyl monophosphate; 2,2,2-trichloroethylphosphate; 2,2,2-trichloroethyl dihydrogenphosphate; Trichloroethyl phosphate; Triclofos [INN:BAN]; Tricloryl; Trichlophos; Trichloryl; Triclofoso [DCIT]; triclofos; Triclos

物化性质

• 密度: 1.891 g/cm3
• 沸点: 321.2ºC at 760 mmHg
• 分子式: C₂H₄Cl₃O₄P
• 分子量: 229.38400
• 闪点: 148.1ºC
• 精确质量: 227.89100
• PSA: 76.57000
• LogP: 1.46590
• 折射率: 1.53
• 储存条件: -20°C

生物活性

• 描述: 三氯磷是一种有效的口服镇静药。三氯磷在体内迅速水解为三氯乙醇(TCEOH)和磷酸单钠,有助于镇静[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体外研究: 三氯磷(0.5-75µg/mL；混合血浆)快速水解为TCEOH和磷酸单钠。三氯酚、三氯乙酸(TCA)、三氯乙醇(TCEOH)和水合氯醛(CH)基质效应的平均%RSD分别为13.9%、5.6%、8.9%和14.9%[1]。
• 参考文献:

  [1]. Sato H, et, al. Simple method to detect triclofos and its metabolites in plasma of children by combined use of liquid chromatography tandem-mass spectrometry and gas chromatography-mass spectrometry. Sci Rep. 2019 Jun 26;9(1):9294.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KM4400000 CHEMICAL NAME : Ethanol, 2,2,2-trichloro-, dihydrogen phosphate CAS REGISTRY NUMBER : 306-52-5 LAST UPDATED : 199803 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C2-H4-Cl3-O4-P MOLECULAR WEIGHT : 229.38 WISWESSER LINE NOTATION : QPQO&O1XGGG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 850 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(11),101,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 850 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(11),101,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1013 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - tetany Lungs, Thorax, or Respiration - cyanosis REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 54(9),77,1989 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20230 mg/kg/17W-I TOXIC EFFECTS : Spinal Cord - other degenerative changes Related to Chronic Data - death REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(11),101,1968 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2835 mg/kg/45D-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - lipids including transport REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 54(9),77,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20230 mg/kg/17W-I TOXIC EFFECTS : Spinal Cord - other degenerative changes Related to Chronic Data - death REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(11),101,1968 ** REPRODUCTIVE DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation DOSE : 500 ug/m3/24H SEX/DURATION : male 17 week(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(6),20,1981 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation DOSE : 500 ug/m3/24H SEX/DURATION : male 17 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(6),20,1981

安全

• 海关编码: 2919900090

合成路线

115-20-8 ~% 306-52-5

文献：Razkin, Jesus; Nilsson, Helena; Baltzer, Lars Journal of the American Chemical Society, 2007 , vol. 129, # 47 p. 14752 - 14758

29175-89-1 ~% 306-52-5

文献：Khwaja,T.A. et al. Journal of the Chemical Society [Section] C: Organic, 1970 , p. 2092 - 2100

115-20-8 10026-13-8 ~% 306-52-5

文献：Delacre Bulletin de la Societe Chimique de France, 1887 , vol. <2>48, p. 785

115-20-8 7719-12-2 ~% 306-52-5

文献：Delacre Bulletin de la Societe Chimique de France, 1887 , vol. <2>48, p. 785

67154-52-3 ~% 306-52-5

文献：Thuong,N.T.; Chabrier,P. Bulletin de la Societe Chimique de France, 1975 , p. 2083 - 2088

上下游产品

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115-20-8 67154-52-3 10026-13-8 7719-12-2
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海关

海关编码	2919900090
中文概述	HS:2919900090 其他磷酸酯及其盐（包括乳磷酸盐）（包括它们的卤化，磺化，硝化和亚硝化衍生物） 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	2919900090 other phosphoric esters and their salts, including lactophosphates; their halogenated, sulphonated, nitrated or nitrosated derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%