triclofos

Modify Date: 2025-08-25 13:13:22

triclofos structure	Common Name	triclofos
	CAS Number	306-52-5	Molecular Weight	229.38400
	Density	1.891 g/cm3	Boiling Point	321.2ºC at 760 mmHg
	Molecular Formula	C₂H₄Cl₃O₄P	Melting Point	N/A
	MSDS	N/A	Flash Point	148.1ºC

Use of triclofos

Triclofos is a potent, orally active sedative. Triclofos is hydrolyzed rapidly into trichloroethanol (TCEOH) and monosodium phosphate in vivo, which contributes to the sedation[1].

Name	2,2,2-trichloroethyl dihydrogen phosphate
Synonym	More Synonyms

Description	Triclofos is a potent, orally active sedative. Triclofos is hydrolyzed rapidly into trichloroethanol (TCEOH) and monosodium phosphate in vivo, which contributes to the sedation[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Triclofos (0.5-75 µg/mL; pooled plasma) is hydrolyzed rapidly into TCEOH and monosodium phosphate. The average %RSD of the matrix effect is 13.9% for triclofos, 5.6% for trichloroacetic acid (TCA), 8.9% for trichloroethanol (TCEOH) and 14.9% for chloral hydrate (CH)[1].
References	[1]. Sato H, et, al. Simple method to detect triclofos and its metabolites in plasma of children by combined use of liquid chromatography tandem-mass spectrometry and gas chromatography-mass spectrometry. Sci Rep. 2019 Jun 26;9(1):9294.

Density	1.891 g/cm3
Boiling Point	321.2ºC at 760 mmHg
Molecular Formula	C₂H₄Cl₃O₄P
Molecular Weight	229.38400
Flash Point	148.1ºC
Exact Mass	227.89100
PSA	76.57000
LogP	1.46590
Index of Refraction	1.53
InChIKey	YYQRGCZGSFRBAM-UHFFFAOYSA-N
SMILES	O=P(O)(O)OCC(Cl)(Cl)Cl
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM4400000

CHEMICAL NAME :: Ethanol, 2,2,2-trichloro-, dihydrogen phosphate

CAS REGISTRY NUMBER :: 306-52-5

LAST UPDATED :: 199803

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C2-H4-Cl3-O4-P

MOLECULAR WEIGHT :: 229.38

WISWESSER LINE NOTATION :: QPQO&O1XGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(11),101,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(11),101,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1013 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - tetany Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 54(9),77,1989 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20230 mg/kg/17W-I

TOXIC EFFECTS :: Spinal Cord - other degenerative changes Related to Chronic Data - death

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(11),101,1968

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2835 mg/kg/45D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 54(9),77,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20230 mg/kg/17W-I

TOXIC EFFECTS :: Spinal Cord - other degenerative changes Related to Chronic Data - death

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 33(11),101,1968 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 500 ug/m3/24H

SEX/DURATION :: male 17 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(6),20,1981

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 500 ug/m3/24H

SEX/DURATION :: male 17 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(6),20,1981

HS Code	2919900090

Ethapon

CAS#:115-20-8

triclofos

CAS#:306-52-5

Literature: Razkin, Jesus; Nilsson, Helena; Baltzer, Lars Journal of the American Chemical Society, 2007 , vol. 129, # 47 p. 14752 - 14758

N/A

CAS#:29175-89-1

triclofos

CAS#:306-52-5

Literature: Khwaja,T.A. et al. Journal of the Chemical Society [Section] C: Organic, 1970 , p. 2092 - 2100

Ethapon

CAS#:115-20-8

Phosphorus pent...

CAS#:10026-13-8

triclofos

CAS#:306-52-5

Literature: Delacre Bulletin de la Societe Chimique de France, 1887 , vol. <2>48, p. 785

Ethapon

CAS#:115-20-8

Phosphorus tric...

CAS#:7719-12-2

triclofos

CAS#:306-52-5

Literature: Delacre Bulletin de la Societe Chimique de France, 1887 , vol. <2>48, p. 785

2-(2,2,2-trichl...

CAS#:67154-52-3

triclofos

CAS#:306-52-5

Literature: Thuong,N.T.; Chabrier,P. Bulletin de la Societe Chimique de France, 1975 , p. 2083 - 2088

Precursor 4
CAS#:115-20-8 Ethapon CAS#:67154-52-3 2-(2,2,2-trichl... CAS#:10026-13-8 Phosphorus pent... CAS#:7719-12-2 Phosphorus tric...
DownStream 0

HS Code	2919900090
Summary	2919900090 other phosphoric esters and their salts, including lactophosphates; their halogenated, sulphonated, nitrated or nitrosated derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Triclofosum [INN-Latin]

phosphoric acid mono-(2,2,2-trichloro-ethyl) ester

O-2,2,2-trichloroethyl monophosphate

2,2,2-trichloroethylphosphate

2,2,2-trichloroethyl dihydrogenphosphate

Trichloroethyl phosphate

Triclofos [INN:BAN]

Tricloryl

Trichlophos

Trichloryl

Triclofoso [DCIT]

triclofos

Triclos

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