159877-47-1

• 常用中文名：(r)-n-boc-3-氨基丁酸甲酯
• 常用英文名：(R)-Methyl 3-((tert-butoxycarbonyl)amino)butanoate
• CAS号：159877-47-1
• 分子式：C₁₀H₁₉NO₄
• 分子量：217.262
• 发布时间：2019-01-01 12:27:51
• 更新时间：2026-07-02 08:26:28

名称

• 中文名: (r)-n-boc-3-氨基丁酸甲酯
• 英文名: methyl (3R)-3-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate
• 中文别名: BOC-R-3-氨基丁酸甲酯盐酸盐; (R)-3-(BOC-氨基)丁酸甲酯; BOC-R-3-氨基丁酸甲酯; (R)-N-BOC-3-氨基丁酸甲酯; (R)-3-((叔丁氧基羰基)氨基)丁酸甲酯
• 英文别名: methyl (3R)-3-[(2-methylpropan-2-yl)oxycbonylamino]butanoate; Methyl (3R)-3-[[(1,1-dimethylethoxy)carbonyl]amino]butanoate; Boc-(R)-3-AMINO-BUTYRIC ACID METHYL ESTER; Butanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]amino]-, Methyl ester, (R); (R)-3-[[(1,1-DiMethylethoxy)carbonyl]amino]butanoic acid Methyl ester; (R)-3-TERT-BUTOXYCARBONYLAMINO-BUTYRIC ACID METHYL ESTER; Butanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]amino]-, Methyl ester, (3R); methyl 3-(R)-[N-(tert-butoxycbonyl)amino]-propanoate; Methyl (R)-N-Boc-3-aminobutyrate; (R)-N-BOC-3-Aminobutyric acid ethyl ester; Methyl (R)-3-(Boc-amino)butanoate; Methyl (R)-3-((tert-butoxycbonyl)amino)butanoate; (R)-Methyl 3-((tert-butoxycbonyl)amino)butanoate; (R)-3-tert-Butoxycbonylamino-butyric acid methyl ester; Methyl (3R)-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)butanoate; methyl(R)-3-(Boc-amino)butanoate; methyl (R)-3-(tert-butoxycarbonylamino)butanoate; (R)-methyl 3-(tert-butoxycarbonyl)butanoate; Butanoic acid,3-[[(1,1-dimethylethoxy)carbonyl]amino]-,methyl ester,(3R); methyl 3-(R)-[N-(tert-butoxycarbonyl)amino]-propanoate; (R)-4-tert-Butoxycbonylamino-butyric acid methyl ester

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 302.8±25.0 °C at 760 mmHg
• 分子式: C₁₀H₁₉NO₄
• 分子量: 217.262
• 闪点: 136.9±23.2 °C
• 精确质量: 217.131409
• PSA: 64.63000
• LogP: 1.73
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.441
• 储存条件: 2-8°C，干燥密封

合成路线

24424-99-5 21731-17-9 ~83% 159877-47-1

文献：Hansen, Karl B.; Rosner, Thorsten; Kubryk, Michele; Dormer, Peter G.; Armstrong III, Joseph D. Organic Letters, 2005 , vol. 7, # 22 p. 4935 - 4938

136703-60-1 ~99% 159877-47-1

文献：Santella III, Joseph B.; Gardner, Daniel S.; Yao, Wenqing; Shi, Chongsheng; Reddy, Prabhakar; Tebben, Andrew J.; DeLucca, George V.; Wacker, Dean A.; Watson, Paul S.; Welch, Patricia K.; Wadman, Eric A.; Davies, Paul; Solomon, Kimberly A.; Graden, Dani M.; Yeleswaram, Swamy; Mandlekar, Sandhya; Kariv, Ilona; Decicco, Carl P.; Ko, Soo S.; Carter, Percy H.; Duncia, John V. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 576 - 585

24424-99-5 139243-54-2 ~94% 159877-47-1

文献：Fisher, Liesl G.; Sher, Philip M.; Skwish, Stephen; Michel, Inge M.; Seiler, Steven M.; Dickinson, Kenneth E. J. Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2253 - 2258

105-45-3 ~% 159877-47-1

文献：Heller, Detlef; Holz, Jens; Komarov, Igor; Drexler, Hans-Joachim; You, Jingsong; Drauz, Karheinz; Boerner, Armin Tetrahedron Asymmetry, 2002 , vol. 13, # 24 p. 2735 - 2741

24424-99-5 6078-06-4 ~% 159877-47-1

文献：Chakraborty, Tushar K.; Ghosh, Animesh Synlett, 2002 , # 12 p. 2039 - 2040

4248-19-5 ~% 159877-47-1

文献：Heller, Detlef; Holz, Jens; Komarov, Igor; Drexler, Hans-Joachim; You, Jingsong; Drauz, Karheinz; Boerner, Armin Tetrahedron Asymmetry, 2002 , vol. 13, # 24 p. 2735 - 2741

64838-60-4 ~% 159877-47-1

文献：Sone, Hiroki; Nemoto, Takayuki; Ishiwata, Hiroyuki; Ojika, Makoto; Yamada, Kiyoyuki Tetrahedron Letters, 1993 , vol. 34, # 52 p. 8449 - 8452

3744-87-4 ~% 159877-47-1

文献：Czekaj, Mark; Klein, Scott I.; Guertin, Kevin R.; Gardner, Charles J.; Zulli, Allison L.; Pauls, Henry W.; Spada, Alfred P.; Cheney, Daniel L.; Brown, Karen D.; Colussi, Dennis J.; Chu, Valeria; Leadley, Robert J.; Dunwiddie, Christopher T. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 12 p. 1667 - 1670

67-56-1 186521-98-2 ~% 159877-47-1

文献：Czekaj, Mark; Klein, Scott I.; Guertin, Kevin R.; Gardner, Charles J.; Zulli, Allison L.; Pauls, Henry W.; Spada, Alfred P.; Cheney, Daniel L.; Brown, Karen D.; Colussi, Dennis J.; Chu, Valeria; Leadley, Robert J.; Dunwiddie, Christopher T. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 12 p. 1667 - 1670

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