146553-06-2

• 常用中文名：(R)-叔丁基(1-(甲氧基(甲基)氨基)-1-氧代丙-2-基)氨基甲酸酯
• 常用英文名：(R)-TERT-BUTYL1-(METHOXY(METHYL)AMINO)-1-OXOPROPAN-2-YLCARBAMATE
• CAS号：146553-06-2
• 分子式：C₁₀H₂₀N₂O₄
• 分子量：232.277
• 发布时间：2018-12-23 11:49:12
• 更新时间：2026-07-05 11:06:06

名称

• 中文名: (R)-1-(甲氧基(甲基)氨基)-1-氧代-2-丙基氨基甲酸叔丁酯
• 英文名: (R)-tert-Butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate
• 中文别名: 叔-丁基N-[(1R)-2-(甲氧基-甲基-氨基)-1-甲基-2-氧代-乙基]氨基甲酸酯; 间羟胺杂质43; 杜韦利西布杂质1; N-(叔丁氧基羰基)-D-丙氨酸-N′-甲氧基-N′-甲酰胺
• 英文别名: (R)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate; N-Boc-D-alanine N'-Methoxy-N'-MethylaMide; (tert-butoxycbonyl)-N-methoxy-N-methyl-D-alaninamide; Cbamic acid, [2-(methoxymethylamino)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester, (R); BENZYL (2-OXO-2-PHENYLETHYL)CBAMATE; Metaminol Impurity 43; Carbamic acid, N-[(1R)-2-(methoxymethylamino)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester; N-Methoxy-N-methyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-alaninamide; Duvelisib Impurity 1; D-Alanine-N'-Methoxy-N'-Methylamide; CbaMic acid, N-[(1R)-2-(MethoxyMethylaMino)-1-Methyl-2-oxoethyl]-, 1,1-diMethylethyl ester; (R)-tert-butyl 1-(Methoxy(Methyl)amino)-1-oxopropan-2-ylcbaMat; (R)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcbamate; tert-butyl (R)-(1-(methoxy(methyl)amino)-1-oxopropan-2-yl)cbamate; (R)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)cbamate; tert-butyl N-[(2R)-1-[methoxy(methyl)amino]-1-oxopropan-2-yl]carbamate

物化性质

• 密度: 1.1±0.1 g/cm3
• 分子式: C₁₀H₂₀N₂O₄
• 分子量: 232.277
• 精确质量: 232.142303
• PSA: 55.40000
• LogP: 1.07
• 外观性状: 白色至灰白色固体
• 折射率: 1.457
• 储存条件: 2-8°C， 密封， 干燥

安全

• 危害码 (欧洲): Xn
• 海关编码: 2924199090

合成路线

15761-38-3 6638-79-5 ~97% 146553-06-2

文献：Valverde, Ibai E.; Bauman, Andreas; Kluba, Christiane A.; Vomstein, Sandra; Walter, Martin A.; Mindt, Thomas L. Angewandte Chemie - International Edition, 2013 , vol. 52, # 34 p. 8957 - 8960 Angew. Chem., 2013 , vol. 125, # 34 p. 9126 - 9129,4

15761-38-3 1117-97-1 ~94% 146553-06-2

文献：Zhou, Zheng Hong; Tang, Yi Long; Li, Kang Ying; Liu, Bing; Tang, Chu Chi Heteroatom Chemistry, 2003 , vol. 14, # 7 p. 603 - 606

3744-87-4 1117-97-1 ~% 146553-06-2 146553-06-2

文献：Tyrrell, Elizabeth; Brawn, Peter; Carew, Mark; Greenwood, Iain Tetrahedron Letters, 2011 , vol. 52, # 3 p. 369 - 372

15761-38-3 ~% 146553-06-2

文献：White, Jonathan M.; Tunoori, Ashok Rao; Turunen, Brandon J.; Georg, Gunda I. Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2573 - 2576

54430-64-7 6638-79-5 ~% 146553-06-2

文献：Patel, Bhavesh H.; Mason, Andrew M.; Patel, Hetal; Coombes, R. Charles; Ali, Simak; Barrett, Anthony G. M. Journal of Organic Chemistry, 2011 , vol. 76, # 15 p. 6209 - 6217

133039-96-0 1117-97-1 ~% 146553-06-2

文献：White, Jonathan M.; Tunoori, Ashok Rao; Turunen, Brandon J.; Georg, Gunda I. Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2573 - 2576

24424-99-5 ~% 146553-06-2

文献：Lucet, Denis; Le Gall, Thierry; Mioskowski, Charles; Ploux, Olivier; Marquet, Andree Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 985 - 988

上下游产品

上游产品  7
15761-38-3 6638-79-5 1117-97-1 3744-87-4
54430-64-7 133039-96-0 24424-99-5
下游产品  4
142723-69-1 79069-50-4 82353-56-8 79821-73-1

海关

海关编码	2924199090
中文概述	2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%