CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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SZ1750000
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CHEMICAL NAME :
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Phosphine oxide, tris(1-aziridinyl)-
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CAS REGISTRY NUMBER :
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545-55-1
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BEILSTEIN REFERENCE NO. :
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0145971
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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68
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MOLECULAR FORMULA :
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C6-H12-N3-O-P
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MOLECULAR WEIGHT :
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173.18
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WISWESSER LINE NOTATION :
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T3NTJ APO&- AT3NTJ&- AT3NTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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37 mg/kg
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TOXIC EFFECTS :
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Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Lungs, Thorax, or Respiration - dyspnea
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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87 mg/kg
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TOXIC EFFECTS :
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Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Lungs, Thorax, or Respiration - dyspnea
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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8800 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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420 mg/kg
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TOXIC EFFECTS :
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Behavioral - muscle weakness
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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25500 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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178 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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430 ug/kg
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TOXIC EFFECTS :
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Gastrointestinal - other changes Blood - leukopenia Blood - other changes
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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870 ug/kg
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TOXIC EFFECTS :
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Gastrointestinal - other changes Blood - leukopenia Blood - other changes
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Bird - chicken
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DOSE/DURATION :
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151 mg/kg
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Bird - quail
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DOSE/DURATION :
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237 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - domestic
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DOSE/DURATION :
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50 mg/kg
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TOXIC EFFECTS :
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Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis Liver - hepatitis (hepatocellular necrosis), diffuse
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Mammal - species unspecified
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DOSE/DURATION :
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15 mg/kg
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TOXIC EFFECTS :
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Tumorigenic - active as anti-cancer agent
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1300 ug/kg/1Y-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - testicular tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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3120 ug/kg/1Y-I
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - testicular tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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5 mg/kg
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SEX/DURATION :
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female 11 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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7500 mg/kg
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SEX/DURATION :
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female 11 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intratesticular
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DOSE :
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2 mg/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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2500 ug/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - germ cell effects (in offspring) Reproductive - Effects on Newborn - delayed effects
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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10 mg/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - other effects on male
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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10 mg/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - other measures of fertility
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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312 ug/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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2500 ug/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intratesticular
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DOSE :
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4 mg/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
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TYPE OF TEST :
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Specific locus test
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TYPE OF TEST :
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Sex chromosome loss and nondisjunction
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TYPE OF TEST :
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Sex chromosome loss and nondisjunction
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TYPE OF TEST :
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Dominant lethal test
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TYPE OF TEST :
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Dominant lethal test
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TYPE OF TEST :
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Heritable translocation test
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TYPE OF TEST :
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Heritable translocation test
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TYPE OF TEST :
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Specific locus test
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TYPE OF TEST :
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Cytogenetic analysis
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TYPE OF TEST :
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Cytogenetic analysis
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TYPE OF TEST :
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Dominant lethal test
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TYPE OF TEST :
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Dominant lethal test
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TYPE OF TEST :
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Dominant lethal test
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TYPE OF TEST :
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Dominant lethal test
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TYPE OF TEST :
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Sperm Morphology
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TYPE OF TEST :
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Cytogenetic analysis
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TYPE OF TEST :
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Cytogenetic analysis
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TYPE OF TEST :
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Dominant lethal test
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TYPE OF TEST :
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Sperm Morphology
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TYPE OF TEST :
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Heritable translocation test
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TYPE OF TEST :
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Cytogenetic analysis
MUTATION DATA
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TYPE OF TEST :
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Sister chromatid exchange
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TEST SYSTEM :
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Rodent - hamster Cells - not otherwise specified
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DOSE/DURATION :
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1400 nmol/L
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REFERENCE :
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SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 18,210,1982 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,75,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,75,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW JORCAI Journal of Organometallic Chemistry. (Elsevier Sequoia SA, POB 851, CH-1001 Lausanne l, Switzerland) V.1- 1963- Volume(issue)/page/year: 76,265,1974 TOXICOLOGY REVIEW JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 172,1765,1960
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