CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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QD1925000
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CAS REGISTRY NUMBER :
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125-72-4
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LAST UPDATED :
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199504
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DATA ITEMS CITED :
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14
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MOLECULAR FORMULA :
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C17-H23-N-O.C4-H6-O6
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MOLECULAR WEIGHT :
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407.51
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WISWESSER LINE NOTATION :
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T6 G666/FQ 2AF Q FX ONT&TTJ IQ O -L &622 QVYQYQVQ &621
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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46 mg/kg
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TOXIC EFFECTS :
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Behavioral - analgesia
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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150 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - rigidity (including catalepsy) Kidney, Ureter, Bladder - urine volume increased
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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48 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - rigidity (including catalepsy)
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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110 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - rigidity (including catalepsy) Kidney, Ureter, Bladder - urine volume increased
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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27 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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285 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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92 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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187 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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32 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Parenteral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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14723 ug/kg
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TOXIC EFFECTS :
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Behavioral - analgesia
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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20 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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25 mg/kg
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SEX/DURATION :
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female 9 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
MUTATION DATA
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TEST SYSTEM :
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Rodent - rat
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DOSE/DURATION :
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2500 ug/kg
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REFERENCE :
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RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 3,105,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6071 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 4165 (estimated) No. of Female Employees: 3802 (estimated)
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