483-57-8

• 常用中文名：Fervenulin
• 常用英文名：fervenulin
• CAS号：483-57-8
• 分子式：C₇H₇N₅O₂
• 分子量：193.16300
• 相关类别： 研究领域 感染
• 发布时间：2016-09-09 01:44:30
• 更新时间：2024-01-10 16:59:09
• Fervenulin 从杀线虫放线菌链霉菌属菌 CMU-MH021 中分离的,具有杀线虫 (nematicidal) 活性,抑制线虫的卵孵化和 J2 的校正死亡率,MIC 分别为 30 μg/mL 和 120 μg/mL。

名称

• 英文名: fervenulin
• 英文别名: 6,8-Dimethyl-8H-pyrimido[5,4-e][1,2,4]triazin-5,7-dion; 6.8-Dimethyl-5.7-dioxo-5.6.7.8-tetrahydro-pyrimido<5.4-e>-as-triazin; Fervenuline; 6,8-dimethyl-8H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione; Kc 1017; Compound 7215; U-7118; Planomycin; Pulanomycin; Phervenulin

物化性质

• 密度: 1.474g/cm3
• 沸点: 417.2ºC at 760 mmHg
• 分子式: C₇H₇N₅O₂
• 分子量: 193.16300
• 闪点: 206.1ºC
• 精确质量: 193.06000
• PSA: 82.67000
• 蒸汽压: 3.61E-07mmHg at 25°C
• 折射率: 1.601

生物活性

• 描述: Fervenulin 从杀线虫放线菌链霉菌属菌 CMU-MH021 中分离的,具有杀线虫 (nematicidal) 活性,抑制线虫的卵孵化和 J2 的校正死亡率,MIC 分别为 30 μg/mL 和 120 μg/mL。
• 相关类别:
  研究领域 >> 感染
• 靶点:

  Nematicidal[1]

• 体外研究: 阿魏蛋白具有广泛的生物学活性,如体外抗菌、抗真菌、抗寄生虫和抗肿瘤等。在250μg/mL浓度下孵育96h后,阿魏素对隐翅虫二期线虫幼体的杀灭率可达100%。
• 参考文献:

  [1]. Ruanpanun P, et al. Nematicidal activity of Fervenulin isolated from a nematicidal actinomycete, Streptomyces sp. CMU-MH021, on Meloidogyne incognita. World J Microbiol Biotechnol. 2011 Jun;27(6):1373-80.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UW7900000 CHEMICAL NAME : Pyrimido(5,4-e)-as-triazine-5,7(6H,8H)-dione, 6,8-dimethyl- CAS REGISTRY NUMBER : 483-57-8 LAST UPDATED : 199603 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C7-H7-N5-O2 MOLECULAR WEIGHT : 193.19 WISWESSER LINE NOTATION : T66 BVNVN GNN JNJ C1 E1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 65 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,220,1959/1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,199,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,518,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 11200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,220,1959/1960

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