361441-95-4

• 常用中文名：(ALPHAS)-ALPHA-[[(1R)-2-羟基-1-苯基乙基]氨基]-金刚烷-1-乙腈
• 常用英文名：1-(S)-adamantan-1-yl-(R)-(2-hydroxy-1-phenylethylamino)acetonitrile
• CAS号：361441-95-4
• 分子式：C₂₀H₂₆N₂O
• 分子量：310.433
• 发布时间：2017-04-14 05:07:49
• 更新时间：2026-07-25 07:55:44

名称

• 中文名: (ALPHAS)-ALPHA-[[(1R)-2-羟基-1-苯基乙基]氨基]-金刚烷-1-乙腈
• 英文名: (2S)-2-(1-adamantyl)-2-[[(1R)-2-hydroxy-1-phenylethyl]amino]acetonitrile
• 中文别名: (S)-2-(金刚烷-1-基)-2-[[(R)-2-羟基-1-苯基乙基]氨基]乙腈; (S)-2-(((3S,5S,7S)-金刚烷-1-基)-2-(((R)-2-羟基-1-苯乙基)氨基)乙腈(沙格列汀杂质); 沙沙利汀杂质24
• 英文别名: (2S)-2-(Adamantan-1-yl)-2-(((R)-2-hydroxy-1-phenylethyl)amino)acetonitrile; TRI015; Tricyclo[3.3.1.13,7]decane-1-acetonitrile, .alpha.- [[(1R)-2-hydroxy-1-phenylethyl]amino]-, (.alpha.S); (S)-2-((3S,5S,7S)-adamantan-1-yl)-2-(((R)-2-hydroxy-1-phenylethyl)amino)acetonitrile; 2-(S)-adamantan-1-yl-(R)-(2-hydroxy-1-phenylethylamino)acetonitrile; Tricyclo[3.3.1.13,7]decane-1-acetonitrile, α-[[(1R)-2-hydroxy-1-phenylethyl]amino]-, (αS); (S)-2-((3S,5S,7S)-Adamantan-1-yl)-2-(((R)-2-hydroxy-1-phenylethyl)amino)acetonitrile (Saxagliptin Impurity）; (2S)-Adamantan-1-yl{[(1R)-2-hydroxy-1-phenylethyl]amino}acetonitrile; Tricyclo[3.3.1.13,7]decane-1-acetonitrile,.alpha.S); (alphaS)-alpha-[[(1R)-2-Hydroxy-1-phenylethyl]amino]-tricyclo[3.3.1.1(3,7)]decane-1-acetonitrile; (S)-2-(Adamantan-1-yl)-2-[[(R)-2-hydroxy-1-phenylethyl]amino]acetonitrile

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 511.0±35.0 °C at 760 mmHg
• 分子式: C₂₀H₂₆N₂O
• 分子量: 310.433
• 闪点: 262.8±25.9 °C
• 精确质量: 310.204498
• PSA: 56.05000
• LogP: 4.16
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.599

合成路线

2094-74-8 56613-80-0 151-50-8 ~64% 361441-95-4

文献：BRISTOL-MYERS SQUIBB COMPANY Patent: WO2005/12249 A2, 2005 ; Location in patent: Page/Page column 35 ; WO 2005/012249 A2

773837-37-9 2094-74-8 56613-80-0 ~61% 361441-95-4

文献：Dong, Jizhe; Gong, Yanchun; Liu, Jun; Chen, Xiangfeng; Wen, Xiaoan; Sun, Hongbin Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1383 - 1393

770-71-8 ~% 361441-95-4

文献：LEE PHARMA LIMITED; ALLA, Venkat Reddy; ALLA, Raghu Mitra; DUBEY, Ajay Kumar; REDDY, P. Ramakrishna Patent: WO2014/57495 A1, 2014 ;

828-51-3 ~% 361441-95-4

文献：LEE PHARMA LIMITED; ALLA, Venkat Reddy; ALLA, Raghu Mitra; DUBEY, Ajay Kumar; REDDY, P. Ramakrishna Patent: WO2014/57495 A1, 2014 ;

711-01-3 ~% 361441-95-4

文献：LEE PHARMA LIMITED; ALLA, Venkat Reddy; ALLA, Raghu Mitra; DUBEY, Ajay Kumar; REDDY, P. Ramakrishna Patent: WO2014/57495 A1, 2014 ;

上下游产品

上游产品  7
2094-74-8 56613-80-0 151-50-8 773837-37-9
770-71-8 828-51-3 711-01-3
下游产品  4
361441-97-6 361442-00-4 361442-01-5 709031-43-6