208111-36-8

• 常用中文名：(3-氯-4-氟苯基)[4-氟-4-(羟基甲基)-1-哌啶基]甲酮
• 常用英文名：(3-Chloro-4-fluorophenyl)[4-fluoro-4-(hydroxymethyl)-1-piperidinyl]methanone
• CAS号：208111-36-8
• 分子式：C₁₃H₁₄ClF₂NO₂
• 分子量：289.70600
• 发布时间：2018-12-11 15:28:52
• 更新时间：2024-02-05 12:31:54

名称

• 中文名: (3-氯-4-氟苯基)[4-氟-4-(羟基甲基)-1-哌啶基]甲酮
• 英文名: (3-chloro-4-fluorophenyl)-[4-fluoro-4-(hydroxymethyl)piperidin-1-yl]methanone
• 中文别名: N-(3-氯-4-氟苯甲酰基)-4-氟-4-n-(3-氯-4-氟苯甲酰基)-4-氟-4-羟基甲基哌啶
• 英文别名: N-(3-chloro-4-fluorobenzoyl)-4-fluoro-4-hydroxymethylpiperidine; (4-fluoro-4-hydroxymethylpiperidin-1-yl)-(3-chloro-4-fluorophenyl)methanone; (3-Chloro-4-fluorophenyl)[4-fluoro-4-(hydroxymethyl)-1-piperidinyl]methanone

物化性质

• 密度: 1.38
• 沸点: 442.537ºC at 760 mmHg
• 熔点: 188-190ºC
• 分子式: C₁₃H₁₄ClF₂NO₂
• 分子量: 289.70600
• 闪点: 221.439ºC
• 精确质量: 289.06800
• PSA: 40.54000
• LogP: 2.35360

合成路线

208111-51-7 ~48% 208111-36-8

文献：Pierre Fabre Medicament Patent: US6020345 A1, 2000 ; US 6020345 A

177-11-7 ~% 208111-36-8

文献：Vacher, Bernard; Bonnaud, Bernard; Funes, Philippe; Jubault, Nathalie; Koek, Wouter; Assie, Marie-Bernadette; Cosi, Cristina; Kleven, Mark Journal of Medicinal Chemistry, 1999 , vol. 42, # 9 p. 1648 - 1660

65055-17-6 ~% 208111-36-8

文献：Vacher, Bernard; Bonnaud, Bernard; Funes, Philippe; Jubault, Nathalie; Koek, Wouter; Assie, Marie-Bernadette; Cosi, Cristina; Kleven, Mark Journal of Medicinal Chemistry, 1999 , vol. 42, # 9 p. 1648 - 1660

223632-64-2 ~% 208111-36-8

文献：Vacher, Bernard; Bonnaud, Bernard; Funes, Philippe; Jubault, Nathalie; Koek, Wouter; Assie, Marie-Bernadette; Cosi, Cristina; Kleven, Mark Journal of Medicinal Chemistry, 1999 , vol. 42, # 9 p. 1648 - 1660

上下游产品

上游产品  3
177-11-7 65055-17-6 223632-64-2
下游产品  2
208111-39-1 208110-64-9