120205-48-3

• 常用中文名：(3R,4S,5S)-3-甲氧基-5-甲基-4-(甲基氨基)庚酸叔丁酯盐酸盐
• 常用英文名：(3R,4S,5S)-3-Methoxy-5-methyl-4-(methylamino)heptanoic Acid 1,1-Dimethylethyl Ester Hydrochloride
• CAS号：120205-48-3
• 分子式：C₁₄H₃₀ClNO₃
• 分子量：295.846
• 相关类别： 研究领域 癌症
• 发布时间：2018-10-07 20:08:24
• 更新时间：2024-01-04 10:20:58
• Monomethyl auristatin E intermediate-1 是合成 Monomethyl auristatin E (HY-15162) 的中间反应物。Monomethyl auristatin E (MMAE) 是具有抗癌活性的微管蛋白聚合 (Microtubule/Tubulin) 抑制剂。MMAE 被广泛用作抗体-药物偶联物 (ADCs) 的细胞毒性成分 (ADC Cytotoxin)。

名称

• 中文名: (3R,4S,5S)-3-甲氧基-5-甲基-4-(甲基氨基)庚酸叔丁酯盐酸盐
• 英文名: 2-Methyl-2-propanyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino) heptanoate hydrochloride (1:1)
• 英文别名: tert-butyl trans(+-)-4-amino-3-hydroxypiperidine-1-carboxylate; Heptanoic acid, 3-methoxy-5-methyl-4-(methylamino)-, 1,1-dimethylethyl ester, (3R,4S,5S)-, hydrochloride (1:1); (3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol; (3R,4R)-N-tert-butoxycarbonyl-3-hydroxy-4-hydroxymethylpyrrolidine; 2-Methyl-2-propanyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoate hydrochloride (1:1); tert-Butyl (3R,4S,5S)-3-methoxy-4-(N-methylamino)-5-methylheptanoate hydrochloride; (3R,4S,5S)-3-Methoxy-5-methyl-4-(methylamino)heptanoic Acid 1,1-Dimethylethyl Ester Hydrochloride; N-tert-butoxycarbonyl-(3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine; tert-butyl (3R*,4R*)-4-amino-3-hydroxy-piperidine-1-carboxylate; tert-butyl (3R,4S)-3-amino-4-hydroxy-azepan-1-carboxylate; (3R,4R)-1-tert-butoxycarbonyl-3-hydroxy-4-(hydroxymethyl)pyrrolidine; Dil tert-butyl ester hydrochloride; tert-butyl (3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoate hydrochloride; (3R,4R)-tert-butyl 3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate; H-Dil-OtBu.HCl; (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidin-1-N-carboxylic acid tert-butyl ester; (3R,4S,5S)-Dil-OBu-t*HCl; (3R,4S)-3-Amino-4-hydroxy-azepane-1-carboxylic acid tert-butyl ester; tert-butyl (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine-1-carboxylate; (3R,4S,5S)-3-methoxy-5-methyl-4-methylamino-heptanoic acid tert-butyl ester hydrochloride; (3R,4S,5S)-tert-butyl 3-methoxy-5-methyl-4-(methylamino)heptanoatehydrochloride; Diltiazem hydrochloride; (3R,4S,5S)-tert-butyl 3-Methoxy-5-Methyl-4-(MethylaMino)heptanoate hydroc hloride

物化性质

• 分子式: C₁₄H₃₀ClNO₃
• 分子量: 295.846
• 精确质量: 295.191437
• PSA: 47.56000
• LogP: 3.56020
• 储存条件: 室温，保存在惰性气体中

生物活性

• 描述: Monomethyl auristatin E intermediate-1 是合成 Monomethyl auristatin E (HY-15162) 的中间反应物。Monomethyl auristatin E (MMAE) 是具有抗癌活性的微管蛋白聚合 (Microtubule/Tubulin) 抑制剂。MMAE 被广泛用作抗体-药物偶联物 (ADCs) 的细胞毒性成分 (ADC Cytotoxin)。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.