183133-94-0

• 常用中文名：7,10-二甲氧基-10-DAB III
• 常用英文名：7,10-dimethoxy-Baccatin III
• CAS号：183133-94-0
• 分子式：C₃₁H₄₀O₁₀
• 分子量：572.643
• 发布时间：2018-02-27 08:00:00
• 更新时间：2026-07-01 23:49:34

名称

• 中文名: 7β,10β-二甲氧基多西紫杉醇
• 英文名: 7,10-MeO-10-DAB
• 中文别名: 卡巴他赛起始物1杂质A; 7,10二甲氧基 (卡巴他赛中间体); 10二甲氧基; 7,10二甲氧基10-DAB (卡巴他赛中间体); 卡巴他赛杂质12; 卡巴他塞杂质; 7,10-二甲氧基-10-DAB III (卡巴他赛中间体); 卡巴他赛N-1; 卡巴他赛N-1(7Β-10Β-二甲氢基10去乙酰基巴卡亭Ⅲ; 卡巴他赛杂质8; 7,10-二甲氧基-10-DAB II; 7,10二甲氧基10-DAB; 卡巴他赛杂质9; 7Β,10Β-二甲氧基-脱乙酰巴卡亭; 卡巴他赛杂质6; 卡巴他赛杂质7; 双甲基10-DAB; 卡巴他赛杂质5; 卡巴他赛中间体1; 10-去乙酰基-7,10-二甲氧基巴卡亭III; 7Β,10Β-双甲基-10-DAB; 卡巴他赛去酰基杂质; 7,10二甲氧基; (2,4S,4AS,6R,9S,11S,12S,12,12BS)-12B-乙酰氧基-9,11-二羟基-4,6-二甲氧基-4A,8,13,13-四甲基-5-氧代-2A,3,4,4A,5,6,9,10,11,12,12A,12B-十二烷基-1H-7,11-甲氧基环癸[3,4]苯并[1,2-B]氧基苯甲酸酯; (2,4S,4AS,6R,9S,11S,12S,12,12BS)-12B-(乙酰氧基)-12-(苯甲酰氧基)-1,2A,3,4,4A,6,9,10,11,12,12A,12B-十二氢-9,11-二羟基-4,6-二甲氧基-4A,8,13,13-四甲基-7,11-亚甲基-5H-环癸五烯并[3,4]苯并[1,2-B]噁丁-5-酮; 卡巴他赛杂质ZJT1; 卡巴他赛杂质; 7,10-二甲氧基-10-DABIII7; (2,4S,4aS,6R,9S,11S,12S,12,12bS)-4,6-二甲氧基-4a,8,13,13-四甲基-5-氧代-9,11-二羟基-12b-乙酰氧基-2a,3,4,4a,5,6,9,10,11,12,12a,12b-十二氢-1H-7,11-桥亚甲基环癸并[3,4]苯并[1,2-b]氧杂环丁烷-12-基苯甲酸酯; 卡巴他赛杂质(15个); 卡巴他赛中间体; 卡巴他赛杂质16; 卡巴他赛杂质37; 卡巴他赛杂质18; 7Β,10Β-二甲氧基-10-DABⅢ; 卡巴他赛杂质17
• 英文别名: 7β,10β-diMethoxy-10-DAB-II; 7β,10β-dimethoxy-10-DAB-III; (2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-di; 7,10-dimethyl-10-DAB; 183-0 7, 10-Dimethoxy-10-DAB III; 7,10-dimethoxy -10-DAB; Cabazitaxel intermediate; 11-methano-5H-cyclodeca[3; (2,4S,4aS,6R,9S,11S,12S,12,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one; (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,15-dihydroxy-9,12-dimethoxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]htadec-13-en-2-yl] benzoate; 7β,10β-Dimethoxy-10-dabⅢ; (2,4S,4aS,6R,9S,11S,12S,12,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12; (2α,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; Cabazitaxel lmpurities; (2,4S,4aS,6R,9S,11S,12S,12,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-on; 11S; 7,10-Dimethoxy-10-DAB III; 7,10-Dimethoxy-10-DAB III (2,4S,4aS,6R,9S,11S,12S,12,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one; 7β,10β-Dimethyl-10-deacetylbaccatinIII; Cabazitaxel interMediate 1; 7,10-Dimethoxy-10-DABIII; 4,6-Dimethoxy Baccatin III; 13-tetramethyl-7; 12b-dodecahydro-9; 7,10-dimethoxy-Baccatin; 7,10-Dimethoxy-10-DA; 2α,3ξ,5β,7β,10β,13α)-4-Acetoxy-1,13-dihydroxy-7,10-diMethoxy-9-oxo-5,20-oxytax-11-en-2-yl benzoate; (2,4S,4aS,6R,9S,11S,12S,12,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-oneChemicalBook; Cabazitaxel Deacyl Impurity; 12S; 2-b]oxet-5-oneChemicalBook; Cabazitaxel IMP; 7,1-DiMethoxy-1-DAB III; 12a; Cabazitaxel Impurity 17; Cabazitaxel Initiator 1 impurity A; 6-dimethoxy-4a; 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-, (2,4S,4aS,6R,9S,11S,12S,12,12bS); 12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1; (2,4S,4aS,6R,9S,11S,12S,12; (2,4S,4aS,6R,9S,11S,12S,12,12bS)-12b-acetoxy-9,11-dihydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-Methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate; 4-Deacetyl-4-propionyl Cabazitaxel; Cabazitaxel Impurity; 4]benz[1; 10-Dimethoxy-10-DAB III; 7β,10β-diMethoxy-10-deacetylbaccatin III; 10-Deacetyl-7,10-dimethoxy-Baccatin III; 11-dihydroxy-4; (2,4S,4aS,6R,9S,11S,12S,12,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-9,11-dihydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxe; 7,10-dimethylbaccatin III

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 675.8±55.0 °C at 760 mmHg
• 分子式: C₃₁H₄₀O₁₀
• 分子量: 572.643
• 闪点: 213.0±25.0 °C
• 精确质量: 572.262146
• PSA: 137.82000
• LogP: 4.54
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.585
• 储存条件: 2~8 ℃

安全

• 危害码 (欧洲): Xi

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