916210-98-5

• 常用中文名：2-氯-4-氨甲基吡啶盐酸盐
• 常用英文名：(2-Chloropyridin-4-yl)methanamine hydrochloride
• CAS号：916210-98-5
• 分子式：C₆H₈Cl₂N₂
• 分子量：179.047
• 相关类别： 研究领域 心血管疾病
• 发布时间：2018-08-31 03:18:33
• 更新时间：2024-01-02 18:46:25
• LOXL2-IN-1 hydrochloride是选择性的 LOXL2 抑制剂,IC50 值为126 nM。

名称

• 中文名: 2-氯-4-氨甲基吡啶
• 英文名: (2-Chloropyridin-4-yl)methanamine hydrochloride
• 英文别名: (2-chloropyridin-4-yl)methanamine,hydrochloride; 1-(2-Chloro-4-pyridinyl)methanamine hydrochloride (1:1); 4-Pyridinemethanamine, 2-chloro-, hydrochloride (1:1)

物化性质

• 分子式: C₆H₈Cl₂N₂
• 分子量: 179.047
• 精确质量: 178.006454
• PSA: 38.91000
• LogP: 2.69600
• 储存条件: 2-8°C，保存于惰性气体中

生物活性

• 描述: LOXL2-IN-1 hydrochloride是选择性的 LOXL2 抑制剂,IC50 值为126 nM。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
  研究领域 >> 心血管疾病
• 靶点:

  IC50: 126 nM (LOXL2)[1]

• 体外研究: 显示LOXL2-IN-1对LOXL2和LOX以及其他三种胺氧化酶(MAO-A,MAO-B和SSAO)具有选择性。在人全血LOXL2测定中,LOXL2-IN-1的IC50为1.45μM,而不存在血液蛋白时为126nM。与LOX + BSA相比,LOXL2-IN-1对LOXL2 + BSA(IC50 = 190nM)的选择性为31倍(IC50 =5.91μM)。针对一组含有非LTQ的AO酶(MAO-A,MAO-B和SSAO),发现LOXL2-IN-1在30μM时无活性。 LOXL2-IN-1被分析用于抑制三种不同的CYP酶(CYP 3A4,2C9和2D6),并且在每种情况下IC50超过30μM[1]。
• 参考文献:

  [1]. Hutchinson JH, et al. Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX. ACS Med Chem Lett. 2017 Mar 1;8(4):423-427.

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: (2-Chloropyridin-4-yl)methanamine hydrochloride Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:(2-Chloropyridin-4-yl)methanamine hydrochloride CAS number:916210-98-5 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C6H8Cl2N2 Molecular weight:179.0 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 海关编码: 2933399090

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%