58479-68-8

• 常用中文名：桔梗皂苷D
• 常用英文名：Platycodin D
• CAS号：58479-68-8
• 分子式：C₅₇H₉₂O₂₈
• 分子量：1225.324
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-09-25 16:50:07
• 更新时间：2026-07-12 17:15:53
• Platycodin D 是从橘梗中分离得到的皂苷类化合物,为 AMPKα 的激活剂,具有抗肥胖活性。

名称

• 中文名: 桔梗皂苷D
• 英文名: Platycodin D
• 中文别名: (2S,3R,4S,5S)-3-(((2S,3R,4S,5R,6S)-5-(((2S,3R,4S,5R)-4-(((2S,3R,4R)-3,4-二羟基-4-(羟甲基)四氢呋喃-2-基)氧基)-3,5-二羟基四氢-2H-吡喃-2-基)氧基)-3,4-二羟基-6-甲基四氢-2H -吡喃-2-基)氧基)-4,5-二羟基四氢呋喃-2H-吡喃-2-基 (4,5R,6aS,6bR,8,10R,11S,12,12bR,14bS)-5,11-二羟基-9,9-双(羟甲基)-2,2,6a,6b,12a-五甲基-10-(((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基))四氢-2H-吡喃-2-基)氧基)-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-十八氢蒎烯-4a(2H)-羧酸酯; 桔梗皂苷 D, 来源于桔梗; 桔梗皂苷 D; 桔梗皂苷D/HPLC; 桔梗皂苷D(分析标准品); 桔梗皂苷DPLATYCODIN D; 桔梗皂苷D(标准品); (2S,3R,4S,5S)-3-(((2S,3R,4S,5R,6S)-5-(((2S,3R,4S,5R)-4-(((2S,3R,4R)-3,4-二羟基-4-(羟甲基)四氢呋喃-2-基)氧基)-3,5-二羟基四氢-2H-吡喃-2-基)氧基)-3,4-二羟基-6-甲基四氢-2H -吡喃-2-基)氧基)-4,5-二羟基四氢呋喃-2H-吡喃-2-基 (4,5R,6AS,6BR,8,10R,11S,12,12BR,14BS)-5,11-二羟基-9,9-双(羟甲基)-2,2,6A,6B,12A; 桔梗皂苷D(对照品); PLATYCODIN D 桔梗皂苷D; 2-苯硫基乙醇/2-(Phenylthio)ethanol; 桔梗皂苷; 桔梗皂苷 D,10 MM DMSO 溶液
• 英文别名: Platycodin D, 10 mM in DMSO; (4,5R,6aS,6bR,8,10R,11S,12,12bR,14bS)-(2S,3R,4S,5S)-3-(((2S,3R,4S,5R,6S)-5-(((1R,2S,3S,4; TIANFU-CHEM - chaeline hydrochloride; Platycodin D Exclusive; PlatycodinD; Platycodin D from Platycodon andiflorus (Jacq.) A. DC; Platycodin; (2S,3R,4S,5S)-3-(((2S,3R,4S,5R,6S)-5-(((2S,3R,4S,5R)-4-(((2S,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-2-yl (4,5R,6aS,6bR,8,10R,11S,12,12bR,14bS)-5,11-dihydroxy-9,9-bis(hydroxymethyl)-2,2,6a,6b,12a-pentamethyl-10-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-cboxylate; Platycodin D Standd; (2S,3R,4S,5S)-3-(((2S,3R,4S,5R,6S)-5-(((2S,3R,4S,5R)-4-(((2S,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-3,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-2-yl (4,5R,6aS,6bR,8,10R,11S,12,12bR,14bS)-5,11-dihydroxy-9,9-bis(hydroxymethyl)-2,2,6a,6b,12a-pentamethyl-10-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b; Platycodon andiflorum saponins; Olean-12-en-28-oic acid, 3-(β-D-glucopyranosyloxy)-2,16,23,24-tetrahydroxy-, O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-α-L-abinopyranosyl ester, (2β,3β,16α); 3-O-[(2S,3R,4R)-3,4-Dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-β-D-xylopyranosyl-(1->4)-6-deoxy-α-L-mannopyranosyl-(1->2)-1-O-[(2β,3β,16α)-3-(β-D-glucopyranosyloxy)-2,16,23,2 ; 4-tetrahydroxy-28-oxoolean-12-en-28-yl]-α-L-arabinopyranose

物化性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₅₇H₉₂O₂₈
• 分子量: 1225.324
• 精确质量: 1224.577515
• PSA: 453.28000
• LogP: -0.69
• 外观性状: 固体
• 折射率: 1.659
• 储存条件: 2~8°C

生物活性

• 描述: Platycodin D 是从橘梗中分离得到的皂苷类化合物,为 AMPKα 的激活剂,具有抗肥胖活性。
• 相关类别:
  信号通路 >> 表观遗传学 >> AMPK
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AMPK
  研究领域 >> 代谢疾病
• 靶点:

  AMPKα[1]

• 参考文献:

  [1]. Kim HL, et al. Platycodin D, a novel activator of AMP-activated protein kinase, attenuates obesity in db/db mice via regulation of adipogenesis and thermogenesis. Phytomedicine. 2019 Jan;52:254-263.

安全

• 危害码 (欧洲): Xi
• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport
• RTECS号: RK0177962

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