655-05-0

• 常用中文名：托扎啉酮
• 常用英文名：Thozalinone
• CAS号：655-05-0
• 分子式：C₁₁H₁₂N₂O₂
• 分子量：204.23
• 发布时间：2018-09-10 17:09:18
• 更新时间：2024-01-10 18:26:59
• Thozalinone也被称为5-苯基-2-二甲基氨基-2-恶唑啉-4-酮,是一种具有抗四苯那嗪抑郁活性的兴奋剂。Thozalinone具有独特的特性,区别于拟交感神经胺[1]。

名称

• 中文名: 托扎啉酮
• 英文名: 2-(dimethylamino)-5-phenyl-1,3-oxazol-4-one
• 中文别名: 2-(二甲基氨基)-5-苯基-2-恶唑啉-4-酮
• 英文别名: 2-Dimethylamino-5-phenyl-4-oxazolinon-(4); Tozalinona [INN-Spanish]; 2-Oxazolin-4-one,2-(dimethylamino)-5-phenyl; 5-Phenyl-2-dimethylamino-2-oxazolin-4-on; 2-(Dimethylamino)-5-phenyl-2-oxazolin-4-one; 2-Dimethylamino-5-phenyl-4-oxo-2-oxazolin; 2-Dimethylamino-4-oxo-5-phenyl-oxazolin; Tozalinonum [INN-Latin]; Stimsen; 2-dimethylamino-5-phenyl-oxazol-4-one; Tozalinone; THOZALINONE

物化性质

• 密度: 1.19g/cm3
• 沸点: 294.8ºC at 760 mmHg
• 熔点: 134.5ºC
• 分子式: C₁₁H₁₂N₂O₂
• 分子量: 204.23
• 闪点: 132.1ºC
• 精确质量: 204.09000
• PSA: 41.90000
• LogP: 0.63770
• 折射率: 1.584
• 储存条件: 2-8°C

生物活性

• 描述: Thozalinone也被称为5-苯基-2-二甲基氨基-2-恶唑啉-4-酮,是一种具有抗四苯那嗪抑郁活性的兴奋剂。Thozalinone具有独特的特性,区别于拟交感神经胺[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Greenblatt EN, et al. Some pharmacologic properties of thozalinone, a new excitant. Toxicol Appl Pharmacol. 1965 Jul;7(4):566-78.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RQ5775000 CHEMICAL NAME : 2-Oxazolin-4-one, 2-(dimethylamino)-5-phenyl- CAS REGISTRY NUMBER : 655-05-0 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C11-H12-N2-O2 MOLECULAR WEIGHT : 204.25 WISWESSER LINE NOTATION : T5NV DO CHJ CR& EN1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >3000 mg/kg TOXIC EFFECTS : Behavioral - ataxia Behavioral - somnolence (general depressed activity) REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1240 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 570 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965

安全

• 海关编码: 2934999090

合成路线

2152-34-3 124-40-3 ~% 655-05-0

文献：Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1679 - 1685

2152-34-3 77-78-1 ~% 655-05-0

文献：Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1686 - 1691

19331-89-6 124-40-3 ~% 655-05-0

文献：Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1679 - 1685

100-52-7 ~% 655-05-0

文献：Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1679 - 1685

1467-79-4 774-40-3 ~% 655-05-0

文献：Howell,C.F. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 1679 - 1685

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%