2450-53-5

• 常用中文名：异绿原酸A
• 常用英文名：Isochlorogenic acid A
• CAS号：2450-53-5
• 分子式：C₂₅H₂₄O₁₂
• 分子量：516.451
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-07-17 17:18:51
• 更新时间：2026-06-30 19:52:54
• 3,5-Dicaffeoylquinic acid是一种具有抗氧化和抗炎活性的天然酚酸。

名称

• 中文名: 异绿原酸A
• 英文名: Isochlorogenic acid A
• 中文别名: 3,5-二咖啡酰奎宁酸/两个CAS; 抑制剂3,5-Di-O-caffeoylquinic acid; 异绿原酸A(标准品); 3,5-O-二咖啡酰奎宁酸; 甲醇中异绿原酸A; 异绿原酸A(3,5-O-二咖啡酰奎宁酸)标准品; 3,5-二咖啡酰奎尼酸; (1R,3R,4S,5R)-3,5-双(((E)-3-(3,4-二羟基苯基)丙烯酰)氧基)-1,4-二羟基-3-甲基环己烷甲酸; 异绿原酸A(对照品); 异绿原酸A(3,5-二咖啡酰奎宁酸); (1R,3R,4S,5R)-3,5-双((3-(3,4-二羟基苯基)丙烯酰)氧基)-1,4-二羟基-3-甲基环己烷甲酸; 异绿原酸A(3,5-O-二咖啡酰奎宁酸); ISOCHLOROGENIC ACID A 异绿原酸A; 3,5-二咖啡酰奎宁酸; Isochlorogenic acid A 异绿原酸A 标准品 Isochlorogenic acid A; ISOCHLOROGENIC ACID A 异绿原酸A 标准品; 异氯原酸A/异绿原酸A; 异绿原酸 A; 异绿原酸 A, 来源于金银花; 3,5-二咖啡酰奎宁酸(异绿原酸 A); 异绿源酸A; 异绿原酸 A,10 MM DMSO 溶液
• 英文别名: Quinic acid 3,5-di-O-caffeate; 1β,4β-Dihydroxy-3β,5α-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1α-cyclohexanecboxylic acid; 3,5-di-O-caffeoyl quinic acid; 3α,5β-Bis[[1-oxo-3-(3,4-dihydroxyphenyl)-2-propenyl]oxy]-1α,4α-dihydroxycyclohexane-1-cboxylic acid; 3,5-Dicaffeylquinic acid; CJ 4-16-4; 3,5-di-O-trans-caffeoyl-D-quinic acid; Isochlorogenic acid A，3,5-Dicaffeoylquinic acid; Isochlorogenic acid A from Lonicera japonica Thunb; (3R,5R)-3,5-Bis{[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]oxy}-1,4-dihydroxycyclohexanecarboxylic acid; Isochlorogenic acid A, froM Lonicera japonica; Isochlorogenic acid A, 10 mM in DMSO; 3',5'-Isochlorogenic acid A; CJ -4; 1β,4β-Dihydroxy-3β,5α-bis[3-(3,4-dihydroxyphenyl)propenoyloxy]cyclohexanecboxylic acid; 1α,4α-Dihydroxy-3β,5α-bis[3-(3,4-dihydroxyphenyl)propenoyloxy]cyclohexanecboxylic acid; Cyclohexanecboxylic acid, 3,5-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,4-dihydroxy-, (1α,3R,4α,5R); 3β,5α-Bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1β,4β-dihydroxycyclohexanecboxylic acid; Dicaffeoylquinic acid; (3R,5R)-3,5-Bis{[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoyl]oxy}-1,4-dihydroxycyclohexanecboxylic acid; 3,5-Dicaffeoylquinic acid-RM; 3,5-dicaffeoylepi-quinic acid; ISOCHLOROGENIC ACID A(SH); Isochlorogenic acid A from Lonicera japonica; 3,5-Di-caffeoylquinic acid; 3,5-di-O-caffeoylquinic acid; IsochlorogenicacidA; 3,5-Dicaffeoylquinic acid; 1β,4β-Dihydroxy-3β,5α-bis[3-(3,4-dihydroxyphenyl)acryloyloxy]cyclohexane-1-cboxylic acid; (1R,3R,4S,5R)-3,5-Bis((3-(3,4-dihydroxyphenyl)acryloyl)oxy)-1,4-dihydroxy-3-methylcyclohexane-1-cboxylic acid; 3,5-CQA; 3,5-Di-O-caffeoylquinic acid，Isochlorogenic acid A; Isochlorogenic acid A in Methanol; (3R,5R)-3,5-Bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4-dihydroxycyclohexanecarboxylic acid; Isochloric acid A

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 826.2±65.0 °C at 760 mmHg
• 熔点: 170-172ºC
• 分子式: C₂₅H₂₄O₁₂
• 分子量: 516.451
• 闪点: 280.4±27.8 °C
• 精确质量: 516.126770
• PSA: 211.28000
• LogP: 1.05
• 外观性状: 灰色至黄色结晶固体
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.719
• 储存条件: ?20°C

生物活性

• 描述: 3,5-Dicaffeoylquinic acid是一种具有抗氧化和抗炎活性的天然酚酸。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 苯丙酸类
  研究领域 >> 其他
• 参考文献:

  [1]. Zhang YH, et al. 3,5-Dicaffeoylquinic acid isolated from Artemisia argyi and its ester derivatives exert anti-leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects. Fitoterapia. 2012 Oct;83(7):1281-5.

  [2]. Malarz J, et al. Long-term cultured hairy roots of chicory-a rich source of hydroxycinnamates and 8-deoxylactucin glucoside. Appl Biochem Biotechnol. 2013 Dec;171(7):1589-601.

  [3]. Wan C, et al. Isolation and identification of phenolic compounds from Gynura divaricata leaves. Pharmacogn Mag. 2011 Apr;7(26):101-8.

安全

• 危害码 (欧洲): Xi
• 安全声明 (欧洲): 24/25
• 危险品运输编码: NONH for all modes of transport

合成路线

1352319-04-0 139-85-5 ~68% 2450-53-5

文献：Raheem, K. Saki; Botting, Nigel P.; Williamson, Gary; Barron, Denis Tetrahedron Letters, 2011 , vol. 52, # 52 p. 7175 - 7177

1352319-06-2 ~% 2450-53-5

文献：Tetrahedron Letters, , vol. 52, # 52 p. 7175 - 7177

1352319-09-5 ~% 2450-53-5

文献：Tetrahedron Letters, , vol. 52, # 52 p. 7175 - 7177

1352319-07-3 ~% 2450-53-5

文献：Tetrahedron Letters, , vol. 52, # 52 p. 7175 - 7177

1352319-08-4 ~% 2450-53-5

文献：Tetrahedron Letters, , vol. 52, # 52 p. 7175 - 7177

1352319-05-1 ~% 2450-53-5

文献：Tetrahedron Letters, , vol. 52, # 52 p. 7175 - 7177

77-95-2 ~% 2450-53-5

文献：Tetrahedron Letters, , vol. 52, # 52 p. 7175 - 7177

163217-18-3 ~% 2450-53-5

文献：Tetrahedron Letters, , vol. 52, # 52 p. 7175 - 7177

665-27-0 ~% 2450-53-5

文献：Tetrahedron Letters, , vol. 52, # 52 p. 7175 - 7177

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