10102-18-8

10102-18-8结构式

常用中文名：亚硒酸钠
常用英文名：Sodium selenite
CAS号：10102-18-8
分子式：Na₂O₃Se
分子量：172.938
相关类别：无机化工无机盐金属卤化物及卤酸盐金属氯化物及盐
发布时间：2018-02-07 08:00:00
更新时间：2024-01-02 17:40:21
【用途一】
用于生物碱的检验和红色玻璃、釉彩的配制
【用途二】
用作饲料添加剂
【用途三】
硒是谷胱苷肽过氧化酶的组成部分，通过氧化作用维持细胞膜的功能，提高蛋白质的脂类性质的内源性抗氧化剂的产量。参与能量的转化，影响代谢，对脂肪的乳化、吸收和多种维生素的吸收起着极其重要的作用。同时还参与与辅酶A、辅酶Q的合成，影响其他生物酶系统的功能。对氨基酸的代谢、蛋白质的合成、糖类代谢、生物氧化都有影响。畜禽机体缺硒，会严重影响畜禽的生长发育和繁殖机能。
【用途四】
营养强化剂。

中文名	亚硒酸钠
英文名	disodium selenite
英文别名	Sodium selenite MFCD00003489 EINECS 233-267-9

熔点	350 °C
分子式	Na₂O₃Se
分子量	172.938
精确质量	173.880814
PSA	63.19000
外观性状	白色至淡米色晶体
储存条件	贮存于阴凉、通风仓库内。远离火种、热源。应与氧化剂、酸类、食用化工原料分开存放。不能与粮食、食物、种子、饲料、各种日用品混装、混运。
稳定性	1.白色结晶。可含有五个结晶水，在空气中稳定，在干燥空气中可失去水分。理论含硒量45.7%。在空气中稳定， 2.在干燥空气中易风化，有剧毒！吸入或吞入时有极毒，并具有蓄积性危害
水溶解性	950 g/L (20 ºC)
分子结构	1、摩尔折射率：无可用的 2、摩尔体积（cm³/mol）：无可用的 3、等张比容（90.2K）：无可用的 4、表面张力（dyne/cm）：无可用的 5、介电常数：无可用的 6、极化率（10^-24cm³）：无可用的 7、单一同位素质量：173.880806 Da 8、标称质量：174 Da 9、平均质量：173.9377 Da
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:0 3.氢键受体数量:3 4.可旋转化学键数量:0 5.互变异构体数量:无 6.拓扑分子极性表面积63.2 7.重原子数量:6 8.表面电荷:0 9.复杂度:18.8 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:3
更多	1. 性状：无色四方棱柱状结晶。无气味。在空气中稳定。对湿敏感。 2. 密度（g/mL,25℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：710 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,20ºC）：未确定 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：溶于水950 g/L (20 ºC)，不溶于乙醇。

第一部分：化学品名称

化学品中文名称：	亚硒酸钠
化学品英文名称：	Sodium selenite；Disodium selenite
中文俗名或商品名：
Synonyms：
CAS No.：	10102-18-8
分子式：	Na₂SeO₃
分子量：	172.94

第二部分：成分/组成信息

纯化学品混合物

化学品名称：亚硒酸钠

有害物成分

含量

CAS No.

第三部分：危险性概述

危险性类别：	第6．1类毒害品
侵入途径：	吸入食入经皮吸收
健康危害：	本品属高毒类。人经口摄取1克，能引起中毒死亡。急性中毒时可见：上呼吸道和眼睛、粘膜的刺激症状，头痛、眩晕、全身虚弱、恶心、呕吐、呼出气和皮肤有大蒜味等。皮肤接触小量本品可引起皮炎。
环境危害：
燃爆危险：	本品不燃，高毒，具刺激性。

第四部分：急救措施

皮肤接触：	用肥皂水及清水彻底冲洗。就医。
眼睛接触：	拉开眼睑，用流动清水冲洗15分钟。就医。
吸入：	脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。就医。
食入：	误服者，口服牛奶、豆浆或蛋清，就医。

第五部分：消防措施

危险特性：	受高热分解，放出有毒的烟气。
有害燃烧产物：	氧化硒、氧化钠、硒。
灭火方法及灭火剂：	消防人员必须穿全身防火防毒服，在上风向灭火。灭火剂:水。
消防员的个体防护：
禁止使用的灭火剂：
闪点(℃)：
自燃温度(℃)：
爆炸下限[%(V/V)]：
爆炸上限[%(V/V)]：
最小点火能(mJ)：
爆燃点：
爆速：
最大燃爆压力(MPa)：
建规火险分级：

第六部分：泄漏应急处理

应急处理：

隔离泄漏污染区，周围设警告标志，建议应急处理人员戴自给式呼吸器，穿化学防护服。不要直接接触泄漏物，用砂土吸收，铲入提桶，倒至空旷地方深埋。被污染地面用肥皂或洗涤剂刷洗，经稀释的污水放入废水系统。如大量泄漏，收集回收或无害处理后废弃。

第七部分：操作处置与储存

操作注意事项：	密闭操作，提供充分的局部排风。防止粉尘释放到车间空气中。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴防尘面具（全面罩），穿胶布防毒衣，戴橡胶手套。避免产生粉尘。避免与氧化剂、酸类接触。配备泄漏应急处理设备。倒空的容器可能残留有害物。
储存注意事项：	储存于阴凉、通风的库房。远离火种、热源。防止阳光直射。包装密封。应与氧化剂、酸类、食用化学品分开存放，切忌混储。储区应备有合适的材料收容泄漏物。

第八部分：接触控制/个体防护

最高容许浓度：	中国 MAC：未制订标准前苏联MAC：未制订标准美国TLV—TWA：0．2mg(Se)
监测方法：
工程控制：	严加密闭，提供充分的局部排风。尽可能机械化、自动化。
呼吸系统防护：	作业工人应该佩戴防尘口罩。紧急事态抢救或逃生时，应该佩戴防毒口罩。
眼睛防护：	戴化学安全防护眼镜。
身体防护：	穿相应的防护服。
手防护：	戴防化学品手套。
其他防护：	工作现场禁止吸烟、进食和饮水。工作后，淋浴更衣。单独存放被毒物污染的衣服，洗后再用。工作服不要带到非

第九部分：理化特性

外观与性状：	白色无臭的针状或柱状结晶或粉末。
pH：
熔点(℃)：	分解
沸点(℃)：
相对密度(水=1)：	5．96
相对蒸气密度(空气=1)：
饱和蒸气压(kPa)：
燃烧热(kJ/mol)：
临界温度(℃)：
临界压力(MPa)：
辛醇/水分配系数的对数值：
闪点(℃)：
引燃温度(℃)：
爆炸上限%(V/V)：
爆炸下限%(V/V)：
分子式：	Na₂SeO₃
分子量：	172.94
蒸发速率：
粘性：
溶解性：	溶于水，不溶于醇。
主要用途：	用作玻璃脱色剂、生物碱试剂。

第十部分：稳定性和反应活性

稳定性：	在常温常压下稳定
禁配物：	强氧化剂、强酸。
避免接触的条件：
聚合危害：	不能出现
分解产物：	氧化硒、氧化钠、硒。

第十一部分：毒理学资料

急性毒性：	LD50：7mg／kg(大鼠经口)；7mg／kg(小鼠经口) LC50：
急性中毒：
慢性中毒：
亚急性和慢性毒性：
刺激性：
致敏性：
致突变性：
致畸性：
致癌性：

第十二部分：生态学资料

生态毒理毒性：
生物降解性：
非生物降解性：
生物富集或生物积累性：

第十三部分：废弃处置

废弃物性质：
废弃处置方法：	建议用控制焚烧法或安全掩埋法处置。破损容器禁止重新使用，要在规定场所掩埋。
废弃注意事项：

第十四部分：运输信息

危险货物编号：	61016
UN编号：	2630
包装标志：
包装类别：	Ⅱ
包装方法：	塑料袋或二层牛皮纸袋外全开口或中开口钢桶（钢板厚1.0 毫米，每桶净重不超过150 公斤；钢板厚0.75毫米，每桶净重不超过100 公斤）。
运输注意事项：	储存于阴凉、通风仓间内。远离火种、热源。应严格执行极毒物品“五双”管理制度。操作现场不得吸烟、饮水、进食。应与氧化剂、酸类、食用化工原料分开存放。不能与粮食、食物、种子、饲料、各种日用品混装、混运。搬
RETCS号：
IMDG规则页码：

第十五部分：法规信息

国内化学品安全管理法规：

化学危险物品安全管理条例 (1987年2月17日国务院发布)，化学危险物品安全管理条例实施细则 (化劳发[1992] 677号)，工作场所安全使用化学品规定 ([1996]劳部发423号)等法规，针对化学危险品的安全使用、生产、储存、运输、装卸等方面均作了相应规定；常用危险化学品的分类及标志 (GB 13690-92)将该物质划为第6.1 类毒害品；剧毒物品分级、分类与品名编号(GA 57-93)中，该物质属第三类 B级无机剧毒品。

国际化学品安全管理法规：

第十六部分：其他信息

参考文献：	1.周国泰，化学危险品安全技术全书，化学工业出版社，1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编，化学品毒性法规环境数据手册，中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989
填表时间：	年月日
填表部门：
数据审核单位：
修改说明：
其他信息：	6
MSDS修改日期：	年月日

毒理学数据:

大鼠经LD50：7mg／kg。人经口摄取1g，能引起中毒死亡。

生态学数据:

通常对水体是稍微有害的，不要将未稀释或大量产品接触地下水，水道或污水系统，未经政府许可勿将材料排入周围环境。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VS7350000

CHEMICAL NAME :: Selenious acid, disodium salt

CAS REGISTRY NUMBER :: 10102-18-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 108

MOLECULAR FORMULA :: O3-Se.2Na

MOLECULAR WEIGHT :: 172.94

WISWESSER LINE NOTATION :: NA2 SE-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5476 ug/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6570 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7080 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Cardiac - other changes Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracervical

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1916 ug/kg

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction) Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Endocrine - hypoglycemia

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1971 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2530 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1971 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 6570 ug/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 2190 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 5060 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 8500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 3300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - horse, donkey

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Cardiac - pulse rate increase, without fall in BP Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cattle

DOSE/DURATION :: 9900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 1533 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5397 mg/kg/6W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 152 mg/kg/13W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - interstitial nephritis Kidney, Ureter, Bladder - changes in bladder weight Endocrine - effect on menstrual cycle

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1966 mg/kg/1Y-C

TOXIC EFFECTS :: Blood - normocytic anemia Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 942 mg/kg/2Y-C

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Kidney, Ureter, Bladder - other changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2541 ug/kg/33W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 13 gm/kg/5W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 168 mg/kg/6W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 58800 ug/kg/12W-C

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 384 mg/kg

SEX/DURATION :: male 34 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 15 mg/kg

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 999 mg/kg

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: female 8-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 112 mg/kg

SEX/DURATION :: female 6-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: female 8-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 45995 ug/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1729 ug/kg

SEX/DURATION :: female 16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 7890 ug/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 2836 ug/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1003 mg/kg

SEX/DURATION :: female 1-16 week(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 17290 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 2 mg/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 18,109,1983 *** REVIEWS *** ACGIH TLV-TWA 0.2 mg(Se)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,245,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 28,179,1941 TOXICOLOGY REVIEW PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 23,305,1943 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Se,112,1976 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.2 mg(Se)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,224,1971 OSHA PEL (Gen Indu):8H TWA 0.2 mg(Se)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.2 mg(Se)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.2 mg(Se)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.2 mg(Se)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-BELGIUM:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-DENMARK:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-FINLAND:TWA 0.1 mg(Se)/m3;STEL 0.3 mg(Se)/m3 JAN 1993 OEL-GERMANY:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-HUNGARY:STEL 0.1 mg(Se)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-POLAND:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-SWEDEN:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-TURKEY:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 mg(Se)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84379 No. of Facilities: 480 (estimated) No. of Industries: 5 No. of Occupations: 5 No. of Employees: 1198 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84379 No. of Facilities: 741 (estimated) No. of Industries: 7 No. of Occupations: 19 No. of Employees: 10544 (estimated) No. of Female Employees: 3736 (estimated)

符号	GHS06, GHS09
信号词	Danger
危害声明	H300 + H330-H315-H317-H319-H411
补充危害声明	Contact with acids liberates toxic gas.
警示性声明	Missing Phrase - N15.00950417-P260-P280-P304 + P340 + P310-P305 + P351 + P338-P403 + P233
个人防护装备	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲)	T+:Verytoxic;N:Dangerous for the environment;
风险声明 (欧洲)	R23;R28;R31;R43;R51/53
安全声明 (欧洲)	S28-S36/37-S45-S61-S28A
危险品运输编码	UN 2630 6.1/PG 1
WGK德国	2
RTECS号	VS7350000
包装等级	I
危险类别	6.1

7446-08-4

497-19-8

10102-18-8

文献：Brisdon, Alan K.; Gomme, Robin A.; Ogden, J. Steven Journal of Physical Chemistry, 1991 , vol. 95, # 7 p. 2927 - 2931

7446-08-4

497-19-8

10102-18-8

文献：Journal of Physical Chemistry, , vol. 95, # 7 p. 2927 - 2931

上游产品 2
7446-08-4 497-19-8
下游产品 0

1.硒与硝酸反应生成亚硒酸和二氧化氮，除去二氧化氮后，用氢氧化钠溶液中和，经加热浓缩、干燥研磨而得。

2.将五水亚硒酸钠Na2SeO3·5H2O用40℃左右的干燥空气使其风干即形成Na2SeO3。或者按完全中和的计量比，使氢氧化钠与亚硒酸的溶液混合，然后在60～100℃的温度下蒸发浓缩，此时即可形成无水亚硒酸钠的结晶。

3.由硒与硝酸生成氧化硒，再与氢氧化钠反应生成亚硒酸钠，经干燥、研磨而成。

4.按理论量将不含犆犗２－３离子的氢氧化钠溶液加到亚硒酸浓溶液中进行反应：

所得溶液在氯化钙真空干燥器内于室温下除去水分，并加入晶种使结晶析出，经抽滤后，于干燥器中干燥，即得亚硒酸钠水合物。将所得反应液于60～100℃下蒸发、结晶、脱水、干燥，即可得无水亚硒酸钠。

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