7758-23-8

• 常用中文名：磷酸二氢钙
• 常用英文名：Monocalcium phosphate
• CAS号：7758-23-8
• 分子式：CaH₄O₈P₂
• 分子量：234.053
• 相关类别： 食品添加剂 水分保持剂
• 发布时间：2018-06-25 16:19:33
• 更新时间：2024-01-02 16:14:23
• 磷酸二氢钙是一种生物化学试剂,可作为生物材料或有机化合物进行生命科学相关研究。
• 密度： 2.22（16/4℃）
  性状： 无色三斜晶系结晶或白色结晶性粉末。
  溶解性： 易溶于盐酸、硝酸，微溶于冷水，几乎不溶于乙醇。

名称

• 中文名: 磷酸二氢钙
• 英文名: calcium bis(dihydrogenphosphate)
• 中文别名: 相关CAS：10031-30-8; 磷酸一钙,酸性磷酸钙; 二磷酸四氢钙
• 英文别名: Monocalcium phosphate; Calcium bis(dihydrogen phosphate); Calcium monobasic phosphate; Calcium biphosphate; calcium superphosphate; calcium,dihydrogen phosphate; CALCIUM PHOSPHATE MONOBASIC; MFCD00010898; EINECS 231-837-1; QPQQO &&Ca salt 2:1; Calcium dihydrogen phosphate; Monobasic calcium phosphate; Calcium Dihydrogenphoshate

物化性质

• 密度: 2.22（16/4℃）
• 沸点: 158ºC at 760 mmHg
• 分子式: CaH₄O₈P₂
• 分子量: 234.053
• 精确质量: 233.900726
• PSA: 180.80000
• 外观性状: 白色结晶粉末
• 储存条件:

  应贮存在阴凉、避光、干燥的库房内

• 稳定性:

  1.呈强酸性。100℃时结晶水，200℃时分解。

• 水溶解性: insoluble
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:4

  3.氢键受体数量:8

  4.可旋转化学键数量:0

  5.互变异构体数量:无

  6.拓扑分子极性表面积161

  7.重原子数量:11

  8.表面电荷:0

  9.复杂度:49.8

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:3

• 更多:

  1. 性状：无色三斜晶系结晶或白色结晶性粉末

  2. 密度（g/mL 25ºC）：2.22

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC，常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率（n20/D）：未确定

  8. 闪点（ºC，）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值（25℃）：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性(mg/mL)：易溶于盐酸、硝酸，微溶于冷水，几乎不溶于乙醇，水溶液呈酸性。

生物活性

• 描述: 磷酸二氢钙是一种生物化学试剂,可作为生物材料或有机化合物进行生命科学相关研究。
• 相关类别:
  研究领域 >> 其他

MSDS

Name: Calcium Phosphate Monobasic Material Safety Data Sheet Synonym: Phosphoric acid calcium sal CAS: 7758-23-8 Section 1 - Chemical Product MSDS Name:Calcium Phosphate Monobasic Material Safety Data Sheet Synonym:Phosphoric acid calcium sal Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 7758-23-8 Calcium Phosphate, Monobasic 100 231-837-1 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Not available. Potential Health Effects Eye: Causes eye irritation. May result in corneal injury. Skin: Causes skin irritation. Ingestion: Causes gastrointestinal irritation with nausea, vomiting and diarrhea. Inhalation: Dust is irritating to the respiratory tract. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Ingestion: Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: Remove from exposure and move to fresh air immediately. Get medical aid if cough or other symptoms appear. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Section 7 - HANDLING and STORAGE Handling: Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 7758-23-8: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white Odor: Odorless. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not applicable. Freezing/Melting Point: 392 deg F Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: 392 deg F Solubility in water: 1.8% Specific Gravity/Density: 2.22 @18C Molecular Formula: Ca(HPO4)2 Molecular Weight: 232.0368 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Dust generation. Incompatibilities with Other Materials: None reported. Hazardous Decomposition Products: Oxides of phosphorus. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 7758-23-8: TB8527000 LD50/LC50: CAS# 7758-23-8: Oral, mouse: LD50 = 15250 mg/kg; Oral, rat: LD50 = 3986 mg/kg; Skin, rabbit: LD50 = >2 gm/kg. Carcinogenicity: Calcium Phosphate, Monobasic - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: WGK (Water Danger/Protection) CAS# 7758-23-8: 0 Canada CAS# 7758-23-8 is listed on Canada's DSL List. CAS# 7758-23-8 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 7758-23-8 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: ADI＝0～70mg/kg（以磷计）。面包类用丙酸钙作防腐剂时，面团的ph值上升，使发酵缓慢，此时宜添加本品0.3%，以降低面团的ph值 CHEMICAL IDENTIFICATION RTECS NUMBER : TB8527000 CAS REGISTRY NUMBER : 7758-23-8 LAST UPDATED : 199710 DATA ITEMS CITED : 6 MOLECULAR FORMULA : Ca.2H3-O4-P MOLECULAR WEIGHT : 236.08 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 17500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(12),87,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(12),87,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84097 No. of Facilities: 661 (estimated) No. of Industries: 11 No. of Occupations: 35 No. of Employees: 14370 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84097 No. of Facilities: 990 (estimated) No. of Industries: 9 No. of Occupations: 14 No. of Employees: 18990 (estimated) No. of Female Employees: 5892 (estimated)

安全

• 危害码 (欧洲): Xi:Irritant
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S36/37-S37/39
• WGK德国: 2
• RTECS号: TB8527000
• 海关编码: 2835260000

制备

1.石灰法
用石灰中和食品级磷酸，控制终点为Ph值3.2，即得磷酸二氢钙。
CaCO3+2H3P04→Ca(H2PO4)2+H20+CO2↑
2.磷酸氢钙法
由食品级磷酸氢钙或食品级磷酸三钙与食品级磷酸溶液中和，控制终点为Ph值3.2；再经浓缩、结晶即得产品。
CaHPO4+H3P04→Ca(H2PO4)2

3.采用磷酸氢钙法。将食用磷酸氢钙溶解于食用磷酸中，控制ｐＨ值在3.2左右时生成磷酸二氢钙，经浓缩、冷却结晶、离心分离、干燥，制得食用磷酸二氢钙成品。其反应式如下。

4.将磷酸和氢氧化钙混合，并调节反应液ph值为3.2左右，进行反应：

反应结束后，过滤，滤液经蒸发浓缩，在0℃时冷却结晶，离心甩干，结晶用丙酮充分洗涤后，风干即可。

海关

海关编码	2835260000