25442-42-6

• 常用中文名：5’-三苯甲基-2’-脱氧-2,3’-双脱氢胸苷
• 常用英文名：5-O-Triphenylmethyl-2-deoxy-2,3-didehyrothymidine
• CAS号：25442-42-6
• 分子式：C₂₉H₂₆N₂O₄
• 分子量：466.528
• 发布时间：2018-10-12 21:13:44
• 更新时间：2026-07-10 15:52:30

名称

• 中文名: 5’-三苯甲基-2’-脱氧-2,3’-双脱氢胸苷
• 英文名: 5-O-Trityl-2,3,-anhydrothymidine
• 中文别名: 5'-三苯基-2'-脱氧-2,3'-双脱氢胸苷; 5'-O-三苯甲基-2,3'-脱水胸苷; (2R,3R,5R)-8-甲基-3-((三苯甲基氧基)甲基)-2,3-二氢-5H,9H-2,5-甲并嘧啶并[2,1-B][1,5,3] 二氧氮杂庚烷-9-酮; 5-O-三苯基-2,3′-无水胸苷; 2,3'-脱水5'-O-三苯甲基; 5'-三苯甲基-2'-脱氧-2,3'-双脱氢胸苷
• 英文别名: 5''-O-TRITYL-2,3''-ANHYDROTHYMIDINE (5-OTT+1); 5-O-Trityl-2,3’-anhydrothymidine; 2,3-dihydro-8-methyl-3-[(trityloxy)methyl]-2,5-methano-5h,9h-pyrimido[2,1-b][1,5,3]dioxazin-9-one; 5-O-TRITYL-2',3'-ANHYDROTHYMIDINE; (2R,3R,5R)-2,3-Dihydro-8-methyl-3-[(triphenylmethoxy)methyl]-2,5-methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazin-9-one; (2R,3R,5R)-8-Methyl-3-((trityloxy)methyl)-2,3-dihydro-2,5-methanopyrimido[2,1-b][1,5,3]dioxazin-9(5H)-one; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(triphenylMethoxy)Methyl]oxolan-2-yl]-5-Methyl-1,3-diazinane-2,4-dione; 2,3'-Anhydro-1-(2-deoxy-5-O-trityl-.beta.-D-threo-pentofuranosyl)thymine; 5'-O-Trityl-2,3'-anhydrothyMidine (Zidovudine); 5'-Trityl-2'-deoxy-2,3'-didehydrothymidine; 2',3'-Anhydro-5-O-tritylthymidine; 5'-o-Triphenylmethyl-2-deoxy-2',3-didehydrothymidine; 2,3'-Anhydro-1-(2-deoxy-5-O-trityl-b-D-threo-pentofuranosyl)-thymine; (1R,9R,10R)-4-Methyl-10-[(trityloxy)methyl]-8,11-dioxa-2,6-diazatricyclo[7.2.1.0]dodeca-3,6-dien-5-one; 5-Trityl-2-deoxy-2-didehydrothymidine; (2r,3r,5r)-8-Methyl-3-((trityloxy)methyl)-2,3-dihydro-5h,9h-2,5-methanopyrimido[2,1-b][1,5,3]dioxazin-9-one; 5’-O-Trityl-2,3’-anhydrothymidine; 2,5-Methano-5H,9H-pyrimido[2,1-b][1,5,3]dioxazin-9-one, 2,3-dihydro-8-methyl-3-[(triphenylmethoxy)methyl]-, (2R,3R,5R); 5-Methyl-1-{(2R,5S)-5-[(trityloxy)methyl]-2,5-dihydro-2-furanyl}-2,4(1H,3H)-pyrimidinedione; 8-methyl-3-((trityloxy)methyl)-2,3,10,10a-tetrahydro-2,5-methanopyrimido[2,1-b][1,5,3]dioxazin-9(5H)-one

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 595.7±60.0 °C at 760 mmHg
• 分子式: C₂₉H₂₆N₂O₄
• 分子量: 466.528
• 闪点: 314.1±32.9 °C
• 精确质量: 466.189270
• PSA: 62.58000
• LogP: 5.59
• 外观性状: 白色固体
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.617

合成路线

7791-71-1 ~97% 25442-42-6

文献：No; Dong Seong Shin; Bok Ju Song; Ahn; Ha Synthetic Communications, 2000 , vol. 30, # 21 p. 3873 - 3882

42214-24-4 ~85% 25442-42-6

文献：Costa, Anna M.; Faja, Montserrat; Farras, Jaume; Vilarrasa, Jaume Tetrahedron Letters, 1998 , vol. 39, # 13 p. 1835 - 1838

42214-24-4 ~15% 25442-42-6 66503-47-7 29706-84-1

文献：European Journal of Medicinal Chemistry, , vol. 20, # 4 p. 295 - 301

7791-71-1 ~19% 25442-42-6 66503-47-7

文献：Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 306 - 310

131933-43-2 ~23% 25442-42-6

文献：Cosford; Schinazi Journal of Organic Chemistry, 1991 , vol. 56, # 6 p. 2161 - 2165

25442-44-8 ~% 25442-42-6

文献：Journal of Fluorine Chemistry, , vol. 56, # 1 p. 55 - 76

76-83-5 ~% 25442-42-6

文献：Synthetic Communications, , vol. 30, # 21 p. 3873 - 3882

50-89-5 ~% 25442-42-6

文献：Synthetic Communications, , vol. 30, # 21 p. 3873 - 3882

64-17-5 42214-24-4 ~33% 25442-42-6 5964-41-0 详细

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 19 p. 2695 - 2698

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