29274-22-4

• 常用中文名：吡唑并[1,5-A]嘧啶-5(4H)-酮
• 常用英文名：Pyrazolo[1,5-a]pyrimidin-5-ol
• CAS号：29274-22-4
• 分子式：C₆H₅N₃O
• 分子量：135.123
• 相关类别： 医药中间体 杂环化合物 嘧啶类化合物 酮类
• 发布时间：2018-10-22 19:02:12
• 更新时间：2024-01-08 11:52:58

名称

• 中文名: 吡唑并[1,5-a]嘧啶-5(4H)-酮
• 英文名: 1H-pyrazolo[1,5-a]pyrimidin-5-one
• 英文别名: 5-Oxo-4,5-dihydropyrazolo<1,5-a>pyrimidin; 5-Hydroxypyrazolo[1,5-a]pyrimidine; pyrazolo[1,5-a]pyrimidin-5-ol; Pyrazolo[1,5-a]pyrimidin-5(4H)-one

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 243.174ºC at 760 mmHg
• 分子式: C₆H₅N₃O
• 分子量: 135.123
• 闪点: 100.868ºC
• 精确质量: 135.043259
• PSA: 50.42000
• LogP: 0.18
• 蒸汽压: 0.033mmHg at 25°C
• 折射率: 1.739
• 储存条件: 室温，干燥

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

合成路线

1224944-43-7 ~82% 29274-22-4

文献：Hanan, Emily J.; Van Abbema, Anne; Barrett, Kathy; Blair, Wade S.; Blaney, Jeff; Chang, Christine; Eigenbrot, Charles; Flynn, Sean; Gibbons, Paul; Hurley, Christopher A.; Kenny, Jane R.; Kulagowski, Janusz; Lee, Leslie; Magnuson, Steven R.; Morris, Claire; Murray, Jeremy; Pastor, Richard M.; Rawson, Tom; Siu, Michael; Ultsch, Mark; Zhou, Aihe; Sampath, Deepak; Lyssikatos, Joseph P. Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 10090 - 10107

874-14-6 1225387-53-0 ~56% 29274-22-4

文献：ELAN PHARMACEUTICALS, INC.; SHAM, Hing, L.; KONRADI, Andrei, W.; HOM, Roy, K.; PROBST, Gary, D.; BOWERS, Simeon; TRUONG, Anh; NEITZ, R., Jeffrey; SEALY, Jennifer; TOTH, Gergely Patent: WO2010/91310 A1, 2010 ; Location in patent: Page/Page column 141 ; WO 2010/091310 A1

1820-80-0 623-47-2 ~34% 29274-22-4

文献：GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling Patent: WO2013/127268 A1, 2013 ; Location in patent: Page/Page column 68 ;

89464-32-4 623-47-2 ~34% 29274-22-4

文献：GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; GOSSELIN, Francis; ZAK, Mark; ZHENG, Xiaozhang Patent: WO2013/130935 A1, 2013 ; Location in patent: Paragraph 0209 ;

1001-26-9 1225387-53-0 ~61% 29274-22-4

文献：Gavrin, Lori K.; Lee, Arthur; Provencher, Brian A.; Massefski, Walter W.; Huhn, Stephen D.; Ciszewski, Gregory M.; Cole, Derek C.; McKew, John C. Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 1043 - 1046

922-67-8 1225387-53-0 ~% 29274-22-4

文献：MERZ PHARMA GMBH andamp; CO. KGaA; HENRICH, Markus; WEIL, Tanja; NAGEL, Jens; GRAVIUS, Andreas; MUeLLER, Sibylle; KAUSS, Valerjans; ZEMRIBO, Ronalds; FOTINS, Juris Patent: WO2010/63487 A1, 2010 ; Location in patent: Page/Page column 68 ; WO 2010/063487 A1

874-14-6 1820-80-0 ~% 29274-22-4

文献：Bowers, Simeon; Truong, Anh P.; Jeffrey Neitz; Hom, Roy K.; Sealy, Jennifer M.; Probst, Gary D.; Quincy, David; Peterson, Brian; Chan, Wayman; Galemmo Jr., Robert A.; Konradi, Andrei W.; Sham, Hing L.; Toth, Gergely; Pan, Hu; Lin, May; Yao, Nanhua; Artis, Dean R.; Zhang, Heather; Chen, Linda; Dryer, Mark; Samant, Bhushan; Zmolek, Wes; Wong, Karina; Lorentzen, Colin; Goldbach, Erich; Tonn, George; Quinn, Kevin P.; Sauer, John-Michael; Wright, Sarah; Powell, Kyle; Ruslim, Lany; Ren, Zhao; Bard, Frederique; Yednock, Ted A.; Griswold-Prenner, Irene Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5521 - 5527

上下游产品

上游产品  7
1224944-43-7 874-14-6 1225387-53-0 1820-80-0
623-47-2 1001-26-9 922-67-8
下游产品  3
960613-96-1 1198569-35-5 29274-24-6

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%