721-50-6

• 常用中文名：丙胺卡因
• 常用英文名：Prilocaine
• CAS号：721-50-6
• 分子式：C₁₃H₂₀N₂O
• 分子量：220.311
• 相关类别： 原料药 Anesthetic Agents Local anesthetics
• 发布时间：2018-08-21 18:06:40
• 更新时间：2026-07-23 20:08:33
• Prilocaine是局麻化合物。

名称

• 中文名: 丙胺卡因
• 英文名: prilocaine
• 中文别名: 丙氨卡因 N-(2-甲基苯基)-2-丙胺-丙酰胺; 丙胺卡因杂质E; N-(2-甲基苯基)-2-丙胺-丙酰胺; PRILOCAINE 丙胺卡因; 丙胺卡因(碱基); DNA连接酶抑制剂(L67); 盐酸丙胺卡; PRILOCAINE 化学试剂; 丙胺卡因,10 MM DMSO 溶液; 2-(丙基氨基)-N-(邻甲苯基)丙酰胺; 丙安卡因碱; 丙胺卡因:DNA连接酶抑制剂; N-(2-甲基苯基)-2; 丙胺卡因中间体; Prilocaine 10mM * 1mL in DMSO试剂; 丙氨卡因; 丙胺卡因; 丙胺卡因/B1A; Prilocaine 5mg试剂; 普利卡因; 丙胺卡因(局麻药)丙胺卡因丙氨卡因; 丙胺卡因标准品; 丙胺卡因游离碱
• 英文别名: 2-(PropylaMino)-N-(o-tolyl)propanaMide; Prilocaine 13C D3; n-(2-methylphenyl)-2-(propylamino)-propanamid; PRILOCAINE BASE; o-Methyl-2-propylaminopropionanilide; 2-(propylamino)propion-o-toluidide; N-(2-Methylphenyl)-N-propylalaninamide; PRILOCAINE P; Citanest; PRILOCAINE; MFCD00048681; European Mket, Prilocaine Powder for Relieving Pain Prilocaine Price -6; PRILOCAINE P(CRM STANDD); PRILOCAINE HCL; 2-Methyl-alpha-propylaminopropionanilide; o-Methyl-alpha-propylaminopropionanilide; (±)-2′-Methyl-2-(propylamino)propionanilide; n-(2-methylphenyl)-2-propylamino-propanamide; Prilocaine Cas number:(-6); UNII:046O35D44R; Astra 1515; Astra 1512; astra1515; IN STOCK PRILOCAINE BASE CAS NO.-6; astra1512; l67; prilocainum [INN_la]; (+-)-N-(2-Propylaminopropionyl)-2-toluidine; 2-(Propylamino)-o-propionotoluidide; Pricocaine; L 67; PRILOCAINE BASE CAS NO.-6; alpha-n-Propyl-amino-2-methylpropionanilide; 2-(propylamino)-o-propionotoluidid; PRILOCAINE API; Anesthesia Mivacaine CAS NO. -6; Prilocaine N-(2-Methylphenyl)-2-propylamino-propanamide; Prilocainc; N-(2-méthylphényl)-2-(propylamino)propanamide; EINECS 211-957-0; o-Propionotuluidide, 2-propylamino; β-Amyloid ptide; o-Propionotoluidide, 2-(propylamino); Bulk Supply Prilocaine; N-(2-Methylphenyl)-2-(propylamino)propanamid; N-(2-methylphenyl)-N2-propylalaninamide; Astra; Priloca; DL-(+-)-Prilocaine; Prilocain; Propanamide, N-(2-methylphenyl)-2-(propylamino); Prilocaine //BP; o-Propionotoluidide, 2-(propylamino)- (6CI, 8CI); N-(2,6-Dimethylphenyl)-2-(propylamino)propanamide; 2-Methyl-a-propylaminopropionanilide; alpha-n-propylamino-2-methylpropionanilide; N1-(2-methylphenyl)-N2-propylalaninamide; Prilocaine HCl (base); Propitocaine; Propanamide, N-(2-methylphenyl)-2-(propylamino)- (9CI); N-(2-methylphenyl)-2-(propylamino)propionamide

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 361.6±25.0 °C at 760 mmHg
• 熔点: 37-38ºC
• 分子式: C₁₃H₂₀N₂O
• 分子量: 220.311
• 闪点: 134.3±23.3 °C
• 精确质量: 220.157562
• PSA: 41.13000
• LogP: 1.74
• 外观性状: 白色结晶粉末
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.543
• 储存条件: -20°C
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:2

  3.氢键受体数量:2

  4.可旋转化学键数量:5

  5.互变异构体数量:3

  6.拓扑分子极性表面积:41.1

  7.重原子数量:16

  8.表面电荷:0

  9.复杂度:218

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:1

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

生物活性

• 描述: Prilocaine是局麻化合物。
• 相关类别:
  信号通路 >> 跨膜转运 >> Na+/K+ATP酶
  天然产物 >> 其他
  研究领域 >> 其他
• 参考文献:

  [1]. Eriksson E. Prilocaine. An experimental study in man of a new local anaesthetic with special regards to efficacy, toxicity and excretion. Acta Chir Scand Suppl. 1966;358:1-82.

  [2]. Juhlin L, et al. EMLA: a new topical anesthetic. Adv Dermatol. 1990;5:75-91; discussion 92.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UG5760000 CHEMICAL NAME : o-Propionotoluidide, 2-(propylamino)- CAS REGISTRY NUMBER : 721-50-6 LAST UPDATED : 199706 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C13-H20-N2-O MOLECULAR WEIGHT : 220.35 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 231 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,455,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 519 mg/kg TOXIC EFFECTS : Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - hair REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,455,1965 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 59900 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 61,455,1965

安全

• 海关编码: 2924299090

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%