6376-26-7

• 常用中文名：沙维林
• 常用英文名：salverine
• CAS号：6376-26-7
• 分子式：C₁₉H₂₄N₂O₂
• 分子量：312.40600
• 发布时间：2018-05-03 08:00:00
• 更新时间：2024-01-31 15:09:23

名称

• 中文名: 沙维林
• 英文名: 2-[2-(diethylamino)ethoxy]-N-phenylbenzamide
• 英文别名: Salverinum [INN-Latin]; 2-(2-(Diethylamino)ethoxy)benzanilide; o-(Diethylaminoethoxy)benzanilide; EINECS 228-944-0; Salverine; Salverina [INN-Spanish]; Sch 1317; o-Diaethylaminoaethoxy-benzanilid [German]

物化性质

• 密度: 1.107g/cm3
• 沸点: 396.9ºC at 760 mmHg
• 分子式: C₁₉H₂₄N₂O₂
• 分子量: 312.40600
• 闪点: 193.8ºC
• 精确质量: 312.18400
• PSA: 41.57000
• LogP: 3.73250
• 折射率: 1.583

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CV7525000 CHEMICAL NAME : Benzanilide, 2-(2-(diethylamino)ethoxy)- CAS REGISTRY NUMBER : 6376-26-7 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C19-H24-N2-O2 MOLECULAR WEIGHT : 312.45 WISWESSER LINE NOTATION : 2N2&2OR BVMR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 335 mg/kg TOXIC EFFECTS : Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 16,1127,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 101,785,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 225 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,658,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 29 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 16,1127,1966 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 8 gm/kg/4W-I TOXIC EFFECTS : Related to Chronic Data - death Related to Chronic Data - changes in testicular weight REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 16,1127,1966 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 950 mg/kg SEX/DURATION : female 1-19 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,658,1968 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 1425 mg/kg SEX/DURATION : female 1-19 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,658,1968