52391-89-6

• 常用中文名：7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
• 常用英文名：7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
• CAS号：52391-89-6
• 分子式：C₁₆H₁₂ClFN₂O₂
• 分子量：318.73000
• 发布时间：2017-06-30 07:21:11
• 更新时间：2024-01-11 16:41:50

名称

• 英文名: 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one
• 英文别名: FLUTEMAZEPAM; Flutemazepam [INN]; Flutemazepamum [Latin]; EINECS 257-892-1; 7-Chloro-1,3-dihydro-1-methyl-3-hydroxy-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one; Sas-646; 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one,1,3-dihydro-7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-methyl

物化性质

• 密度: 1.4g/cm3
• 沸点: 550.3ºC at 760mmHg
• 分子式: C₁₆H₁₂ClFN₂O₂
• 分子量: 318.73000
• 闪点: 286.6ºC
• 精确质量: 318.05700
• PSA: 52.90000
• LogP: 2.11190
• 折射率: 1.641

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DF2370300 CHEMICAL NAME : 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-m ethyl- CAS REGISTRY NUMBER : 52391-89-6 BEILSTEIN REFERENCE NO. : 0688457 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C16-H12-Cl-F-N2-O2 MOLECULAR WEIGHT : 318.75 WISWESSER LINE NOTATION : T67 GNV JN IHJ CG G1 IQ KR BF HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968- Volume(issue)/page/year: 12,74,1974

合成路线

89722-84-9 ~% 52391-89-6

文献：Middleton, W. J.; Bingham, E. M.; Smith, D. H. Journal of Fluorine Chemistry, 1983 , vol. 23, p. 557 - 572

41300-29-2 ~% 52391-89-6

文献：Middleton, W. J.; Bingham, E. M.; Smith, D. H. Journal of Fluorine Chemistry, 1983 , vol. 23, p. 557 - 572

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