| 中文名 |
D-泛酸
|
| 英文名 |
(R)-pantothenic acid
|
| 中文别名 |
D(+)-N-(2,4-二羥-3,3-二甲丁醯基)-Β-胺丙酸
本多生酸
D-泛酸钙
泛酸
(R)-N-(2,4-二羟基-3,3-二甲基-1-氧代丁基)-β-丙氨酸
N-(2,4-二羟基-3,3-二甲基丁酰)-β-丙氨酸
维生素 B5
|
| 英文别名 |
kyselinapantothenova
pantothenic acid
PANTOTHENOIC ACID
d-pantothenicaci
D-(+)-Pantothenic acid
Pantothenic
D-(+)-Pantothenyl alcohol
(+)-Pantothenic acid
(R)-Pantothenate
(R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-b-alanine
Pantothenic acid, D- (8CI)
D(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-b-alanine
β-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-
D(+)-N-(2,4-dihydroxy-3,3-dimethylbutyryl)-β-alanine
Pantothenylol
Pantothenate
N-[(2R)-2,4-Dihydroxy-3,3-dimethylbutanoyl]-β-alanine
chick antidermatitis factor
VITAMIN B5
Ca pantothenaat
(R)-Pantothenic acid
D-VITAMIN B(5)
Pantothenic acid, D-
D-PANTOTHENIC ACID
|
| 密度 |
1.266 |
| 沸点 |
490.2±55.0 °C at 760 mmHg |
| 熔点 |
178-179ºC |
| 分子式 |
C9H17NO5 |
| 分子量 |
219.235 |
| 闪点 |
250.3±31.5 °C |
| 精确质量 |
219.110672 |
| PSA |
106.86000 |
| LogP |
-0.35 |
| 外观性状 |
白色或类白色固体 |
| 蒸汽压 |
0.0±2.8 mmHg at 25°C |
| 折射率 |
1.510 |
| 储存条件 |
室温 |
CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
RU4729000
-
CHEMICAL NAME :
-
Pantothenic acid, D-
-
CAS REGISTRY NUMBER :
-
79-83-4
-
BEILSTEIN REFERENCE NO. :
-
1727064
-
LAST UPDATED :
-
199612
-
DATA ITEMS CITED :
-
6
-
MOLECULAR FORMULA :
-
C9-H17-N-O5
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
3500 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(1),139,1987
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
1443 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
-
REFERENCE :
-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 17,32,1983
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
2500 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(1),139,1987
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Unreported
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
2490 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
BTMNA7 Bitamin. (Nippon Bitamin Gakkai, 4 Ushinomiya-cho, Yoshida, Sakyo-Ku, Kyoto 606, Japan) V.1- 1948- Volume(issue)/page/year: 25,297,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81917 No. of Facilities: 862 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1035 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81917 No. of Facilities: 234 (estimated) No. of Industries: 3 No. of Occupations: 10 No. of Employees: 4854 (estimated) No. of Female Employees: 52 (estimated)
|
【方法1】
由于泛酸具有很强的吸湿性，难以结晶，所以通常制成钙盐和钠盐。D-泛酸亦天然存在，具有生理活性，其工业生产方法参见泛酸钙条。
【方法2】
由本多生酸钙与硫酸反应制得。
