79-83-4

• 常用中文名：泛酸
• 常用英文名：D-Pantothenic acid
• CAS号：79-83-4
• 分子式：C₉H₁₇NO₅
• 分子量：219.235
• 相关类别： 原料药 饲料药物添加剂
• 发布时间：2018-02-04 08:00:00
• 更新时间：2026-07-03 22:12:21
• D-Pantothenic acid(pantothenate)即维生素B5,是水溶性维生素。

名称

• 中文名: D-泛酸
• 英文名: (R)-pantothenic acid
• 中文别名: 水中D-泛酸溶液标准物质; 泛酸 单体; D-泛酸（储存“℃”；运输“冰袋”）; D-泛酸/维生素B5; N-(2,4-二羟基-3,3-二甲基丁酰)-β-丙氨酸; D-泛酸标准品; D(+)-N-(2,4-二羥-3,3-二甲丁醯基)-Β-胺丙酸; 维生素B5-13C,15N,泛酸*标准物质; 泛酸(维生素B5); D-泛酸钙; 维生素 B5; 婴儿配方奶粉中泛酸/GB 53; D-泛酸钙的原料药; D-泛酸(储存“℃”; (R)-N-(2,4-二羟基-3,3-二甲基-1-氧代丁基)-B-丙氨酸; (R)-N-(2,4-二羟基-3,3-二甲基-1-氧代丁基)-BETA-丙氨酸; (+)-(R)-3-(2,4-二羟基-3,3-二甲基丁酰胺基)丙酸; 本多生酸; 维生素B5 D-泛酸钙 泛酸; 泛酸(工业级,含内酯); (R)-3-(2,4-二羟基-3,3-二甲基丁酰氨基)丙酸; 维生素B5,D-泛酸; 水中D-泛酸; D-泛酸,10 MM DMSO 溶液; 对照品/D-泛酸; D-泛酸(D-泛酸钙); 泛酸溶液,1000ΜG/ML; 维生素B5(泛酸); (R)-N-(2,4-二羟基-3,3-二甲基-1-氧代丁基)-β-丙氨酸; 水中泛酸溶液标准物质
• 英文别名: D-Pantothenic acid, 10 mM in DMSO; (d,+)-n(alpha-gamma-dihydroxy-beta,beta-dimethylbutyryl)-beta-alanine; 3-[[(2R)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]propanoic acid; Colesevelam Impurity 11; (R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-b-alanine; 4-dihydroxy-3,3-dimethyl-1-oxobutyl)-n-((r)-beta-alanin; D(+)-N-(2,4-dihydroxy-3,3-dimethylbutyryl)-β-alanine; D(+)-N-(2,4-Dihy-droxy-3,3-dimethylbutyryl)-alanine; chick antidermatitis factor; D-Pantothenic acid Solution, 1000μg/mL; D-VITAMIN B; Calcium pantothete; D-VITAMIN B(5); D-PANTOTHENIC ACID; kyselinapantothenova; chickantidermatitisfactor; D-PANTOTHENIC ACID //BP; D-(+)-Pantothenic acid; pantothenicacid; Pantothenylol; N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-β-alanine; D-calcim pantothenate; (R)-pantothenicaci; (-)-3-[[(S)-2,4-Dihydroxy-3,3-dimethylbutyryl]amino]propionic acid; (R)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-beta-alanine; Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-,5-methylbenzenesulfonate; PANTOTHENATE; pantothenic acid; (R)-3-(2,4-Dihydroxy-3,3-dimethylbutanamido)propionic Acid; Pantothenic; N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,(R)-.beta.-Alanine; D-(+)-Pantothenyl alcohol; beta.-Alanine, N-(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl; D(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-b-alanine; (R)-3-(2,4-Dihydroxy-3,3-diMethylbutanaMido)propanoic acid; 3-[(2R)-2,4-dihydroxy-3,3-diMethylbutanaMido]propanoic acid; β-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, (R); vitaminb5,pantothenicacid,pantothenate; β-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]; (VITAMIN B5,D-PANTOTHENIC ACID) ADE; N-[(2R)-2,4-Dihydroxy-3,3-dimethylbutanoyl]-β-alanine; Pantothenic acid (Vitamin B5); (+)-(R)-3-(2,4-Dihydroxy-3,3-dimethylbutanamido)propanoic acid; VITAMIN B5; Ca pantothenaat; (R)-Pantothenic acid; Vitamin B5-13C,15N; (+)-pantothenicacid; D.CALCIUM PANTOTHENATE /IP; PANTOTHENOIC ACID; d-pantothenicaci; Pantothenic acid(pantothenate); (+)-Pantothenic acid; (R)-Pantothenate; Pantothenic acid, D- (8CI); D-Pantothenic acid(Vitamin B5); Pantothenate; D-Pantothenic acid - ade

物化性质

• 密度: 1.266
• 沸点: 490.2±55.0 °C at 760 mmHg
• 熔点: 178-179ºC
• 分子式: C₉H₁₇NO₅
• 分子量: 219.235
• 闪点: 250.3±31.5 °C
• 精确质量: 219.110672
• PSA: 106.86000
• LogP: -0.35
• 外观性状: 白色或类白色固体
• 蒸汽压: 0.0±2.8 mmHg at 25°C
• 折射率: 1.510
• 储存条件: 室温

生物活性

• 描述: D-Pantothenic acid(pantothenate)即维生素B5,是水溶性维生素。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
  天然产物 >> 其他
• 参考文献:

  [1]. http://en.wikipedia.org/wiki/Pantothenic_acid

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RU4729000 CHEMICAL NAME : Pantothenic acid, D- CAS REGISTRY NUMBER : 79-83-4 BEILSTEIN REFERENCE NO. : 1727064 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C9-H17-N-O5 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(1),139,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1443 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 17,32,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(1),139,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2490 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BTMNA7 Bitamin. (Nippon Bitamin Gakkai, 4 Ushinomiya-cho, Yoshida, Sakyo-Ku, Kyoto 606, Japan) V.1- 1948- Volume(issue)/page/year: 25,297,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81917 No. of Facilities: 862 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1035 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81917 No. of Facilities: 234 (estimated) No. of Industries: 3 No. of Occupations: 10 No. of Employees: 4854 (estimated) No. of Female Employees: 52 (estimated)

安全

• 危害码 (欧洲): Xi

合成路线

上下游产品

上游产品  7
599-04-2 924-73-2 107-95-9 27778-35-4
867-81-2 1112-33-0 81-13-0
下游产品  6
85-61-0 599-04-2 107-95-9 67755-97-9
124-38-9 138148-35-3

制备

【方法1】
由于泛酸具有很强的吸湿性，难以结晶，所以通常制成钙盐和钠盐。D-泛酸亦天然存在，具有生理活性，其工业生产方法参见泛酸钙条。
【方法2】
由本多生酸钙与硫酸反应制得。