149-15-5

• 常用中文名：硫酸丁丙卡因
• 常用英文名：Butacaine sulfate
• CAS号：149-15-5
• 分子式：C₃₆H₆₂N₄O₈S
• 分子量：710.96400
• 发布时间：2018-06-28 20:00:25
• 更新时间：2024-01-11 21:26:43
• Butacaine sulfate, a white crystalline ester that is applied to mucous membranes as a local anesthetic.

名称

• 中文名: 硫酸丁丙卡因
• 英文名: Butacaine Sulphate
• 中文别名: 硫酸布他卡因
• 英文别名: 3-(dibutylamino)propyl 4-aminobenzoate,sulfuric acid; EINECS 205-733-1; MFCD00269938

物化性质

• 密度: 1.014g/cm3
• 沸点: 440ºC at 760mmHg
• 熔点: 155-157ºC
• 分子式: C₃₆H₆₂N₄O₈S
• 分子量: 710.96400
• 闪点: 219.9ºC
• 精确质量: 710.42900
• PSA: 194.10000
• LogP: 9.02620
• 外观性状: 灰白色固体
• 蒸汽压: 6.1E-08mmHg at 25°C
• 储存条件:

  通风低温干燥处。

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:4

  3.氢键受体数量:12

  4.可旋转化学键数量:24

  5.互变异构体数量:6

  6.拓扑分子极性表面积194

  7.重原子数量:49

  8.表面电荷:0

  9.复杂度:362

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:3

• 更多:

  1.熔点（℃）：155-157。

毒性和生态

毒理学数据: 腹腔-小鼠 LD50:80 毫克/公斤; 静脉-小鼠 LD50: 12 毫克/公斤。 CHEMICAL IDENTIFICATION RTECS NUMBER : UB1050000 CAS REGISTRY NUMBER : 149-15-5 LAST UPDATED : 199404 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C36-H60-N4-O4.H2-O4-S MOLECULAR WEIGHT : 711.08 WISWESSER LINE NOTATION : ZR DVO3N4&4 2 &WSQQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 197 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 1,90,1946 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 24,167,1925 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 12 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 40,373,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81742 No. of Facilities: 5 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 16 (estimated)

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 20/21/22-36/37/38.
• 安全声明 (欧洲): S26;S36
• 危险品运输编码: UN 3249
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2922499990

海关

海关编码	2922499990
中文概述	2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%