162204-20-8

• 常用中文名：5'-脱氧-5-氟-N-[(戊氧基)羰基]胞苷 2',3'-二乙酸酯
• 常用英文名：5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate
• CAS号：162204-20-8
• 分子式：C₁₉H₂₆FN₃O₈
• 分子量：443.423
• 发布时间：2018-08-03 08:57:01
• 更新时间：2026-07-22 18:07:15

名称

• 中文名: 5'-脱氧-5-氟-N-[(戊氧基)羰基]胞苷 2',3'-二乙酸酯
• 英文名: 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate
• 中文别名: (2Β,3Α,5Α,16Β,17Β)-2-(4-吗啉基)-16-(1-吡咯烷基)-雄甾烷-3,17-二醇; 5'-脱氧-5-氟-N-[(戊氧基)羰基]胞苷 2',3'-二乙酸酯(卡培他滨中间体); 卡培他滨的中间体; 2',3'-二-O-乙酰基-5'-脱氧-5-氟-N-(戊氧基羰基)胞苷; 2',3'-二-O-乙酰基-5'-脱氧-5-氟-N 4 - (戊氧基羰基) - 组氨酸; (2R,3R,4R,5R)-2-(5-氟-2-氧代-4-(((戊氧基)羰基)氨基)嘧啶-1(2H)-基)-5-甲基四氢呋喃-3,4-二基二乙酸酯; 3'-二乙酸酯; 2',3'-二-O-乙酰基-5'-脱氧-5-氟-N4-正戊氧羰基胞苷; 5-脱氧-2,3-二-O-乙酰基-N4【(正戊氧基)羰基】-5-氟胞苷; 5'-脱氧-5-氟-N-[(戊氧基)羰基]胞嘧啶核苷-2',3'-二乙酸酯; 2,3-二-O-乙酰卡培他滨; 脱氧-5-氟-N-[(戊氧基)羰基]胞苷 2',3'-二乙酸酯(卡培他滨中间体; 5'-脱氧-5-氟-N-[(戊; 5'-脱氧-5-氟-N-[(戊氧基)羰基]胞嘧啶2',3'-二醋酸盐; 2',3'-二-O-乙酰基-5'-脱氧-5-氟-N4-(戊氧羧基)胞苷; 5′-脱氧-5-氟-N-[(戊氧基)羰基]胞苷2′,3′-二乙酸脂; 卡培他滨中间体Cap-6; 5'-脱氧-2',3'-二-O-乙酰基-N4-[(正戊氧基)羰基]-5-氟胞苷; 卡培他滨杂质7(卡培他滨杂质G); 卡培他宾中间体3/5'-脱氧-5-氟-N-[(戊氧基)羰基]胞苷 2',3'-二乙酸酯; 卡培他滨中间体1; 5-脱氧-5-氟-N-[(戊氧基)羰基]胞苷2; 卡培他滨杂质G; 2',3'-二-O-乙酰基-5'-脱氧-5-氟-N4-(戊氧酰基)胞苷; 5'-脱氧-2',3'-二-O-乙酰基-N4-[(二正戊氧基)羰基]-5-氟胞苷; 卡培他滨中间体3; 5-溴-4-氯-3-吲哚-Α-D-N-乙酰神经氨酸钠盐; 卡培他滨中间体-A-09; 卡培他宾中间体,5'-脱氧-5-氟-N-[(戊氧基)羰基]胞苷 2',3'-二乙酸酯; (2R,3R,4R,5R)-2-(5-氟-2-氧代-4-(((戊基氧基)羰基)氨基)嘧啶-1-(2H)-基)-5-甲基四氢呋喃-3,4-二基二乙酸酯; 卡培他滨杂质J; 卡六)
• 英文别名: Capecitabine Intermediate-3; 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diacetate; carbonyl]cytidine 2',3'-diacetate; Capecitabine interMediate; Pentyl [1-(2,3-Di-O-acetyl-5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]ca; Pentyl [1-(2,3-Di-O-acetyl-5-deoxy-beta-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]cbamate; 5`-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2`,3`-diacetate; Capecitabine Impurity 7(Capecitabine Impurity G); ICytidine,5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-, 2',3'-diacetate; 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine; 2',3'-Di-O-acetylcapecitabine; Capecitabine Impurity 7; 5'- deoxy -5- fluoro -N-[ (pentoxy) carbonyl] cytidine 2',3'- diacetate; Capecitabine 2',3'-diacetate; [1-(2,3-Di-O-acetyl-5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyriMidinyl]cbaMic Acid Pentyl Ester; 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-N4-(pentoxycboxyl)cytidine; dihydro-2-oxo-4-pyrimidinyl]-, pentylester; 5'-Deoxy-5-fluoro-N-[(pentyloxy); 5'-deoxy-5-fluore-N-[(pentyloxy) carbonyl] cytidine 2',3'-diacetate; Capecitabine Impurity 2; 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2',3'-diac; 5''-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine 2'',3''-diacetate; Capecitabine Intermediate 1; T6NVNJ DMVO5 EF A- BT5OTJ COV1 DOV1 E1 &&Ribo-β-D Form; 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-N-(pentyloxycbonyl)cytidine; 5'-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2',3'-diacetate; 5'-deoxi-5-fluoro-N-(pentyloxy)carbonyl cytidine-2',3'- diacetate; Capecitabine Impurity G; uoro-N-[(pentyL; [(2R,3R,4R,5R)-4-acetyloxy-5-[5-fluoro-2-oxo-4-(pentoxycarbonylamino)pyrimidin-1-yl]-2-methyloxolan-3-yl] acetate; 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-N4-(pentoxycbonxyl)cytidine; Cytidine, 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-, 2',3'-diacetate; 2', 3'-Di-O-acetyl-5'-Deoxy-5-Fuluro-N4-(Pentoxycbonxyl)-Cytidine; 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-N-(pentoxycboxyl)cytidine; 5'Deoxy5fluoroN[(pentyloxy)carbonyl]cytidine 2',3'diacetate,5' Deoxy 5 fluoro N [(pentyloxy)carbonyl]cytidine 2',3' diacetate; ]cytidine 2',3'-diacetate; Capecitabine impurity J; 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-, 2',3'-diacetate; 5'-Deoxy-5-fL; 5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-, 2',3'-diacetate 5'; Capecitabine-7; Cytidine,5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-, 2',3'-diacetate; Capecitabin iMpurity J; (2R,3R,4R,5R)-2-(5-fluoro-2-oxo-4-(((pentyloxy)carbonyl)amino)pyriMidin-1(2H)-yl)-5-Methyltetrahydrofuran-3,4-diyl diacetate; 2', 3'-Di-O-acetyl-5'-Deoxy-5-F-N4-(Pentoxycbonxyl)-Cytidine

物化性质

• 密度: 1.4±0.1 g/cm3
• 熔点: 111 °C
• 分子式: C₁₉H₂₆FN₃O₈
• 分子量: 443.423
• 精确质量: 443.170380
• PSA: 135.05000
• LogP: 2.14
• 外观性状: 固体;White to Almost white powder to crystal
• 折射率: 1.567
• 储存条件: 0-10°C;存放于惰性气体之中;避免空气,加热
• 水溶解性: 可溶于：甲醇

安全

• 危害码 (欧洲): Xi
• 海关编码: 2934999090

合成路线

37076-71-4 862508-03-0 ~28% 162204-20-8

文献：Coll Farma S.L. Patent: EP2241556 A1, 2010 ; Location in patent: Page/Page column 9 ;

638-41-5 161599-46-8 ~% 162204-20-8

文献：Shimma, Nobuo; Umeda, Isao; Arasaki, Motohiro; Murasaki, Chikako; Masubuchi, Kazunao; Kohchi, Yasunori; Miwa, Masanori; Ura, Masako; Sawada, Noriaki; Tahara, Hitoshi; Kuruma, Isamu; Horii, Ikuo; Ishitsuka, Hideo Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 7 p. 1697 - 1706

1071455-34-9 27821-07-4 ~% 162204-20-8

文献：Organic Letters, , vol. 14, # 13 p. 3348 - 3351

638-41-5 41108-04-7 27821-07-4 ~% 162204-20-8

文献：Organic Letters, , vol. 14, # 13 p. 3348 - 3351

638-41-5 ~% 162204-20-8

文献：Organic Letters, , vol. 14, # 13 p. 3348 - 3351

27821-07-4 ~% 162204-20-8

文献：Bioorganic and Medicinal Chemistry, , vol. 8, # 7 p. 1697 - 1706

上下游产品

上游产品  6
37076-71-4 862508-03-0 638-41-5 161599-46-8
27821-07-4 41108-04-7
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154361-50-9

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%