118457-16-2

• 常用中文名：(1S)-1-[(2S)-6-氟色满-2-基]-2-[[(2S)-2-[(2S)-6-氟色满-2-基]-2-羟基乙基]氨基]乙醇
• 常用英文名：(1S)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol
• CAS号：118457-16-2
• 分子式：C₂₂H₂₅F₂NO₄
• 分子量：405.43500
• 发布时间：2016-02-29 03:54:50
• 更新时间：2026-07-05 12:52:23

名称

• 中文名: (-)-奈必洛尔
• 英文名: (1S)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol
• 中文别名: 奈必洛尔杂质2; 奈比洛尔杂质A; 奈比诺尔杂质对照品; 奈必洛尔杂质A; 奈必洛尔杂质42(L-奈必洛尔)(RS,SS); 奈比洛尔杂质(L-奈必洛尔); 奈比洛尔杂质1(L-奈比洛尔); L-奈必洛尔 (RS,SS)
• 英文别名: (S)-1-((R)-6-fluorochroman-2-yl)-2-(((S)-2-((S)-6-fluorochroman-2-yl)-2-hydroxyethyl)amino)ethanol; L-Nebivolol (RS,SS)-d6 HCl; Nebivolol Impurity A (L-Nebivolol) (RS,SS) HCl; [2R,2'S,αS,α'S,(-)]-α,α'-[Iminobis(methylene)]bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol); R-67145; UNII-GMK2E335DQ; (R,S,S,S)-nebivolol; (aS,a,2R,2)-a,a[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]; Nebivolol Impurity A; Nebilolol impurity 24; ()-Nebivolol; (αS,α'S,2R,2'S)-α,α'-[IMinobis(Methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-Methanol]; Levonebivolol; [2S-[2R*[R*[R*(S*)]]]]-α,α'-[IMinobis(Methylene)]bis[6-fluoro-3,4-dihydro- 2H-1-benzopyran-2-Methanol; l-Nebivolol; Nebivolol Desfluoro impurity; Nebivolol Impurity AQ: What is Nebivolol Impurity A Q: What is the CAS Number of Nebivolol Impurity A Q: What is the storage condition of Nebivolol Impurity A Q: What e the applications of Nebivolol Impurity A; Nebivolol Impurity A (L-Nebivolol); Nebivolol Impurity; l-nebivolol; L-Nebivolol (RS,SS); 2H-1-Benzopyran-2-methanol, α,α'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-, (αS,α'S,2R,2'S); (2R)-2-[(S)-1-Hydroxy-2-[[(S)-2-hydroxy-2-[[(2S)-3,4-dihydro-6-fluoro-2H-1-benzopyran]-2-yl]ethyl]amino]ethyl]-6-fluoro-3,4-dihydro-2H-1-benzopyran; L-Nebivolo; (aS,a’S,2R,2’S)-a,a’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]; Nebivolol Impurity 42 (L-Nebivolol) (RS,SS)

物化性质

• 密度: 1.309g/cm3
• 沸点: 600.5ºC at 760mmHg
• 分子式: C₂₂H₂₅F₂NO₄
• 分子量: 405.43500
• 闪点: 316.9ºC
• 精确质量: 405.17500
• PSA: 70.95000
• LogP: 2.75450
• 蒸汽压: 2.88E-15mmHg at 25°C
• 折射率: 1.58

合成路线

682359-63-3 ~60% 118457-16-2

文献：EGIS GYOGYSZERGYAR RT. Patent: WO2004/41805 A1, 2004 ; Location in patent: Page 68-69 ;

1224567-85-4 ~65% 118457-16-2

文献：ZACH SYSTEM S.P.A.; MARAGNI, Paolo; MICHIELETTO, Ivan; VOLPICELLI, Raffaella; SORIATO, Giorgio; FOLETTO, Johnny; COTARCA, Livius; VERZINI, Massimo Patent: WO2010/49455 A1, 2010 ; Location in patent: Page/Page column 10-11 ;

129050-23-3 905454-41-3 ~% 118457-16-2

文献：WO2008/64826 A1, ; Page/Page column 26-27 ;

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