CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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GU6780000
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CHEMICAL NAME :
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Cyclohexaneacetic acid, alpha-phenyl-, 2-(diethylamino)ethyl ester
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CAS REGISTRY NUMBER :
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1679-76-1
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BEILSTEIN REFERENCE NO. :
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2059173
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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6
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MOLECULAR FORMULA :
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C20-H31-N-O2
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MOLECULAR WEIGHT :
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317.52
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WISWESSER LINE NOTATION :
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L6TJ AYR&VO2N2&2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1600 mg/kg
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TOXIC EFFECTS :
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Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - ulceration or bleeding from stomach
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REFERENCE :
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APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam, Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ. Volume(issue)/page/year: 1,4,1950
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1600 mg/kg
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TOXIC EFFECTS :
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Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
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REFERENCE :
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APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam, Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ. Volume(issue)/page/year: 1,4,1950
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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37 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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AJDDAL American Journal of Digestive Diseases. (New York, NY) V.5-22, 1938-55; New series: V.1-23, 1956-78. For publisher information, see DDSCDJ. Volume(issue)/page/year: 18,241,1951
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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500 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness
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REFERENCE :
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BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 14,559,1959
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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>200 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam, Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ. Volume(issue)/page/year: 1,4,1950
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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40 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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APPNAH Acta Physiologica et Pharmacologica Neerlandica. (Amsterdam, Netherlands) V.1-15, 1950-69. For publisher information, see EJPHAZ. Volume(issue)/page/year: 1,4,1950
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