24356-94-3

• 常用中文名：苯甲孕酮
• 常用英文名：Algestone acetophenide
• CAS号：24356-94-3
• 分子式：C₂₉H₃₆O₄
• 分子量：448.594
• 相关类别： 研究领域 代谢疾病
• 发布时间：2018-08-17 07:50:31
• 更新时间：2024-01-06 14:23:08
• Algestone acetophenide 是一种黄体酮药物。Algestone acetophenide 能与雌激素联合使用,作为一种长效注射避孕药。

名称

• 中文名: 苯甲孕酮
• 英文名: algestone acetophenide
• 中文别名: 阿尔孕酮乙酰苯环缩酮; 16alpha,17alpha-二羟基孕甾-4-烯-3,20-二酮-16,17-苯乙酮缩酮; 16α,17α-二羟基-孕甾-4-烯-3,20-二酮-16,17-苯乙酮缩酮
• 英文别名: Algestone acetophenide; Bovitrol; (4aR,4bS,6aS,6bS,8R,9aR,10aS,10bR)-6b-Acetyl-4a,6a,8-trimethyl-8-phenyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; 16α,17α-Dihydroxyprogesterone acetophenide; 2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 6b-acetyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-4a,6a,8-trimethyl-8-phenyl-, (4aR,4bS,6aS,6bS,8R,9aR,10aS,10bR)-; Algestone acetophonide; 16a,17-Dihydroxypregn-4-ene-3,20-dione Cyclic Acetal with Acetophenone; Droxone; UNII:T379IG5RV1; [16a(R)]-16,17-[(1-Phenylethylidene)bis(oxy)]pregn-4-ene-3,20-dione; MFCD00056835; Neolutin Depositum; EINECS 246-195-8; Dihydroxyprogesterone acetophenide; P-Dhp; 2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 6b-acetyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-4a,6a,8-trimethyl-8-phenyl-, (4aR,4bS,6aS,6bS,9aR,10aS,10bR)-; deladroxone; 16a,17a-Dihydroxyprogesterone Acetophenide; ALGESTERONE ACETOPHENIDE; (4aR,4bS,6aS,6bS,9aR,10aS,10bR)-6b-Acetyl-4a,6a,8-trimethyl-8-phenyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one; alphasoneacetophenide

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 579.0±50.0 °C at 760 mmHg
• 熔点: 150 - 151ºC
• 分子式: C₂₉H₃₆O₄
• 分子量: 448.594
• 闪点: 246.7±30.2 °C
• 精确质量: 448.261353
• PSA: 52.60000
• LogP: 6.16
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.591
• 储存条件: 室温

生物活性

• 描述: Algestone acetophenide 是一种黄体酮药物。Algestone acetophenide 能与雌激素联合使用,作为一种长效注射避孕药。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Daeseleire, et al. Application of high-performance thin-layer chromatography and gas chromatography-mass spectrometry to the detection of new anabolic steroids used as growth promoters in cattle fattening. Journal of Chromatography A. 1994;674(1-2): 247–253.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU5011700 CHEMICAL NAME : Pregn-4-ene-3,20-dione, 16-alpha,17-dihydroxy-, cyclic acetal with acetophenone, (R)- CAS REGISTRY NUMBER : 24356-94-3 LAST UPDATED : 198910 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C29-H36-O4 MOLECULAR WEIGHT : 448.65 WISWESSER LINE NOTATION : T F5 E5 B666 GO IO RV PUTJ A1 E1 FV1 H1 HR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 250 mg/kg SEX/DURATION : female 10 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 2500 mg/kg SEX/DURATION : female 20 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 750 mg/kg SEX/DURATION : female 10 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin DOSE : 240 mg/kg SEX/DURATION : male 30 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 10,687,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 300 mg/kg SEX/DURATION : female 14-19 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 71,448,1962 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 100 mg/kg SEX/DURATION : female 20 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 2250 ug/kg SEX/DURATION : female 15 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 100 mg/kg SEX/DURATION : female 20 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 15,63,1964 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 79200 ug/kg SEX/DURATION : male 48 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) REFERENCE : STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 8,33,1966 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 396 mg/kg SEX/DURATION : male 48 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) REFERENCE : STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 8,33,1966 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 700 mg/kg SEX/DURATION : female 35 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 57,1475,1969 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 84 mg/kg SEX/DURATION : female 35 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) REFERENCE : IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 57,1475,1969

安全

• 危害码 (欧洲): Xi: Irritant;