33263-43-3

• 常用中文名：4-氯吡啶-3-磺酰胺
• 常用英文名：4-chlorpyridin-3-sulfonamid
• CAS号：33263-43-3
• 分子式：C₅H₅ClN₂O₂S
• 分子量：192.623
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 氯吡啶
• 发布时间：2018-02-09 08:00:00
• 更新时间：2024-01-02 11:42:11

• 1、 用于合成利尿药物托拉塞米(Torasemide)。

名称

• 中文名: 4-氯吡啶-3-磺酰胺
• 英文名: 4-Chloro-3-pyridinesulfonamide
• 中文别名: 4-氯-3-吡啶磺胺; 4-氯-3-氨-2-甲磺酰吡啶; 4-氯-3-吡啶磺酰胺
• 英文别名: 4-CHLORO-3-PYRIDINESULFAMIDE; 4-Chloropyridine-3-Sulfamide; 4-Choropyridine-3-sulphonamide. 4-chloro-3-pyridinesulfonamide; 4-Choropyridine; 4-chloro-pyridine-3-sulphonamide; EINECS 251-434-4; 4-Chloropyridin-3-sulfonamide; 4-Chloropyridine-3-sulfonamide; 4-chlorpyridin-3-sulfonamid; 4-CHOROPYRIDINE-3-SULPHONAMIDE; 4-Chloropyridine-sulphonamide; MFCD03093286; 4-chloro-pyridine-3-sulfonic acid amide; 3-Pyridinesulfonamide, 4-chloro-; 4-chloropyridin-3-yl-sulfonamide; 3-PYRIDINE-4-CHLOROSULFONAMIDE; 4-Chloro-3-Sulfamoylpyridine; 4-Chloro-3-pyridinesulfonamide

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 380.4±52.0 °C at 760 mmHg
• 熔点: 150-155 °C
• 分子式: C₅H₅ClN₂O₂S
• 分子量: 192.623
• 闪点: 183.9±30.7 °C
• 精确质量: 191.976028
• PSA: 81.43000
• LogP: -0.28
• 外观性状: 灰白色至淡米色粉末
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.592
• 储存条件:

  保持贮藏器密封、储存在阴凉、干燥的地方，确保工作间有良好的通风或排气装置

• 稳定性:

  如果遵照规格使用和储存则不会分解，未有已知危险反应

  避免氧化物
• 水溶解性: soluble
• 计算化学:

  1.疏水参数计算参考值（XlogP）:0

  2.氢键供体数量:1

  3.氢键受体数量:4

  4.可旋转化学键数量:1

  5.互变异构体数量:无

  6.拓扑分子极性表面积81.4

  7.重原子数量:11

  8.表面电荷:0

  9.复杂度:223

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：无色至浅黄色结晶体粉末

  2. 密度（g/mL,20℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：150-154

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,KPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（Pa,20ºC）：未确定

  12. 饱和蒸气压（KPa,20ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：0

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：可溶于水

MSDS

Name: 4-Chloro-3-pyridinesulfonamide Material Safety Data Sheet Synonym: CAS: 33263-43-3 Section 1 - Chemical Product MSDS Name:4-Chloro-3-pyridinesulfonamide Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 33263-43-3 4-Chloro-3-pyridinesulfonamide 251-434-4 Hazard Symbols: XN Risk Phrases: 20/21/22 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Harmful by inhalation, in contact with skin and if swallowed. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Harmful if absorbed through the skin. Ingestion: Harmful if swallowed. May cause irritation of the digestive tract. Inhalation: Harmful if inhaled. May cause respiratory tract irritation. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: DO NOT USE WATER! Use dry powder or carbon dioxide. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 33263-43-3: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: off-white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Soluble. Specific Gravity/Density: Molecular Formula: C5H5ClN2O2S Molecular Weight: 192.5602 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials, excess heat. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Hydrogen cyanide, carbon monoxide, oxides of nitrogen, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 33263-43-3 unlisted. LD50/LC50: Not available. Carcinogenicity: 4-Chloro-3-pyridinesulfonamide - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Other No information available. Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. Safety Phrases: S 36/37 Wear suitable protective clothing and gloves. WGK (Water Danger/Protection) CAS# 33263-43-3: 1 Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 33263-43-3 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 33263-43-3 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 通常对水是稍微有危害的，若无政府许可，勿将材料排入周围环境。

安全

• 危害码 (欧洲): Xn:Harmful;
• 风险声明 (欧洲): R22;R36/37/38
• 安全声明 (欧洲): S36/37
• 危险品运输编码: 2811
• 包装等级: III
• 海关编码: 2935009090

上下游产品

上游产品  3
33263-44-4 51498-37-4 626-64-2
下游产品  7
56211-40-6 72811-73-5 75903-62-7 160822-47-9
76287-10-0 58155-57-0 38030-43-2

海关

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%