4076-02-2

• 常用中文名：2,3-二巯基丙磺酸钠
• 常用英文名：unithiol
• CAS号：4076-02-2
• 分子式：C₃H₇NaO₃S₃
• 分子量：210.271
• 相关类别： 原料药 专科用药 解毒药
• 发布时间：2018-06-27 12:28:44
• 更新时间：2024-01-02 11:04:27

• 橡胶和制药工业。重金属中毒解毒剂。

名称

• 中文名: 2,3-二巯基丙磺酸钠
• 英文名: Sodium 2,3-dimercapto-1-propanesulfonate
• 中文别名: 2,3-二巯基丙烷磺酸钠盐; 解砷灵; 2,3-二氯-5-甲酰基吡啶; DL-2,3-二巯基-1-丙磺酸钠; 2,3-二巯基-1-丙烷磺酸 钠盐
• 英文别名: 2,3-Dimercaptopropylsulphonica; Dimaval; DIMERCAPTOPROPANESULPHONICACID; unitiol; Sodium 2,3-disulfanyl-1-propanesulfonate; 2,3-DICHLORO-5-FORMYLPYRIDINE; 2,3-dimercaptopropane-1-sulfonic acid sodium salt; EINECS 223-796-3; MFCD00007523; 1-Propanesulfonic acid, 2,3-dimercapto-, monosodium salt; sodium 2,3-disulfanylpropane-1-sulfonate; SodiumDimercaptopropanesulfonate; unithiol; sodium 2,3-mercapto-1-propanesulfonate; antidote; Unithiolum; 1-Propanesulfonic acid, 2,3-dimercapto-, sodium salt (1:1); sodium 2,3-dimercaptopropane-1-sulfonate; UNII:690VN2L7TK; 2,3-sulfonate; 2,3-DIMERCAPTOPROPANESULPHONATE

物化性质

• 熔点: 215 °C (dec.)
• 分子式: C₃H₇NaO₃S₃
• 分子量: 210.271
• 精确质量: 209.945496
• PSA: 143.18000
• LogP: 0.84060
• 外观性状: 白色粉末
• 储存条件:

  避光，通风干燥处，密封保存

• 稳定性:

  常温常压下稳定，白色叶状结晶。易溶于水，不溶于乙醇。熔点235℃。半数致死量（小鼠，腹腔）5.22mmol/kg。市售商品中也有含1分子结晶水的产品。

• 水溶解性: H2O: 0.1 g/mL, clear
• 分子结构:

  1、摩尔折射率：无可用的

  2、摩尔体积（cm³/mol）：无可用的

  3、等张比容（90.2K）：无可用的

  4、表面张力（dyne/cm）：无可用的

  5、介电常数：无可用的

  6、极化率（10^-24cm³）：无可用的

  7、单一同位素质量：209.945499Da

  8、标称质量：210Da

  9、平均质量：210.2706Da

MSDS

Name: Dl-2 3-Dimercapto-1-Propanesulfonic Acid Sodium Salt Monohydrate Material Safety Data Sheet Synonym: DMP CAS: 4076-02-2 Section 1 - Chemical Product MSDS Name:Dl-2 3-Dimercapto-1-Propanesulfonic Acid Sodium Salt Monohydrate Material Safety Data Sheet Synonym:DMP Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 4076-02-2 DI-2,3-Dimercapto-1-Propanesulfonic Ac 95% 223-796-3 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Air sensitive.The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: No information regarding eye irritation and other potential effects was found. Skin: No information regarding skin irritation and other potential effects was found. Ingestion: The toxicological properties of this substance have not been fully investigated. Inhalation: The toxicological properties of this substance have not been fully investigated. Inhalation of dust may cause respiratory tract irritation. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use agent most appropriate to extinguish fire. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use only in a well-ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Storage: Store in a cool, dry place. Keep container closed when not in use. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 4076-02-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white Odor: None reported. pH: 5.0 0.5 Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: @ 760.00mm Hg Freezing/Melting Point: 229 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C3H7O3S3Na.H2O Molecular Weight: 228.28 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Not available. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, oxides of sulfur, carbon dioxide, sodium oxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 4076-02-2: TZ6420000 LD50/LC50: Not available. Carcinogenicity: DI-2,3-Dimercapto-1-Propanesulfonic Acid, Sodium Salt Monohydrate - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 4076-02-2: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 4076-02-2 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 4076-02-2 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 通常对水是不危害的，若无政府许可，勿将材料排入周围环境。 CHEMICAL IDENTIFICATION RTECS NUMBER : TZ6420000 CHEMICAL NAME : 1-Propanesulfonic acid, 2,3-dimercapto-, monosodium salt CAS REGISTRY NUMBER : 4076-02-2 LAST UPDATED : 199309 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C3-H7-O3-S3.Na MOLECULAR WEIGHT : 210.27 WISWESSER LINE NOTATION : WSO&1YSH1SH &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1055 mg/kg TOXIC EFFECTS : Behavioral - excitement Behavioral - withdrawal Skin and Appendages - dermatitis, other (after systemic exposure) TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1098 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 22709 mg/kg/36W-I TOXIC EFFECTS : Nutritional and Gross Metabolic - changes in metals, not otherwise specified TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 8190 mg/kg/26W-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in metals, not otherwise specified TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 105 gm/kg/10W-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in metals, not otherwise specified Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 10500 mg/kg/10W-I TOXIC EFFECTS : Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - changes in metals, not otherwise specified Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 2730 mg/kg/26W-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 28 gm/kg SEX/DURATION : female 26 week(s) pre-mating - 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 750 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - other developmental abnormalities MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 1 mmol/L REFERENCE : CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 8(4),31,1974

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S24/25
• WGK德国: 3
• RTECS号: TZ6420000
• 海关编码: 2930909090

海关

海关编码	2930909090
中文概述	2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%