576-68-1

• 常用中文名：甘露醇氮芥
• 常用英文名：mannomustine
• CAS号：576-68-1
• 分子式：C₁₀H₂₂Cl₂N₂O₄
• 分子量：305.19900
• 相关类别： 原料药 抗肿瘤药 烷化剂类抗肿瘤药
• 发布时间：2018-08-02 16:46:59
• 更新时间：2024-01-16 01:05:37

名称

• 中文名: 甘露醇氮芥
• 英文名: (2R,3R,4R,5R)-1,6-bis(2-chloroethylamino)hexane-2,3,4,5-tetrol
• 中文别名: 甘露莫司汀
• 英文别名: Mannit-lost [German]; Mannomustin; Mannitol nitrogen mustard; Manomustina [INN-Spanish]; Mannomustine [INN:BAN:DCF]; Mannit-mustard [German]; Mannit-Lost; Mannomustinum [INN-Latin]; 1,6-Bis-<(2-chlorethyl)-amino>-1,6-dideoxy-D-mannitol; 1,6-Bis-(2-chlor-aethylamino)-1,6-didesoxy-D-mannit; BCM (cytostatic); mannomustine; 1,6-bis-(2-chloro-ethylamino)-1,6-dideoxy-D-mannitol; 1,6-Bis-<2-chlor-ethylamino>-1,6-didesoxy-D-mannit

物化性质

• 密度: 1.353g/cm3
• 沸点: 541.9ºC at 760 mmHg
• 熔点: 278°C (rough estimate)
• 分子式: C₁₀H₂₂Cl₂N₂O₄
• 分子量: 305.19900
• 闪点: 281.5ºC
• 精确质量: 304.09600
• PSA: 104.98000
• 折射率: 1.544

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : OP2100000 CHEMICAL NAME : Mannitol, 1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-, D-, CAS REGISTRY NUMBER : 576-68-1 LAST UPDATED : 199707 DATA ITEMS CITED : 13 MOLECULAR FORMULA : C10-H22-Cl2-N2-O4 MOLECULAR WEIGHT : 305.24 WISWESSER LINE NOTATION : G2M1YQYQYQYQ1M2G -D HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Tumorigenic - protects against induction of experimental tumors TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Blood - leukopenia TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Sister chromatid exchange MUTATION DATA TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Cells - not otherwise specified DOSE/DURATION : 2900 nmol/L REFERENCE : SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 18,210,1982

合成路线

16658-08-5 ~% 576-68-1

文献：Vargha et al. Journal of the Chemical Society, 1957 , p. 805,809

108991-70-4 ~% 576-68-1

文献：Vargha et al. Journal of the Chemical Society, 1957 , p. 805,809

7465-84-1 ~% 576-68-1

文献：Vargha et al. Journal of the Chemical Society, 1957 , p. 805,809

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