20168-99-4

• 常用中文名：桂美辛
• 常用英文名：1H-Indole-3-aceticacid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-
• CAS号：20168-99-4
• 分子式：C₂₁H₁₉NO₄
• 分子量：349.38000
• 相关类别： 原料药 解热镇痛药 非甾抗炎药
• 发布时间：2018-04-30 08:00:00
• 更新时间：2025-08-21 17:01:33

名称

• 中文名: 桂美辛
• 英文名: cinmetacin
• 英文别名: 5-Methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)-1H-indole-3-acetic acid; 1-cinnamoyl-5-methoxy-2-methyl-1-indole-3-acetic acid; 1-Cinnamoyl-5-methoxy-2-methyl-indol-3-yl-essigsaeure; Cindomet; (1-Cinnamoyl-5-methoxy-2-methyl-3-indolyl)-essigsaeure; cinmethacin; [5-methoxy-2-methyl-1-(3-phenyl-acryloyl)-indol-3-yl]-acetic acid; Indolacin; 1-(1-Oxo-3-phenyl-2-propenyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid

物化性质

• 密度: 1.19g/cm3
• 沸点: 488ºC at 760mmHg
• 熔点: 170-172°; mp 164-165°
• 分子式: C₂₁H₁₉NO₄
• 分子量: 349.38000
• 闪点: 248.9ºC
• 精确质量: 349.13100
• PSA: 68.53000
• LogP: 3.93900
• 蒸汽压: 2.45E-10mmHg at 25°C
• 折射率: 1.593

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NL3523000 CHEMICAL NAME : Indole-3-acetic acid, 1-cinnamoyl-5-methoxy-2-methyl- CAS REGISTRY NUMBER : 20168-99-4 LAST UPDATED : 198702 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C21-H19-N-O4 MOLECULAR WEIGHT : 349.41 WISWESSER LINE NOTATION : T56 BNJ BV1U1R& C1 D1VQ GO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 900 mg/kg TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - peritonitis REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,397,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 590 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1690,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 685 mg/kg TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - peritonitis REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,397,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 360 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1690,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 540 mg/kg TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - peritonitis REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,397,1979

安全

• 海关编码: 2933990090

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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%