Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1H-Indole-3-aceticacid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang

20168-99-4

20168-99-4 structure

20168-99-4 structure

Name: 1H-Indole-3-aceticacid, 5-methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propen-1-yl)-
Chemical Name: cinmetacin
CAS Number: 20168-99-4
Molecular Formula: C₂₁H₁₉NO₄
Molecular Weight: 349.38000
Catalog: API Antipyretic analgesics Non-steroidal anti-inflammatory drugs
Create Date: 2018-04-30 08:00:00
Modify Date: 2024-01-10 08:18:15

Name	cinmetacin
Synonyms	5-Methoxy-2-methyl-1-(1-oxo-3-phenyl-2-propenyl)-1H-indole-3-acetic acid 1-cinnamoyl-5-methoxy-2-methyl-1-indole-3-acetic acid 1-Cinnamoyl-5-methoxy-2-methyl-indol-3-yl-essigsaeure Cindomet (1-Cinnamoyl-5-methoxy-2-methyl-3-indolyl)-essigsaeure cinmethacin [5-methoxy-2-methyl-1-(3-phenyl-acryloyl)-indol-3-yl]-acetic acid Indolacin 1-(1-Oxo-3-phenyl-2-propenyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid

Density	1.19g/cm3
Boiling Point	488ºC at 760mmHg
Melting Point	170-172°; mp 164-165°
Molecular Formula	C₂₁H₁₉NO₄
Molecular Weight	349.38000
Flash Point	248.9ºC
Exact Mass	349.13100
PSA	68.53000
LogP	3.93900
Vapour Pressure	2.45E-10mmHg at 25°C
Index of Refraction	1.593

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL3523000

CHEMICAL NAME :: Indole-3-acetic acid, 1-cinnamoyl-5-methoxy-2-methyl-

CAS REGISTRY NUMBER :: 20168-99-4

LAST UPDATED :: 198702

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C21-H19-N-O4

MOLECULAR WEIGHT :: 349.41

WISWESSER LINE NOTATION :: T56 BNJ BV1U1R& C1 D1VQ GO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - peritonitis

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,397,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 590 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1690,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 685 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - peritonitis

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,397,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1690,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - peritonitis

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 15,397,1979

HS Code	2933990090

Precursor 0
DownStream 2
2882-15-7 4151-45-5

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%