65057-90-1

• 常用中文名：他利霉素
• 常用英文名：Bleomycinamide,N1-[4-amino-6-[[3-[(4-aminobutyl)amino]propyl]amino]-6-oxohexyl]-13-[(4-amino-4,6-dideoxy-a-L-talopyranosyl)oxy]-19-demethyl-12-hydroxy-
• CAS号：65057-90-1
• 分子式：C₆₈H₁₁₀N₂₂O₂₇S₂
• 分子量：1731.86000
• 发布时间：2018-07-23 18:22:07
• 更新时间：2024-01-14 00:39:15

名称

• 中文名: 他利霉素
• 英文名: Talisomycin
• 英文别名: Antibiotic BU-2231A; Tallysomycin A; Bu-2231A

物化性质

• 密度: 1.58g/cm3
• 分子式: C₆₈H₁₁₀N₂₂O₂₇S₂
• 分子量: 1731.86000
• 精确质量: 1730.74000
• PSA: 881.89000
• 折射率: 1.686

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EC5990300 CHEMICAL NAME : Bleomycinamide, N(sup 1)-(4-amino-6-((3-((4-aminobutyl)amino)propyl)amino)- 6-oxohexyl)- 13-((4-amino-4,6-dideoxy-alpha-L-talopyranosyl)oxy)-1 9-demethyl-12-hydroxy- CAS REGISTRY NUMBER : 65057-90-1 LAST UPDATED : 199512 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C68-H110-N22-O27-S2 MOLECULAR WEIGHT : 1732.12 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 19 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain Tumorigenic - active as anti-cancer agent TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 17 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 40 mg/kg/4W-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - fibrosis (interstitial) MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 100 ug/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 113,288,1983