3771-19-5

• 常用中文名：萘酚平
• 常用英文名：Nafenopin
• CAS号：3771-19-5
• 分子式：C₂₀H₂₂O₃
• 分子量：310.38700
• 相关类别： 原料药 循环系统用药 调节血脂药
• 发布时间：2018-02-15 08:00:00
• 更新时间：2024-01-11 11:58:35

名称

• 中文名: 萘酚平
• 英文名: 2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid
• 英文别名: dl-Nafenopin; Nafenopino [INN-Spanish]; Melipan; 2-methyl-2-(p-(1,2,3,4-tetrahydro-naphthyl)phenoxy) propionic acid; Nafenopin; 2-methyl-2[p-(1,2,3,4-tetrahydro-1-naphthyl)phenoxy]propionic acid; Nafenoic acid; TPIA; Nafenopinum [INN-Latin]; Nafenopine [INN-French]

物化性质

• 密度: 1.155g/cm3
• 沸点: 466.4ºC at 760mmHg
• 分子式: C₂₀H₂₂O₃
• 分子量: 310.38700
• 闪点: 164.4ºC
• 精确质量: 310.15700
• PSA: 46.53000
• LogP: 4.39680
• 折射率: 1.581
• 储存条件: 室温，干燥，密封

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UF6125000 CHEMICAL NAME : Propionic acid, 2-methyl-2-(p-(1,2,3,4-tetrahydro-1-naphthyl)phenoxy) - CAS REGISTRY NUMBER : 3771-19-5 LAST UPDATED : 199612 DATA ITEMS CITED : 21 MOLECULAR FORMULA : C20-H22-O3 MOLECULAR WEIGHT : 310.42 WISWESSER LINE NOTATION : L66&TJ GR DOX1&1&VQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 39 gm/kg/92W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 56 gm/kg/81W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 33 gm/kg/78W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 41300 mg/kg/59W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors TYPE OF TEST : Unscheduled DNA synthesis TYPE OF TEST : Unscheduled DNA synthesis TYPE OF TEST : DNA inhibition MUTATION DATA TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Primate - monkey Liver DOSE/DURATION : 10 mg/L REFERENCE : CBRPDS Cell Biology International Reports. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 12,1077,1988 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,125,1980 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,125,1980 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW APLMAS Archives of Pathology and Laboratory Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-5(2), 1926-28; V.100- 1976- Volume(issue)/page/year: 107,54,1983

安全

• 危害码 (欧洲): Xn
• 海关编码: 2918990090

合成路线

529-33-9 ~% 3771-19-5

文献：Bencze,W.L. et al. Tetrahedron, 1970 , vol. 26, p. 5407 - 5414

71-43-2 ~% 3771-19-5

文献：Bencze,W.L. et al. Tetrahedron, 1970 , vol. 26, p. 5407 - 5414

67-66-3 3771-17-3 67-64-1 ~% 3771-19-5

文献：Bencze,W.L. et al. Tetrahedron, 1970 , vol. 26, p. 5407 - 5414

上下游产品

上游产品  5
529-33-9 71-43-2 67-66-3 3771-17-3
67-64-1
下游产品  0

海关

海关编码	2918990090
中文概述	2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%