5511-98-8

• 常用中文名：地高辛杂质I
• 常用英文名：α-Acetyl Digoxin
• CAS号：5511-98-8
• 分子式：C₄₃H₆₆O₁₅
• 分子量：822.97500
• 相关类别： 生物化工 糖类化合物 寡糖
• 发布时间：2018-05-04 08:00:00
• 更新时间：2026-07-05 11:33:41

• 生化研究。强心药。

名称

• 中文名: α-乙酰基地高辛
• 英文名: α-Acetyl Digoxin
• 中文别名: A-乙酰地高辛; Α-乙酰地高辛; 乙酰地高辛
• 英文别名: 20,5BETA-CDENOLID-3BETA,12BETA,14BETA-TRIOL 3BETA-2,6-DIDEOXY-4-O-[2,6-DIDEOXY-4-O-(2,6-DIDEOXY-BETA-D-RIBOHEXOPYRANOSYL)-BETA-D-RIBOHEXOPYRANOSIDE]15'-ACETATE; Digoxigenin + zuckerkette wie bie acetyl-digitoxin A [german]; 3’’’-acetyldigoxin; Alpha-Acetyl Digoxin; Digoxin Impurity I; Digoxin Impurity 9(Digoxin Impurity I); EINECS 226-855-1; Cd-20(22)-enolide, 3-[(O-3-O-acetyl-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1-)-O-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1-)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3beta,5beta,12beta); acetyl-digoxin-alpha; a-Acetyldigoxin; acetate,alpha-digoxi; digoxin,3’’’-acetate; Cd-20(22)-enolide, 3-[(O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β); digoxigenin+zuckerkettewiebieacetyl-digitoxina; Cd-20(22)-enolide, 3-((o-3-o-acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-o-2,6-dideoxy-beta-D-ribo-hexopyranosyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta); 3'''-acetyldigoxin; Desglucolanatosid; ALPHA-ACETYLDIGOXIN; 3β-[[4-O-[4-O-(3-O-Acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyl]oxy]-12β,14-dihydroxy-5β-cd-20-enolide; desglucolanatosidec; digorida; 3β-[4-O-[4-O-(3-O-Acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl)-2,6-dideoxy-β-D-ribo-hexopyranosyl]-2,6-dideoxy-β-D-ribo-hexopyranosyloxy]-12β,14-dihydroxy-5β,14β-cda-20-enolide; ALPHA-ACETYLDIGOXIN //BP; 3β-[(3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-5β-cd-20-enolide (α-acetyldigoxin)

物化性质

• 密度: 1.35g/cm3
• 沸点: 935.6ºC at 760mmHg
• 熔点: 199-201ºC
• 分子式: C₄₃H₆₆O₁₅
• 分子量: 822.97500
• 闪点: 275.4ºC
• 精确质量: 822.44000
• PSA: 209.13000
• LogP: 2.78890
• 折射率: 1.591
• 储存条件:

  阴凉干燥保存。

• 更多:

  1. 性状：白色结晶。

  2. 密度（g/mL,25/4℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：225

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：+18.9

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：易溶于吡啶，微溶于甲醇及氯仿，极微溶于乙酸乙酯，不溶于水。

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : IH6300000 CHEMICAL NAME : Digoxin, acetate, alpha- CAS REGISTRY NUMBER : 5511-98-8 LAST UPDATED : 199512 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C43-H66-O15 MOLECULAR WEIGHT : 823.09 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,1,1966 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 230 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,1854,1972 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraduodenal SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 494 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1765,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 3300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,1,1966 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 1880 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 70,39,1974 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,187,1963 TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,54,1963

安全

• 危险品运输编码: UN 3249
• 包装等级: II
• 危险类别: 6.1(a)

上下游产品

上游产品  3
75-36-5 20830-75-5 17575-22-3
下游产品  3
5355-48-6 20830-75-5 1672-46-4