601-77-4

• 常用中文名：亚硝基二异丙胺
• 常用英文名：N-Isopropyl-N-nitroso-2-propanamine
• CAS号：601-77-4
• 分子式：C₆H₁₄N₂O
• 分子量：130.188
• 相关类别： 有机原料 氨基化合物 无环单胺、多胺及其衍生物和盐
• 发布时间：2018-02-12 08:00:00
• 更新时间：2024-01-05 00:49:57

名称

• 中文名: N-亚硝基二异丙胺
• 英文名: N,N-di(propan-2-yl)nitrous amide
• 中文别名: 亚硝基二异丙胺; N-硝基二异丙胺
• 英文别名: N-Isopropyl-N-nitrosopropan-2-amine; Diisopropyl-N-nitrosamine; Diisopropylnitrosamin; 2-Propanamine,N-(1-methylethyl)-N-nitroso; Nitrosodiisopropylamine; Diisopropylnitrosamine; N-nitrosodiisopropyl amine; 2-Propanamine, N- (1-methylethyl)-N-nitroso-; (i-propyl)2NNO; Diisopropylnitrosamin [German]; Diisopropylamine,N-nitroso; N-nitroso-N-(propan-2-yl)propan-2-amine; N-Isopropyl-N-nitroso-2-propanamine; 2-Propanamine, N-(1-methylethyl)-N-nitroso-

物化性质

• 密度: 0.9±0.1 g/cm3
• 沸点: 194.5±0.0 °C at 760 mmHg
• 熔点: >300ºC
• 分子式: C₆H₁₄N₂O
• 分子量: 130.188
• 闪点: 73.6±18.7 °C
• 精确质量: 130.110611
• PSA: 32.67000
• LogP: 1.12
• 蒸汽压: 0.6±0.3 mmHg at 25°C
• 折射率: 1.453
• 储存条件: Refrigerator, Under Inert Atmosphere

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : IM4360000 CHEMICAL NAME : Diisopropylamine, N-nitroso- CAS REGISTRY NUMBER : 601-77-4 BEILSTEIN REFERENCE NO. : 0635986 LAST UPDATED : 199709 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C6-H14-N2-O MOLECULAR WEIGHT : 130.22 WISWESSER LINE NOTATION : 1Y1&NNO&&Y1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 850 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 14 gm/kg/110W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1800 mg/kg/50W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors MUTATION DATA TYPE OF TEST : Phage inhibition capacity TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 300 ug/well REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,349,1991 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993

安全

• 危害码 (欧洲): T+
• 风险声明 (欧洲): 22-45
• 安全声明 (欧洲): 53
• 危险品运输编码: UN 2811
• 包装等级: III
• 危险类别: 6.1(b)

合成路线

108-18-9 ~99% 601-77-4

文献：Zolfigol; Zebarjadian; Chehardoli; Keypour; Salehzadeh; Shamsipur Journal of Organic Chemistry, 2001 , vol. 66, # 10 p. 3619 - 3620

108-18-9 ~30% 125227-81-8 601-77-4

文献：Journal of the American Chemical Society, , vol. 112, # 6 p. 2383 - 2386

543-67-9 108-18-9 ~% 71-23-8 601-77-4

文献：Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 6 p. 987 - 991

4164-30-1 ~% 601-77-4

文献：Journal of Physical Chemistry, , vol. 98, # 28 p. 7004 - 7008

7782-77-6 75-31-0 ~% 187737-37-7 67-63-0 详细

文献：Ber., , vol. 9, p. 535 Liebigs Annalen der Chemie, , vol. 144, p. 140

4164-30-1 ~% 67-64-1 601-77-4

文献：Journal of Physical Chemistry, , vol. 96, # 6 p. 2505 - 2509

80-11-5 108-18-9 ~% 601-77-4 640-61-9

文献：Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 1 p. 29 - 37

34915-40-7 ~% 601-77-4

文献：Recueil des Travaux Chimiques des Pays-Bas, , vol. 8, p. 205,212

7732-18-5 34915-40-7 ~% 601-77-4

文献：Recueil des Travaux Chimiques des Pays-Bas, , vol. 8, p. 205,212

上下游产品

上游产品  8
108-18-9 543-67-9 4164-30-1 7782-77-6
75-31-0 80-11-5 34915-40-7 7732-18-5
下游产品  4
108-18-9 921-14-2 3332-08-9 52135-59-8