11006-76-1

• 常用中文名：维吉尼霉素
• 常用英文名：Virginiamycin
• CAS号：11006-76-1
• 分子式：C₇₁H₈₄N₁₀O₁₇
• 分子量：1349.484
• 相关类别： 原料药 饲料药物添加剂
• 发布时间：2018-09-15 12:06:29
• 更新时间：2026-06-30 21:30:47
• 维吉尼亚霉素复合物包含两种链霉素抗生素,维吉尼亚霉素M1和维吉尼亚霉素S1。作为一种复合物,这两种抗生素协同作用,不可逆地抑制细菌中的蛋白质合成[1]。

名称

• 中文名: 维吉尼霉素
• 英文名: Virginiamycin complex
• 中文别名: 肥大霉素; 乙腈中维吉尼亚霉素; 甲醇中维及霉素; 维及霉素溶液,100PPM; 美加霉素; 春霉素; 维吉霉素; 维及霉素; 维吉尼亚霉素/速大肥/维吉尼霉素含量; 威及霉素; 弗吉尼亚霉素; 米卡霉素; 维吉尼霉素(奥斯立星、抗金菌霉素、菌素849、美加霉素、米加霉素、米卡霉素、蜜柑霉素、普那霉素); 米加霉素; 始霉素; 抗金葡霉素; 抗菌素; 吉尼霉素; 链阳霉素; 普那霉素; 蜜柑霉素; 抗金菌霉素; 奥斯立星; 维吉尼霉素杂质; 维吉尼亚霉素; 维得霉素; 抗金葡萄素; 乙腈中维吉尼霉素; 弗吉尼亚霉素复合物; 威里霉素
• 英文别名: Lactrol; VirginiamycinnnDISCONTINUED; N-(22-Benzyl-6-ethyl-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl)-3-hydroxy-2-pyridinecarboxamide - (12Z,17Z,19Z)-21-hydroxy-10-isopropyl-11,19-dimethyl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.0]octacosa-1(27),6,12,17,19,25(28)-hexaene-2,8,14,23-tetrone (1:1); virgimycin; VirginiaMycin DISCONTINUED; virginiamycin staphylomycin; patricin; N-(22-Benzyl-6-ethyl-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl)-3-hydroxy-2-pyridinecarboxamide - 21 ;-hydroxy-10-isopropyl-11,19-dimethyl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.0]octacosa-1(27),6,12,17,19,25(28)-hexaene-2,8,14,23-tetrone (1:1); skf7988; vglnlamycinM1orS1; Virginiamycin complex (Mixture of M1 and S1); vernamycin; Virginiamycin - Activity; Stafac 20; stapyocine; mikamycin; VIRGINIAMYCIN; stafac500; VIRGINIAMICIN; Virginiamycin 1000 μg/mL in Acetonitrile; PRISTINAMYCIN //BP; eskalin500; Virginiamycin M1S1; Aids-008734; antibioticno; Virginimycin; Virginiamycin in Acetonitrile; ostreoycin; PRISTINAMYCIN; eskalinv; Livelong; Virginiamycin 100 μg/mL in Acetonitrile; 2-Pyridinecarboxamide, N-[6-ethyldocosahydro-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyl-22-(phenylmethyl)-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl]-3-hydroxy-, compd. with 8,9,14,15,24,25-hexahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone (1:1); strtoamin; pyostacine; Aids008734; Virginiamycin complex (Mixture of M1 and S1) in DMSO; Stafac; Pyostacin; V-max; Strtoamin (6CI); rp7293

物化性质

• 熔点: 170-178ºC
• 分子式: C₇₁H₈₄N₁₀O₁₇
• 分子量: 1349.484
• 精确质量: 1348.601563
• PSA: 363.76000
• LogP: 4.99230
• 外观性状: 白色固体
• 储存条件: -20℃

生物活性

• 描述: 维吉尼亚霉素复合物包含两种链霉素抗生素,维吉尼亚霉素M1和维吉尼亚霉素S1。作为一种复合物,这两种抗生素协同作用,不可逆地抑制细菌中的蛋白质合成[1]。
• 相关类别:
  研究领域 >> 感染
• 参考文献:

  [1]. Parfait R, Cocito C. Lasting damage to bacterial ribosomes by reversibly bound virginiamycin M. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5492-6.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : ZA4850000 CHEMICAL NAME : Virginiamycin CAS REGISTRY NUMBER : 11006-76-1 LAST UPDATED : 199707 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,383,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 1,171,1953/1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,383,1978